ADRA1B — 93 ClinVar variants
All ClinVar germline ADRA1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
1 Benign · 3 Likely benign · 89 Uncertain significance
Full ADRA1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADRA1B p.Ala188Thr Uncertain significance Single submitter
- ADRA1B p.Ala217Val Uncertain significance Single submitter
- ADRA1B p.Ala449Thr Uncertain significance Single submitter
- ADRA1B p.Ala503Thr Uncertain significance Single submitter
- ADRA1B p.Ala516Glu Uncertain significance Single submitter
- ADRA1B p.Ala90Asp Uncertain significance Single submitter
- ADRA1B p.Arg115Gln Uncertain significance Single submitter
- ADRA1B p.Arg159Gly Uncertain significance Single submitter
- ADRA1B p.Arg370Gly Uncertain significance Single submitter
- ADRA1B p.Arg403Leu Uncertain significance Single submitter
- ADRA1B p.Arg433Gly Uncertain significance Single submitter
- ADRA1B p.Arg465Leu Uncertain significance Single submitter
- ADRA1B p.Asn247Thr Uncertain significance Single submitter
- ADRA1B p.Asn24Thr Uncertain significance Single submitter
- ADRA1B p.Asn504Ser Uncertain significance Single submitter
- ADRA1B p.Asn512Ser Uncertain significance Single submitter
- ADRA1B p.Cys137Trp Uncertain significance Single submitter
- ADRA1B p.Cys413Arg Uncertain significance Single submitter
- ADRA1B p.Gln366Arg Uncertain significance Single submitter
- ADRA1B p.Glu186Gly Uncertain significance Single submitter
- ADRA1B p.Glu19Gln Uncertain significance Single submitter
- ADRA1B p.Glu446Ala Uncertain significance Single submitter
- ADRA1B p.Glu481Val Uncertain significance Single submitter
- ADRA1B p.Glu483Lys Uncertain significance Single submitter
- ADRA1B p.Gly364Arg Uncertain significance Single submitter
- ADRA1B p.Gly383Asp Uncertain significance Single submitter
- ADRA1B p.Gly451Ser Uncertain significance Single submitter
- ADRA1B p.Gly471Cys Uncertain significance Single submitter
- ADRA1B p.Gly8Ser Uncertain significance Single submitter
- ADRA1B p.His261Gln Uncertain significance Single submitter
- ADRA1B p.His9Tyr Uncertain significance Single submitter
- ADRA1B p.Ile60Val Uncertain significance Single submitter
- ADRA1B p.Leu182Ile Uncertain significance Single submitter
- ADRA1B p.Leu381Arg Uncertain significance Single submitter
- ADRA1B p.Leu381Pro Uncertain significance Single submitter
- ADRA1B p.Leu478Val Uncertain significance Single submitter
- ADRA1B p.Lys404Arg Uncertain significance Single submitter
- ADRA1B p.Lys477Glu Uncertain significance Single submitter
- ADRA1B p.Met513Thr Uncertain significance Single submitter
- ADRA1B p.Met513Val Uncertain significance Single submitter
- ADRA1B p.Pro275Arg Uncertain significance Single submitter
- ADRA1B p.Pro28Leu Uncertain significance Single submitter
- ADRA1B p.Pro345Leu Uncertain significance Single submitter
- ADRA1B p.Pro390Ser Uncertain significance Single submitter
- ADRA1B p.Pro426Leu Uncertain significance Single submitter
- ADRA1B p.Pro438Gln Uncertain significance Single submitter
- ADRA1B p.Pro462Arg Uncertain significance Single submitter
- ADRA1B p.Pro472Thr Uncertain significance Single submitter
- ADRA1B p.Ser207Tyr Uncertain significance Single submitter
- ADRA1B p.Ser415Thr Uncertain significance Single submitter
- ADRA1B p.Ser425Leu Uncertain significance Single submitter
- ADRA1B p.Ser95Gly Uncertain significance Single submitter
- ADRA1B p.Thr7Ala Uncertain significance Single submitter
- ADRA1B p.Trp184Cys Uncertain significance Single submitter
- ADRA1B p.Trp391Arg Uncertain significance Single submitter
- ADRA1B p.Trp447Gly Uncertain significance Single submitter
- ADRA1B p.Tyr388Cys Uncertain significance Single submitter
- ADRA1B p.Tyr82Phe Uncertain significance Single submitter
- ADRA1B p.Val171Ile Uncertain significance Single submitter
- ADRA1B p.Val360Met Uncertain significance Single submitter
- ADRA1B p.Val439Phe Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- ADRA1B p.Ala54Pro Uncertain significance Single submitter
- ADRA1B p.Arg225His Uncertain significance Single submitter
- ADRA1B p.Arg357Ser Uncertain significance Single submitter
- ADRA1B p.Arg378Cys Uncertain significance Single submitter
- ADRA1B p.Arg379Cys Uncertain significance Single submitter
- ADRA1B p.Arg467His Uncertain significance Single submitter
