ADPRM — 33 ClinVar variants
All ClinVar germline ADPRM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
4 Likely benign · 29 Uncertain significance
Full ADPRM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADPRM p.Ala24Val Uncertain significance Single submitter
- ADPRM p.Arg16Cys Uncertain significance Single submitter
- ADPRM p.Arg324Lys Uncertain significance Single submitter
- ADPRM p.Asn80Lys Uncertain significance Single submitter
- ADPRM p.Asp74Glu Uncertain significance Single submitter
- ADPRM p.Asp77Asn Uncertain significance Single submitter
- ADPRM p.Asp95Glu Uncertain significance Single submitter
- ADPRM p.Glu119Lys Uncertain significance Single submitter
- ADPRM p.Glu286Lys Uncertain significance Single submitter
- ADPRM p.Gly325Asp Uncertain significance Single submitter
- ADPRM p.Gly73Arg Uncertain significance Single submitter
- ADPRM p.His268Asp Uncertain significance Single submitter
- ADPRM p.His341Arg Uncertain significance Single submitter
- ADPRM p.Leu121Phe Uncertain significance Single submitter
- ADPRM p.Leu163Phe Uncertain significance Single submitter
- ADPRM p.Met332Thr Uncertain significance Single submitter
- ADPRM p.Phe275Ile Uncertain significance Single submitter
- ADPRM p.Pro192Ala Uncertain significance Single submitter
- ADPRM p.Pro5Ser Uncertain significance Single submitter
- ADPRM p.Pro5Thr Uncertain significance Single submitter
- ADPRM p.Ser249Cys Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ADPRM p.Ala248Thr Uncertain significance Single submitter
- ADPRM p.Arg42Trp Uncertain significance Single submitter
- ADPRM p.His51Gln Uncertain significance Single submitter
- ADPRM p.Ile56Thr Uncertain significance Single submitter
- ADPRM p.Ile75Val Uncertain significance Single submitter
- ADPRM p.Phe35Leu Uncertain significance Single submitter
- ADPRM p.Pro246Leu Uncertain significance Single submitter
- ADPRM p.Ser86Pro Uncertain significance Single submitter
All ADPRM variants
Likely benign 4
- c.-18+52T>G Multiple submitters
- p.Asn295Ser Single submitter
- p.Asp247= Single submitter
- p.Val173Met Single submitter
Uncertain significance 29
- p.Ala248Thr Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Arg16Cys Single submitter ⚠
- p.Arg324Lys Single submitter ⚠
- p.Arg42Trp Single submitter ⚠
- p.Asn80Lys Single submitter ⚠
- p.Asp74Glu Single submitter ⚠
- p.Asp77Asn Single submitter ⚠
- p.Asp95Glu Single submitter ⚠
- p.Glu119Lys Single submitter ⚠
- p.Glu286Lys Single submitter ⚠
- p.Gly325Asp Single submitter ⚠
- p.Gly73Arg Single submitter ⚠
- p.His268Asp Single submitter ⚠
- p.His341Arg Single submitter ⚠
- p.His51Gln Single submitter ⚠
- p.Ile56Thr Single submitter ⚠
- p.Ile75Val Single submitter ⚠
- p.Leu121Phe Single submitter ⚠
- p.Leu163Phe Single submitter ⚠
- p.Met332Thr Single submitter ⚠
- p.Phe275Ile Single submitter ⚠
- p.Phe35Leu Single submitter ⚠
- p.Pro192Ala Single submitter ⚠
- p.Pro246Leu Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Pro5Thr Single submitter ⚠
- p.Ser249Cys Single submitter ⚠
- p.Ser86Pro Single submitter ⚠