ADRA1A — 72 ClinVar variants
All ClinVar germline ADRA1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
5 Benign · 1 Likely benign · 66 Uncertain significance
Full ADRA1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADRA1A p.Ala112Glu Uncertain significance Single submitter
- ADRA1A p.Ala189Glu Uncertain significance Single submitter
- ADRA1A p.Ala355Asp Uncertain significance Single submitter
- ADRA1A p.Ala52Val Uncertain significance Single submitter
- ADRA1A p.Ala71Asp Uncertain significance Single submitter
- ADRA1A p.Ala8Ser Uncertain significance Single submitter
- ADRA1A p.Arg124Cys Uncertain significance Single submitter
- ADRA1A p.Arg166Gly Uncertain significance Single submitter
- ADRA1A p.Arg387Ser Uncertain significance Single submitter
- ADRA1A p.Arg423Gln Uncertain significance Single submitter
- ADRA1A p.Asn13Ser Uncertain significance Single submitter
- ADRA1A p.Asn13Thr Uncertain significance Single submitter
- ADRA1A p.Asn179Ser Uncertain significance Single submitter
- ADRA1A p.Asn240Ser Uncertain significance Single submitter
- ADRA1A p.Asn67Ser Uncertain significance Single submitter
- ADRA1A p.Asp225His Uncertain significance Single submitter
- ADRA1A p.Cys14Gly Uncertain significance Single submitter
- ADRA1A p.Cys347Tyr Uncertain significance Single submitter
- ADRA1A p.Glu305Asp Uncertain significance Single submitter
- ADRA1A p.Gly221Ser Uncertain significance Single submitter
- ADRA1A p.Ile126Leu Uncertain significance Single submitter
- ADRA1A p.Ile159Val Uncertain significance Single submitter
- ADRA1A p.Ile48Val Uncertain significance Single submitter
- ADRA1A p.Ile65Val Uncertain significance Single submitter
- ADRA1A p.Leu195Pro Uncertain significance Single submitter
- ADRA1A p.Leu430Ser Uncertain significance Single submitter
- ADRA1A p.Leu74Arg Uncertain significance Single submitter
- ADRA1A p.Lys309Arg Uncertain significance Single submitter
- ADRA1A p.Lys335Thr Uncertain significance Single submitter
- ADRA1A p.Lys349Glu Uncertain significance Single submitter
- ADRA1A p.Met145Ile Uncertain significance Single submitter
- ADRA1A p.Met248Thr Uncertain significance Single submitter
- ADRA1A p.Met403Thr Uncertain significance Single submitter
- ADRA1A p.Phe333Val Uncertain significance Single submitter
- ADRA1A p.Pro135Leu Uncertain significance Single submitter
- ADRA1A p.Pro363Arg Uncertain significance Single submitter
- ADRA1A p.Pro441Ala Uncertain significance Single submitter
- ADRA1A p.Ser154Phe Uncertain significance Single submitter
- ADRA1A p.Ser192Pro Uncertain significance Single submitter
- ADRA1A p.Ser246Asn Uncertain significance Single submitter
- ADRA1A p.Ser439Pro Uncertain significance Single submitter
- ADRA1A p.Ser59Pro Uncertain significance Single submitter
- ADRA1A p.Ser5Leu Uncertain significance Single submitter
- ADRA1A p.Thr440Ala Uncertain significance Single submitter
- ADRA1A p.Trp151Ser Uncertain significance Single submitter
- ADRA1A p.Trp313Cys Uncertain significance Single submitter
- ADRA1A p.Tyr194Cys Uncertain significance Single submitter
- ADRA1A p.Val107Met Uncertain significance Single submitter
- ADRA1A p.Val150Ile Uncertain significance Single submitter
- ADRA1A p.Val379Met Uncertain significance Single submitter
- ADRA1A p.Val412Ala Uncertain significance Single submitter
