ADRA2A — 74 ClinVar variants
All ClinVar germline ADRA2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
1 Pathogenic · 3 Benign · 7 Likely benign · 63 Uncertain significance
Full ADRA2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADRA2A p.Ala291Thr Uncertain significance Single submitter
- ADRA2A p.Ala291Val Uncertain significance Single submitter
- ADRA2A p.Ala338Glu Uncertain significance Single submitter
- ADRA2A p.Ala371Asp Uncertain significance Single submitter
- ADRA2A p.Ala98Thr Uncertain significance Single submitter
- ADRA2A p.Arg272Leu Uncertain significance Single submitter
- ADRA2A p.Arg331Gly Uncertain significance Single submitter
-
ADRA2A p.Asn266Asp
Uncertain significance
Single submitter
ADRA2A-related disorder
- ADRA2A p.Asn289Ser Uncertain significance Single submitter
- ADRA2A p.Cys140Arg Uncertain significance Single submitter
- ADRA2A p.Gln208Arg Uncertain significance Single submitter
- ADRA2A p.Glu204Gln Uncertain significance Single submitter
- ADRA2A p.Gly195Arg Uncertain significance Single submitter
- ADRA2A p.Gly195Ser Uncertain significance Single submitter
- ADRA2A p.Gly277Arg Uncertain significance Single submitter
- ADRA2A p.Gly299Arg Uncertain significance Single submitter
- ADRA2A p.Gly344Ser Uncertain significance Single submitter
- ADRA2A p.Gly358Arg Uncertain significance Single submitter
- ADRA2A p.Gly358Glu Uncertain significance Single submitter
- ADRA2A p.Gly365Arg Uncertain significance Single submitter
- ADRA2A p.His446Arg Uncertain significance Single submitter
- ADRA2A p.Ile123Ser Uncertain significance Single submitter
- ADRA2A p.Ile136Thr Uncertain significance Single submitter
- ADRA2A p.Ile228Val Uncertain significance Single submitter
- ADRA2A p.Ile440Val Uncertain significance Single submitter
- ADRA2A p.Phe13Leu Uncertain significance Single submitter
- ADRA2A p.Phe2Tyr Uncertain significance Single submitter
- ADRA2A p.Phe387Leu Uncertain significance Single submitter
- ADRA2A p.Pro196Arg Uncertain significance Single submitter
- ADRA2A p.Pro258Arg Uncertain significance Single submitter
- ADRA2A p.Pro364Ser Uncertain significance Single submitter
- ADRA2A p.Thr171Ala Uncertain significance Single submitter
- ADRA2A p.Thr412Lys Uncertain significance Single submitter
- ADRA2A p.Trp173Cys Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- ADRA2A p.Ala177Val Uncertain significance Single submitter
- ADRA2A p.Ala338Thr Uncertain significance Single submitter
- ADRA2A p.Arg272His Uncertain significance Single submitter
- ADRA2A p.Arg301His Uncertain significance Single submitter
- ADRA2A p.Arg331Trp Uncertain significance Single submitter
- ADRA2A p.Arg458Gln Uncertain significance Single submitter
- ADRA2A p.Asn206Ile Uncertain significance Single submitter
- ADRA2A p.Glu155Lys Likely benign Single submitter
- ADRA2A p.Gly195Asp Uncertain significance Single submitter
- ADRA2A p.Gly269Asp Uncertain significance Single submitter
- ADRA2A p.Gly278Asp Uncertain significance Single submitter
- ADRA2A p.Gly30Glu Uncertain significance Single submitter
- ADRA2A p.Gly35Arg Uncertain significance Single submitter
- ADRA2A p.Gly35Glu Uncertain significance Single submitter
- ADRA2A p.Gly459Glu Uncertain significance Single submitter
- ADRA2A p.Gly56Val Uncertain significance Single submitter
- ADRA2A p.Ile123Leu Uncertain significance Single submitter
