ADRA2C — 83 ClinVar variants
All ClinVar germline ADRA2C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Conflicting · 4 Benign · 11 Likely benign · 67 Uncertain significance
Full ADRA2C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADRA2C p.Ala115Thr Uncertain significance Single submitter
- ADRA2C p.Ala16Val Uncertain significance Single submitter
- ADRA2C p.Ala198Asp Uncertain significance Single submitter
- ADRA2C p.Ala20Val Uncertain significance Single submitter
- ADRA2C p.Ala249Gly Uncertain significance Single submitter
- ADRA2C p.Ala266Val Uncertain significance Single submitter
- ADRA2C p.Ala268Val Uncertain significance Single submitter
- ADRA2C p.Ala292Pro Uncertain significance Single submitter
- ADRA2C p.Ala2Val Uncertain significance Single submitter
- ADRA2C p.Ala318Gly Uncertain significance Single submitter
- ADRA2C p.Ala332Pro Uncertain significance Single submitter
- ADRA2C p.Ala332Thr Uncertain significance Single submitter
- ADRA2C p.Ala332Val Uncertain significance Single submitter
- ADRA2C p.Ala348Thr Uncertain significance Single submitter
- ADRA2C p.Ala34Ser Uncertain significance Single submitter
- ADRA2C p.Ala34Thr Uncertain significance Single submitter
- ADRA2C p.Ala37Ser Uncertain significance Single submitter
- ADRA2C p.Ala56Val Uncertain significance Single submitter
- ADRA2C p.Ala7Val Uncertain significance Single submitter
- ADRA2C p.Ala9Gly Uncertain significance Single submitter
- ADRA2C p.Arg235Gln Uncertain significance Single submitter
- ADRA2C p.Arg294Lys Uncertain significance Single submitter
- ADRA2C p.Arg303Gln Uncertain significance Single submitter
- ADRA2C p.Arg308Gln Uncertain significance Single submitter
- ADRA2C p.Asp195Glu Uncertain significance Single submitter
- ADRA2C p.Asp254Val Uncertain significance Single submitter
- ADRA2C p.Asp286Glu Uncertain significance Single submitter
- ADRA2C p.Asp319Ala Uncertain significance Single submitter
- ADRA2C p.Asp319Gly Uncertain significance Single submitter
- ADRA2C p.Cys368Tyr Uncertain significance Single submitter
- ADRA2C p.Gln121Arg Uncertain significance Single submitter
- ADRA2C p.Gln45Arg Uncertain significance Single submitter
- ADRA2C p.Glu287Gln Uncertain significance Single submitter
- ADRA2C p.Glu293Gln Uncertain significance Single submitter
- ADRA2C p.Glu312Asp Uncertain significance Single submitter
- ADRA2C p.Gly263Arg Uncertain significance Single submitter
- ADRA2C p.Gly274Arg Uncertain significance Single submitter
- ADRA2C p.Gly313Arg Uncertain significance Single submitter
- ADRA2C p.Gly314Ala Uncertain significance Single submitter
- ADRA2C p.Gly324Glu Uncertain significance Single submitter
- ADRA2C p.Gly342Ser Uncertain significance Single submitter
- ADRA2C p.Gly342Val Uncertain significance Single submitter
- ADRA2C p.Gly40Glu Uncertain significance Single submitter
- ADRA2C p.Leu244Arg Uncertain significance Single submitter
- ADRA2C p.Leu393Ile Uncertain significance Single submitter
- ADRA2C p.Lys371Arg Uncertain significance Single submitter
- ADRA2C p.Pro280Ser Uncertain significance Single submitter
- ADRA2C p.Pro285Leu Uncertain significance Single submitter
- ADRA2C p.Pro417Thr Uncertain significance Single submitter
- ADRA2C p.Pro4Gln Uncertain significance Single submitter
- ADRA2C p.Ser289Arg Uncertain significance Single submitter
- ADRA2C p.Thr259Ala Uncertain significance Single submitter
- ADRA2C p.Thr260Ala Uncertain significance Single submitter
- ADRA2C p.Val353Leu Uncertain significance Single submitter
- ADRA2C p.Val57Ala Uncertain significance Single submitter
- ADRA2C p.Val67Ala Uncertain significance Single submitter