- ADRA1A p.Val432Phe Uncertain significance Single submitter
- ADRA1A p.Val97Phe Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ADRA1A p.Arg216Gly Uncertain significance Single submitter
- ADRA1A p.Gln344Pro Uncertain significance Single submitter
- ADRA1A p.Gly463Arg Uncertain significance Single submitter
- ADRA1A p.His58Pro Uncertain significance Single submitter
- ADRA1A p.Ile126Met Uncertain significance Single submitter
- ADRA1A p.Leu290Ser Uncertain significance Single submitter
- ADRA1A p.Lys335Asn Uncertain significance Single submitter
- ADRA1A p.Phe94Leu Uncertain significance Single submitter
- ADRA1A p.Pro168Arg Uncertain significance Single submitter
- ADRA1A p.Pro293Ser Uncertain significance Single submitter
- ADRA1A p.Thr76Ile Uncertain significance Single submitter
- ADRA1A p.Val138Leu Uncertain significance Single submitter
All ADRA1A variants
Benign 5
- p.Ala241= Multiple submitters
- p.Ser154= Multiple submitters
- p.Ser154Ala Multiple submitters
- p.Thr273= Multiple submitters
- p.Ser401= Single submitter
Likely benign 1
- p.Thr253Asn Single submitter
Uncertain significance 66
- p.Ala112Glu Single submitter ⚠
- p.Ala189Glu Single submitter ⚠
- p.Ala355Asp Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala71Asp Single submitter ⚠
- p.Ala8Ser Single submitter ⚠
- p.Arg124Cys Single submitter ⚠
- p.Arg166Gly Single submitter ⚠
- p.Arg216Gly Single submitter ⚠
- p.Arg238Trp Single submitter
- p.Arg387Ser Single submitter ⚠
- p.Arg423Gln Single submitter ⚠
- p.Asn13Ser Single submitter ⚠
- p.Asn13Thr Single submitter ⚠
- p.Asn179Ser Single submitter ⚠
- p.Asn240Ser Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Asp225His Single submitter ⚠
- p.Cys14Gly Single submitter ⚠
- p.Cys347Tyr Single submitter ⚠
- p.Gln344Pro Single submitter ⚠
- p.Glu305Asp Single submitter ⚠
- p.Gly221Ser Single submitter ⚠
- p.Gly463Arg Single submitter ⚠
- p.His58Pro Single submitter ⚠
- p.Ile126Leu Single submitter ⚠
- p.Ile126Met Single submitter ⚠
- p.Ile159Val Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Ile65Val Single submitter ⚠
- p.Leu195Pro Single submitter ⚠
- p.Leu290Ser Single submitter ⚠
- p.Leu430Ser Single submitter ⚠
- p.Leu74Arg Single submitter ⚠
- p.Lys309Arg Single submitter ⚠
- p.Lys335Asn Single submitter ⚠
- p.Lys335Thr Single submitter ⚠
- p.Lys349Glu Single submitter ⚠
- p.Met145Ile Single submitter ⚠
- p.Met248Thr Single submitter ⚠
- p.Met403Thr Single submitter ⚠
- p.Phe333Val Single submitter ⚠
- p.Phe94Leu Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro168Arg Single submitter ⚠
- p.Pro293Ser Single submitter ⚠
- p.Pro363Arg Single submitter ⚠
- p.Pro441Ala Single submitter ⚠
- p.Ser154Phe Single submitter ⚠
- p.Ser192Pro Single submitter ⚠
- p.Ser246Asn Single submitter ⚠
- p.Ser439Pro Single submitter ⚠
- p.Ser59Pro Single submitter ⚠
- p.Ser5Leu Single submitter ⚠
- p.Thr440Ala Single submitter ⚠
- p.Thr76Ile Single submitter ⚠
- p.Trp151Ser Single submitter ⚠
- p.Trp313Cys Single submitter ⚠
- p.Tyr194Cys Single submitter ⚠
- p.Val107Met Single submitter ⚠
- p.Val138Leu Single submitter ⚠
- p.Val150Ile Single submitter ⚠
- p.Val379Met Single submitter ⚠
- p.Val412Ala Single submitter ⚠
- p.Val432Phe Single submitter ⚠
- p.Val97Phe Single submitter ⚠