- ADRA2A p.Ile234Val Uncertain significance Single submitter
- ADRA2A p.Leu158Val Uncertain significance Single submitter
- ADRA2A p.Leu85Phe Uncertain significance Single submitter
- ADRA2A p.Lys118Glu Uncertain significance Single submitter
- ADRA2A p.Pro246Ala Uncertain significance Single submitter
- ADRA2A p.Pro257Leu Uncertain significance Single submitter
- ADRA2A p.Pro297Ser Uncertain significance Single submitter
- ADRA2A p.Pro326Ser Uncertain significance Single submitter
- ADRA2A p.Pro348Leu Uncertain significance Single submitter
- ADRA2A p.Pro364Leu Uncertain significance Single submitter
- ADRA2A p.Thr355Met Uncertain significance Single submitter
- ADRA2A p.Val47Met Uncertain significance Single submitter
-
ADRA2A p.Leu100Phe
Uncertain significance
No assertion criteria
ADRA2A-related disorder
All ADRA2A variants
Pathogenic 1
- p.Leu68Phe No assertion criteria lipodystrophy, familial partial, type 8
Likely benign 7
- c.-1252G>C Single submitter
- p.Ala354Glu Single submitter
- p.Arg301Ser Single submitter lipodystrophy, familial partial, type 8
- p.Glu155Lys Single submitter ⚠
- p.Glu271_Pro276del Single submitter
- p.Glu280= No assertion criteria ADRA2A-related disorder
- p.Ser214= No assertion criteria ADRA2A-related disorder
Uncertain significance 63
- p.Ala177Val Single submitter ⚠
- p.Ala291Thr Single submitter ⚠
- p.Ala291Val Single submitter ⚠
- p.Ala338Glu Single submitter ⚠
- p.Ala338Thr Single submitter ⚠
- p.Ala371Asp Single submitter ⚠
- p.Ala98Thr Single submitter ⚠
- p.Arg272His Single submitter ⚠
- p.Arg272Leu Single submitter ⚠
- p.Arg301His Single submitter ⚠
- p.Arg331Gly Single submitter ⚠
- p.Arg331Trp Single submitter ⚠
- p.Arg458Gln Single submitter ⚠
- p.Asn206Ile Single submitter ⚠
- p.Asn266Asp Single submitter ADRA2A-related disorder ⚠
- p.Asn289Ser Single submitter ⚠
- p.Cys140Arg Single submitter ⚠
- p.Gln208Arg Single submitter ⚠
- p.Glu204Gln Single submitter ⚠
- p.Gly195Arg Single submitter ⚠
- p.Gly195Asp Single submitter ⚠
- p.Gly195Ser Single submitter ⚠
- p.Gly269Asp Single submitter ⚠
- p.Gly277Arg Single submitter ⚠
- p.Gly278Asp Single submitter ⚠
- p.Gly299Arg Single submitter ⚠
- p.Gly30Glu Single submitter ⚠
- p.Gly344Ser Single submitter ⚠
- p.Gly358Arg Single submitter ⚠
- p.Gly358Glu Single submitter ⚠
- p.Gly35Arg Single submitter ⚠
- p.Gly35Glu Single submitter ⚠
- p.Gly365Arg Single submitter ⚠
- p.Gly459Glu Single submitter ⚠
- p.Gly56Val Single submitter ⚠
- p.His446Arg Single submitter ⚠
- p.Ile123Leu Single submitter ⚠
- p.Ile123Ser Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile228Val Single submitter ⚠
- p.Ile234Val Single submitter ⚠
- p.Ile440Val Single submitter ⚠
- p.Leu158Val Single submitter ⚠
- p.Leu85Phe Single submitter ⚠
- p.Lys118Glu Single submitter ⚠
- p.Phe13Leu Single submitter ⚠
- p.Phe2Tyr Single submitter ⚠
- p.Phe387Leu Single submitter ⚠
- p.Pro196Arg Single submitter ⚠
- p.Pro246Ala Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro258Arg Single submitter ⚠
- p.Pro297Ser Single submitter ⚠
- p.Pro326Ser Single submitter ⚠
- p.Pro348Leu Single submitter ⚠
- p.Pro364Leu Single submitter ⚠
- p.Pro364Ser Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Thr355Met Single submitter ⚠
- p.Thr412Lys Single submitter ⚠
- p.Trp173Cys Single submitter ⚠
- p.Val47Met Single submitter ⚠
- p.Leu100Phe No assertion criteria ADRA2A-related disorder ⚠