ADRA1D — 116 ClinVar variants
All ClinVar germline ADRA1D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 111 flagged for review →
1 Benign · 4 Likely benign · 111 Uncertain significance
Full ADRA1D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 111
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADRA1D p.Ala174Val Uncertain significance Single submitter
- ADRA1D p.Ala20Gly Uncertain significance Single submitter
- ADRA1D p.Ala218Val Uncertain significance Single submitter
- ADRA1D p.Ala255Pro Uncertain significance Single submitter
- ADRA1D p.Ala35Gly Uncertain significance Single submitter
- ADRA1D p.Ala36Gly Uncertain significance Single submitter
- ADRA1D p.Ala42Pro Uncertain significance Single submitter
- ADRA1D p.Ala42Val Uncertain significance Single submitter
- ADRA1D p.Ala531Val Uncertain significance Single submitter
- ADRA1D p.Ala554Gly Uncertain significance Single submitter
- ADRA1D p.Ala562Gly Uncertain significance Single submitter
- ADRA1D p.Ala75Gly Uncertain significance Single submitter
- ADRA1D p.Arg166Cys Uncertain significance Single submitter
- ADRA1D p.Arg166Ser Uncertain significance Single submitter
- ADRA1D p.Arg211Gly Uncertain significance Single submitter
- ADRA1D p.Arg282Gly Uncertain significance Single submitter
- ADRA1D p.Arg342His Uncertain significance Single submitter
- ADRA1D p.Arg439Pro Uncertain significance Single submitter
- ADRA1D p.Arg446His Uncertain significance Single submitter
- ADRA1D p.Asp193Glu Uncertain significance Single submitter
- ADRA1D p.Asp242His Uncertain significance Single submitter
- ADRA1D p.Asp563Asn Uncertain significance Single submitter
- ADRA1D p.Glu210Gln Uncertain significance Single submitter
- ADRA1D p.Glu295Val Uncertain significance Single submitter
- ADRA1D p.Gly165Arg Uncertain significance Single submitter
- ADRA1D p.Gly22Ser Uncertain significance Single submitter
- ADRA1D p.Gly230Arg Uncertain significance Single submitter
- ADRA1D p.Gly247Ser Uncertain significance Single submitter
- ADRA1D p.Gly317Arg Uncertain significance Single submitter
- ADRA1D p.Gly320Asp Uncertain significance Single submitter
- ADRA1D p.Gly355Arg Uncertain significance Single submitter
- ADRA1D p.Gly391Ser Uncertain significance Single submitter
- ADRA1D p.Gly435Val Uncertain significance Single submitter
- ADRA1D p.Gly476Val Uncertain significance Single submitter
- ADRA1D p.His319Gln Uncertain significance Single submitter
- ADRA1D p.His437Asn Uncertain significance Single submitter
- ADRA1D p.Ile190Leu Uncertain significance Single submitter
- ADRA1D p.Ile190Phe Uncertain significance Single submitter
- ADRA1D p.Ile248Phe Uncertain significance Single submitter
- ADRA1D p.Ile352Val Uncertain significance Single submitter
- ADRA1D p.Ile401Val Uncertain significance Single submitter
- ADRA1D p.Leu108Phe Uncertain significance Single submitter
- ADRA1D p.Leu416Arg Uncertain significance Single submitter
- ADRA1D p.Lys339Gln Uncertain significance Single submitter
- ADRA1D p.Lys344Asn Uncertain significance Single submitter
- ADRA1D p.Met273Thr Uncertain significance Single submitter
- ADRA1D p.Pro457Arg Uncertain significance Single submitter
- ADRA1D p.Pro457Leu Uncertain significance Single submitter
- ADRA1D p.Pro502Ala Uncertain significance Single submitter
- ADRA1D p.Pro502Leu Uncertain significance Single submitter
- ADRA1D p.Ser153Leu Uncertain significance Single submitter
- ADRA1D p.Ser492Arg Uncertain significance Single submitter
- ADRA1D p.Ser74Arg Uncertain significance Single submitter
- ADRA1D p.Ser8Arg Uncertain significance Single submitter
- ADRA1D p.Thr189Ser Uncertain significance Single submitter
- ADRA1D p.Thr313Lys Uncertain significance Single submitter
- ADRA1D p.Thr477Ala Uncertain significance Single submitter
- ADRA1D p.Thr477Arg Uncertain significance Single submitter
- ADRA1D p.Thr508Ser Uncertain significance Single submitter
- ADRA1D p.Val227Leu Uncertain significance Single submitter
- ADRA1D p.Val397Met Uncertain significance Single submitter
- ADRA1D p.Val514Ala Uncertain significance Single submitter
- ADRA1D p.Val81Leu Uncertain significance Single submitter
Predictors split 48
The independent predictors disagree with each other — read with care.