- ADRA2C p.Val70Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ADRA2C p.Arg362Trp Uncertain significance Single submitter
- ADRA2C p.Arg370Cys Uncertain significance Single submitter
- ADRA2C p.Asn160Thr Uncertain significance Single submitter
- ADRA2C p.Lys449Glu Uncertain significance Single submitter
- ADRA2C p.Ser336Phe Uncertain significance Single submitter
- ADRA2C p.Ser336Tyr Uncertain significance Single submitter
- ADRA2C p.Ser35Leu Uncertain significance Single submitter
- ADRA2C p.Ser366Arg Uncertain significance Single submitter
- ADRA2C p.Val236Ala Uncertain significance Single submitter
- ADRA2C p.Val392Met Uncertain significance Single submitter
All ADRA2C variants
Conflicting classifications of pathogenicity 1
- p.Pro41Leu Single submitter ⚠
Benign 4
- p.Ala332= No assertion criteria ADRA2C-related disorder
- p.Gly324_Ala327del No assertion criteria
- p.Gly389= No assertion criteria ADRA2C-related disorder
- p.Pro339Ser No assertion criteria ADRA2C-related disorder
Likely benign 11
- p.Ala311= Multiple submitters
- p.Arg303= Single submitter
- p.Arg379= Single submitter
- p.Gln86= Single submitter
- p.Gly313= Single submitter
- p.Gly317= Single submitter
- p.Gly324= Single submitter
- p.Phe440= Single submitter
- p.313GGA[1] No assertion criteria ADRA2C-related disorder
- p.Leu99= No assertion criteria ADRA2C-related disorder
- p.Val104= No assertion criteria ADRA2C-related disorder
Uncertain significance 67
- p.Ala115Thr Single submitter ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala198Asp Single submitter ⚠
- p.Ala20Val Single submitter ⚠
- p.Ala249Gly Single submitter ⚠
- p.Ala266Val Single submitter ⚠
- p.Ala268Val Single submitter ⚠
- p.Ala292Pro Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala318Gly Single submitter ⚠
- p.Ala332Pro Single submitter ⚠
- p.Ala332Thr Single submitter ⚠
- p.Ala332Val Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Ala34Ser Single submitter ⚠
- p.Ala34Thr Single submitter ⚠
- p.Ala37Ser Single submitter ⚠
- p.Ala56Val Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Ala9Gly Single submitter ⚠
- p.Arg235Gln Single submitter ⚠
- p.Arg294Lys Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg362Trp Single submitter ⚠
- p.Arg370Cys Single submitter ⚠
- p.Asn160Thr Single submitter ⚠
- p.Asp195Glu Single submitter ⚠
- p.Asp254Val Single submitter ⚠
- p.Asp286Glu Single submitter ⚠
- p.Asp319Ala Single submitter ⚠
- p.Asp319Gly Single submitter ⚠
- p.Cys368Tyr Single submitter ⚠
- p.Gln121Arg Single submitter ⚠
- p.Gln45Arg Single submitter ⚠
- p.Glu287Gln Single submitter ⚠
- p.Glu293Gln Single submitter ⚠
- p.Glu312Asp Single submitter ⚠
- p.Gly263Arg Single submitter ⚠
- p.Gly274Arg Single submitter ⚠
- p.Gly313Arg Single submitter ⚠
- p.Gly314Ala Single submitter ⚠
- p.Gly324Glu Single submitter ⚠
- p.Gly342Ser Single submitter ⚠
- p.Gly342Val Single submitter ⚠
- p.Gly40Glu Single submitter ⚠
- p.Leu244Arg Single submitter ⚠
- p.Leu393Ile Single submitter ⚠
- p.Lys371Arg Single submitter ⚠
- p.Lys449Glu Single submitter ⚠
- p.Pro280Ser Single submitter ⚠
- p.Pro285Leu Single submitter ⚠
- p.Pro417Thr Single submitter ⚠
- p.Pro4Gln Single submitter ⚠
- p.Ser289Arg Single submitter ⚠
- p.Ser336Phe Single submitter ⚠
- p.Ser336Tyr Single submitter ⚠
- p.Ser35Leu Single submitter ⚠
- p.Ser366Arg Single submitter ⚠
- p.Thr259Ala Single submitter ⚠
- p.Thr260Ala Single submitter ⚠
- p.Val236Ala Single submitter ⚠
- p.Val353Leu Single submitter ⚠
- p.Val392Met Single submitter ⚠
- p.Val57Ala Single submitter ⚠
- p.Val67Ala Single submitter ⚠
- p.Val70Leu Single submitter ⚠