ADPRH — 50 ClinVar variants
All ClinVar germline ADPRH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
3 Likely benign · 47 Uncertain significance
Full ADPRH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADPRH p.Ala293Thr Uncertain significance Single submitter
- ADPRH p.Ala64Val Uncertain significance Single submitter
- ADPRH p.Asn116Ser Uncertain significance Single submitter
- ADPRH p.Asp255His Uncertain significance Single submitter
- ADPRH p.Gly139Arg Uncertain significance Single submitter
- ADPRH p.Gly18Glu Uncertain significance Single submitter
- ADPRH p.His294Arg Uncertain significance Single submitter
- ADPRH p.His299Arg Uncertain significance Single submitter
- ADPRH p.His299Leu Uncertain significance Single submitter
- ADPRH p.Ile138Val Uncertain significance Single submitter
- ADPRH p.Ile236Val Uncertain significance Single submitter
- ADPRH p.Leu337Arg Uncertain significance Single submitter
- ADPRH p.Lys85Glu Uncertain significance Single submitter
- ADPRH p.Met133Ile Uncertain significance Single submitter
- ADPRH p.Met8Leu Uncertain significance Single submitter
- ADPRH p.Ser264Pro Uncertain significance Single submitter
- ADPRH p.Trp191Ser Uncertain significance Single submitter
- ADPRH p.Tyr81Cys Uncertain significance Single submitter
- ADPRH p.Val323Leu Uncertain significance Single submitter
- ADPRH p.Val9Met Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- ADPRH p.Ala13Gly Uncertain significance Single submitter
- ADPRH p.Ala174Val Likely benign Single submitter
- ADPRH p.Ala182Thr Uncertain significance Single submitter
- ADPRH p.Ala296Thr Uncertain significance Single submitter
- ADPRH p.Ala310Ser Uncertain significance Single submitter
- ADPRH p.Ala341Thr Uncertain significance Single submitter
- ADPRH p.Ala70Gly Uncertain significance Single submitter
- ADPRH p.Arg160Gln Uncertain significance Single submitter
- ADPRH p.Arg234Lys Uncertain significance Single submitter
- ADPRH p.Gln109His Uncertain significance Single submitter
- ADPRH p.Glu291Asp Uncertain significance Single submitter
- ADPRH p.Gly239Arg Uncertain significance Single submitter
- ADPRH p.Gly42Ser Uncertain significance Single submitter
- ADPRH p.His164Asp Uncertain significance Single submitter
- ADPRH p.Ile156Thr Uncertain significance Single submitter
- ADPRH p.Ile277Met Uncertain significance Single submitter
- ADPRH p.Ile33Val Uncertain significance Single submitter
- ADPRH p.Leu140Phe Uncertain significance Single submitter
- ADPRH p.Leu283Ile Uncertain significance Single submitter
- ADPRH p.Met8Ile Uncertain significance Single submitter
- ADPRH p.Phe223Tyr Uncertain significance Single submitter
- ADPRH p.Pro112Leu Uncertain significance Single submitter
- ADPRH p.Ser103Leu Uncertain significance Single submitter
- ADPRH p.Thr167Ala Uncertain significance Single submitter
- ADPRH p.Trp220Cys Uncertain significance Single submitter
- ADPRH p.Tyr181Ser Uncertain significance Single submitter
- ADPRH p.Tyr80Cys Uncertain significance Single submitter
- ADPRH p.Val183Met Uncertain significance Single submitter
All ADPRH variants
Likely benign 3
- p.Ala174Val Single submitter ⚠
- p.Arg35Gln Single submitter
- p.Val282Ile Single submitter
Uncertain significance 47
- p.Ala13Gly Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala293Thr Single submitter ⚠
- p.Ala296Thr Single submitter ⚠
- p.Ala310Ser Single submitter ⚠
- p.Ala341Thr Single submitter ⚠
- p.Ala64Val Single submitter ⚠
- p.Ala70Gly Single submitter ⚠
- p.Arg160Gln Single submitter ⚠
- p.Arg234Lys Single submitter ⚠
- p.Asn116Ser Single submitter ⚠
- p.Asp255His Single submitter ⚠
- p.Gln109His Single submitter ⚠
- p.Glu291Asp Single submitter ⚠
- p.Gly139Arg Single submitter ⚠
- p.Gly18Glu Single submitter ⚠
- p.Gly239Arg Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.His164Asp Single submitter ⚠
- p.His294Arg Single submitter ⚠
- p.His299Arg Single submitter ⚠
- p.His299Leu Single submitter ⚠
- p.Ile138Val Single submitter ⚠
- p.Ile156Thr Single submitter ⚠
- p.Ile236Val Single submitter ⚠
- p.Ile277Met Single submitter ⚠
- p.Ile33Val Single submitter ⚠
- p.Leu140Phe Single submitter ⚠
- p.Leu283Ile Single submitter ⚠
- p.Leu337Arg Single submitter ⚠
- p.Lys85Glu Single submitter ⚠
- p.Met133Ile Single submitter ⚠
- p.Met8Ile Single submitter ⚠
- p.Met8Leu Single submitter ⚠
- p.Phe223Tyr Single submitter ⚠
- p.Pro112Leu Single submitter ⚠
- p.Ser103Leu Single submitter ⚠
- p.Ser264Pro Single submitter ⚠
- p.Thr167Ala Single submitter ⚠
- p.Trp191Ser Single submitter ⚠
- p.Trp220Cys Single submitter ⚠
- p.Tyr181Ser Single submitter ⚠
- p.Tyr80Cys Single submitter ⚠
- p.Tyr81Cys Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val323Leu Single submitter ⚠
- p.Val9Met Single submitter ⚠