- ADRA1D p.Ala20Thr Uncertain significance Single submitter
- ADRA1D p.Ala534Thr Uncertain significance Single submitter
- ADRA1D p.Arg244Pro Uncertain significance Single submitter
- ADRA1D p.Arg309Pro Uncertain significance Single submitter
- ADRA1D p.Arg330His Uncertain significance Single submitter
- ADRA1D p.Arg336His Uncertain significance Single submitter
- ADRA1D p.Arg407Ser Uncertain significance Single submitter
- ADRA1D p.Arg411Gly Uncertain significance Single submitter
- ADRA1D p.Arg422Cys Uncertain significance Single submitter
- ADRA1D p.Arg426Cys Uncertain significance Single submitter
- ADRA1D p.Arg428Leu Uncertain significance Single submitter
- ADRA1D p.Arg495Cys Uncertain significance Single submitter
- ADRA1D p.Arg504Gln Uncertain significance Single submitter
- ADRA1D p.Asn124His Uncertain significance Single submitter
- ADRA1D p.Cys275Phe Uncertain significance Single submitter
- ADRA1D p.Glu569Asp Uncertain significance Single submitter
- ADRA1D p.Gly22Asp Uncertain significance Single submitter
- ADRA1D p.Gly253Asp Uncertain significance Single submitter
- ADRA1D p.Gly30Val Uncertain significance Single submitter
- ADRA1D p.Gly310Ser Uncertain significance Single submitter
- ADRA1D p.Gly314Val Uncertain significance Single submitter
- ADRA1D p.Gly317Glu Uncertain significance Single submitter
- ADRA1D p.Gly317Trp Uncertain significance Single submitter
- ADRA1D p.Gly48Glu Uncertain significance Single submitter
- ADRA1D p.Gly49Asp Uncertain significance Single submitter
- ADRA1D p.Gly53Ser Uncertain significance Single submitter
- ADRA1D p.Gly58Asp Uncertain significance Single submitter
- ADRA1D p.Gly73Arg Uncertain significance Single submitter
- ADRA1D p.Leu225Pro Uncertain significance Single submitter
- ADRA1D p.Leu333Phe Uncertain significance Single submitter
- ADRA1D p.Leu359Phe Uncertain significance Single submitter
- ADRA1D p.Leu7Gln Uncertain significance Single submitter
- ADRA1D p.Lys513Glu Uncertain significance Single submitter
- ADRA1D p.Met267Val Uncertain significance Single submitter
- ADRA1D p.Phe245Leu Uncertain significance Single submitter
- ADRA1D p.Pro241Leu Uncertain significance Single submitter
- ADRA1D p.Pro241Thr Uncertain significance Single submitter
- ADRA1D p.Pro478Arg Uncertain significance Single submitter
- ADRA1D p.Pro478Thr Uncertain significance Single submitter
- ADRA1D p.Ser18Arg Uncertain significance Single submitter
- ADRA1D p.Ser19Arg Uncertain significance Single submitter
- ADRA1D p.Ser331Asn Uncertain significance Single submitter
- ADRA1D p.Ser67Arg Uncertain significance Single submitter
- ADRA1D p.Val111Met Uncertain significance Single submitter
- ADRA1D p.Val175Met Uncertain significance Single submitter
- ADRA1D p.Val260Met Uncertain significance Single submitter
- ADRA1D p.Val292Ile Uncertain significance Single submitter
- ADRA1D p.Val358Leu Uncertain significance Single submitter
All ADRA1D variants
Benign 1
- p.Ser228= Single submitter
Likely benign 4
- p.Ala312Ser Single submitter
- p.Asp80Glu Single submitter
- p.Gly49Ala Single submitter
- p.Phe503Leu Single submitter
Uncertain significance 111
- p.Ala174Val Single submitter ⚠
- p.Ala20Gly Single submitter ⚠
- p.Ala20Thr Single submitter ⚠
- p.Ala218Val Single submitter ⚠
- p.Ala255Pro Single submitter ⚠
- p.Ala35Gly Single submitter ⚠
- p.Ala36Gly Single submitter ⚠
- p.Ala42Pro Single submitter ⚠