- ADRA1B p.Asn24Ile Uncertain significance Single submitter
- ADRA1B p.Asp327Asn Uncertain significance Single submitter
- ADRA1B p.Gly369Asp Uncertain significance Single submitter
- ADRA1B p.Gly382Val Uncertain significance Single submitter
- ADRA1B p.Gly463Val Uncertain significance Single submitter
- ADRA1B p.Ile141Phe Uncertain significance Single submitter
- ADRA1B p.Ile141Thr Uncertain significance Single submitter
- ADRA1B p.Ile279Thr Uncertain significance Single submitter
- ADRA1B p.Ile312Phe Uncertain significance Single submitter
- ADRA1B p.Ile46Thr Uncertain significance Single submitter
- ADRA1B p.Leu167Phe Uncertain significance Single submitter
- ADRA1B p.Leu478Phe Uncertain significance Single submitter
- ADRA1B p.Lys269Asn Uncertain significance Single submitter
- ADRA1B p.Pro187Leu Uncertain significance Single submitter
- ADRA1B p.Pro325Thr Uncertain significance Single submitter
- ADRA1B p.Pro445His Uncertain significance Single submitter
- ADRA1B p.Pro462Leu Uncertain significance Single submitter
- ADRA1B p.Ser277Arg Uncertain significance Single submitter
- ADRA1B p.Ser402Trp Uncertain significance Single submitter
- ADRA1B p.Ser470Leu Uncertain significance Single submitter
- ADRA1B p.Thr155Lys Uncertain significance Single submitter
- ADRA1B p.Thr480Ile Uncertain significance Single submitter
All ADRA1B variants
Benign 1
- p.Cys367= Single submitter
Uncertain significance 89
- p.Ala188Thr Single submitter ⚠
- p.Ala217Val Single submitter ⚠
- p.Ala449Thr Single submitter ⚠
- p.Ala503Thr Single submitter ⚠
- p.Ala516Glu Single submitter ⚠
- p.Ala54Pro Single submitter ⚠
- p.Ala90Asp Single submitter ⚠
- p.Arg115Gln Single submitter ⚠
- p.Arg159Gly Single submitter ⚠
- p.Arg225His Single submitter ⚠
- p.Arg357Ser Single submitter ⚠
- p.Arg370Gly Single submitter ⚠
- p.Arg378Cys Single submitter ⚠
- p.Arg379Cys Single submitter ⚠
- p.Arg403Leu Single submitter ⚠
- p.Arg433Gly Single submitter ⚠
- p.Arg465Leu Single submitter ⚠
- p.Arg467His Single submitter ⚠
- p.Asn247Thr Single submitter ⚠
- p.Asn24Ile Single submitter ⚠
- p.Asn24Thr Single submitter ⚠
- p.Asn504Ser Single submitter ⚠
- p.Asn512Ser Single submitter ⚠
- p.Asp327Asn Single submitter ⚠
- p.Cys137Trp Single submitter ⚠
- p.Cys413Arg Single submitter ⚠
- p.Gln366Arg Single submitter ⚠
- p.Glu186Gly Single submitter ⚠
- p.Glu19Gln Single submitter ⚠
- p.Glu446Ala Single submitter ⚠
- p.Glu481Val Single submitter ⚠
- p.Glu483Lys Single submitter ⚠
- p.Gly364Arg Single submitter ⚠
- p.Gly369Asp Single submitter ⚠
- p.Gly382Val Single submitter ⚠
- p.Gly383Asp Single submitter ⚠
- p.Gly451Ser Single submitter ⚠
- p.Gly463Val Single submitter ⚠
- p.Gly471Cys Single submitter ⚠
- p.Gly8Ser Single submitter ⚠
- p.His261Gln Single submitter ⚠
- p.His9Tyr Single submitter ⚠
- p.Ile141Phe Single submitter ⚠
- p.Ile141Thr Single submitter ⚠
- p.Ile279Thr Single submitter ⚠
- p.Ile312Phe Single submitter ⚠
- p.Ile46Thr Single submitter ⚠
- p.Ile60Val Single submitter ⚠
- p.Leu167Phe Single submitter ⚠
- p.Leu182Ile Single submitter ⚠
- p.Leu381Arg Single submitter ⚠
- p.Leu381Pro Single submitter ⚠
- p.Leu478Phe Single submitter ⚠
- p.Leu478Val Single submitter ⚠
- p.Lys269Asn Single submitter ⚠
- p.Lys404Arg Single submitter ⚠
- p.Lys477Glu Single submitter ⚠
- p.Met513Thr Single submitter ⚠
- p.Met513Val Single submitter ⚠
- p.Pro187Leu Single submitter ⚠
- p.Pro275Arg Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro325Thr Single submitter ⚠
- p.Pro345Leu Single submitter ⚠
- p.Pro390Ser Single submitter ⚠
- p.Pro426Leu Single submitter ⚠
- p.Pro438Gln Single submitter ⚠
- p.Pro445His Single submitter ⚠
- p.Pro462Arg Single submitter ⚠
- p.Pro462Leu Single submitter ⚠
- p.Pro472Thr Single submitter ⚠
- p.Ser207Tyr Single submitter ⚠
- p.Ser277Arg Single submitter ⚠
- p.Ser402Trp Single submitter ⚠
- p.Ser415Thr Single submitter ⚠
- p.Ser425Leu Single submitter ⚠
- p.Ser470Leu Single submitter ⚠
- p.Ser95Gly Single submitter ⚠
- p.Thr155Lys Single submitter ⚠
- p.Thr480Ile Single submitter ⚠
- p.Thr7Ala Single submitter ⚠
- p.Trp184Cys Single submitter ⚠
- p.Trp391Arg Single submitter ⚠
- p.Trp447Gly Single submitter ⚠
- p.Tyr388Cys Single submitter ⚠
- p.Tyr82Phe Single submitter ⚠
- p.Val171Ile Single submitter ⚠
- p.Val360Met Single submitter ⚠
- p.Val439Phe Single submitter ⚠