- p.Ala42Val Single submitter ⚠
- p.Ala531Val Single submitter ⚠
- p.Ala534Thr Single submitter ⚠
- p.Ala554Gly Single submitter ⚠
- p.Ala562Gly Single submitter ⚠
- p.Ala75Gly Single submitter ⚠
- p.Arg166Cys Single submitter ⚠
- p.Arg166Ser Single submitter ⚠
- p.Arg211Gly Single submitter ⚠
- p.Arg244Pro Single submitter ⚠
- p.Arg282Gly Single submitter ⚠
- p.Arg309Pro Single submitter ⚠
- p.Arg330His Single submitter ⚠
- p.Arg336His Single submitter ⚠
- p.Arg342His Single submitter ⚠
- p.Arg407Ser Single submitter ⚠
- p.Arg411Gly Single submitter ⚠
- p.Arg422Cys Single submitter ⚠
- p.Arg426Cys Single submitter ⚠
- p.Arg428Leu Single submitter ⚠
- p.Arg439Pro Single submitter ⚠
- p.Arg446His Single submitter ⚠
- p.Arg495Cys Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Asn124His Single submitter ⚠
- p.Asp193Glu Single submitter ⚠
- p.Asp242His Single submitter ⚠
- p.Asp563Asn Single submitter ⚠
- p.Cys275Phe Single submitter ⚠
- p.Glu210Gln Single submitter ⚠
- p.Glu295Val Single submitter ⚠
- p.Glu569Asp Single submitter ⚠
- p.Gly165Arg Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Gly22Ser Single submitter ⚠
- p.Gly230Arg Single submitter ⚠
- p.Gly247Ser Single submitter ⚠
- p.Gly253Asp Single submitter ⚠
- p.Gly30Val Single submitter ⚠
- p.Gly310Ser Single submitter ⚠
- p.Gly314Val Single submitter ⚠
- p.Gly317Arg Single submitter ⚠
- p.Gly317Glu Single submitter ⚠
- p.Gly317Trp Single submitter ⚠
- p.Gly320Asp Single submitter ⚠
- p.Gly355Arg Single submitter ⚠
- p.Gly391Ser Single submitter ⚠
- p.Gly435Val Single submitter ⚠
- p.Gly476Val Single submitter ⚠
- p.Gly48Glu Single submitter ⚠
- p.Gly49Asp Single submitter ⚠
- p.Gly53Ser Single submitter ⚠
- p.Gly58Asp Single submitter ⚠
- p.Gly73Arg Single submitter ⚠
- p.His319Gln Single submitter ⚠
- p.His437Asn Single submitter ⚠
- p.Ile190Leu Single submitter ⚠
- p.Ile190Phe Single submitter ⚠
- p.Ile248Phe Single submitter ⚠
- p.Ile352Val Single submitter ⚠
- p.Ile401Val Single submitter ⚠
- p.Leu108Phe Single submitter ⚠
- p.Leu225Pro Single submitter ⚠
- p.Leu333Phe Single submitter ⚠
- p.Leu359Phe Single submitter ⚠
- p.Leu416Arg Single submitter ⚠
- p.Leu7Gln Single submitter ⚠
- p.Lys339Gln Single submitter ⚠
- p.Lys344Asn Single submitter ⚠
- p.Lys513Glu Single submitter ⚠
- p.Met267Val Single submitter ⚠
- p.Met273Thr Single submitter ⚠
- p.Phe245Leu Single submitter ⚠
- p.Pro241Leu Single submitter ⚠
- p.Pro241Thr Single submitter ⚠
- p.Pro457Arg Single submitter ⚠
- p.Pro457Leu Single submitter ⚠
- p.Pro478Arg Single submitter ⚠
- p.Pro478Thr Single submitter ⚠
- p.Pro502Ala Single submitter ⚠
- p.Pro502Leu Single submitter ⚠
- p.Ser153Leu Single submitter ⚠
- p.Ser18Arg Single submitter ⚠
- p.Ser19Arg Single submitter ⚠
- p.Ser331Asn Single submitter ⚠
- p.Ser492Arg Single submitter ⚠
- p.Ser67Arg Single submitter ⚠
- p.Ser74Arg Single submitter ⚠
- p.Ser8Arg Single submitter ⚠
- p.Thr189Ser Single submitter ⚠
- p.Thr313Lys Single submitter ⚠
- p.Thr477Ala Single submitter ⚠
- p.Thr477Arg Single submitter ⚠
- p.Thr508Ser Single submitter ⚠
- p.Val111Met Single submitter ⚠
- p.Val175Met Single submitter ⚠
- p.Val227Leu Single submitter ⚠
- p.Val260Met Single submitter ⚠
- p.Val292Ile Single submitter ⚠
- p.Val358Leu Single submitter ⚠
- p.Val397Met Single submitter ⚠
- p.Val514Ala Single submitter ⚠
- p.Val81Leu Single submitter ⚠