ADRB1 — 80 ClinVar variants

All ClinVar germline ADRB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →

1 Pathogenic · 8 Benign · 1 Benign/Likely benign · 13 Likely benign · 57 Uncertain significance

Full ADRB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 55

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

ADRB1 p.Ala187Val Pathogenic No assertion criteria
SHORT SLEEP, FAMILIAL NATURAL, 2

Predictors lean, ClinVar uncertain 47

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 7

The independent predictors disagree with each other — read with care.

All ADRB1 variants

Pathogenic 1

p.Ala187Val No assertion criteria SHORT SLEEP, FAMILIAL NATURAL, 2 ⚠

Benign 8

p.Asp382Gly Multiple submitters
p.Cys180= Multiple submitters
p.Leu105= Multiple submitters
p.Val5Ala Multiple submitters
p.Val69= Multiple submitters
p.Ala270Thr Single submitter
p.Gly389Val Single submitter
p.Pro355= Single submitter

Benign/Likely benign 1

p.Asn76= Multiple submitters

Likely benign 13

p.Ser49Gly Multiple submitters
p.Ala297del Single submitter
p.Ala449= Single submitter
p.Arg399= Single submitter
p.Asn452= Single submitter
p.Gly115= Single submitter
p.Gly267Ser Single submitter
p.Phe130= Single submitter
p.Pro38= Single submitter
p.Pro440= Single submitter
p.Ser278= Single submitter
p.Thr439= Single submitter
p.Gly413= No assertion criteria ADRB1-related disorder

Uncertain significance 57

p.Ala227Ser Single submitter ⚠
p.Ala270Glu Single submitter ⚠
p.Ala27Val Single submitter ⚠
p.Ala284Thr Single submitter ⚠
p.Ala348Ser Single submitter ⚠
p.Ala394Ser Single submitter ⚠
p.Ala398Thr Single submitter ⚠
p.Ala457Gly Single submitter ⚠
p.Ala66Thr Single submitter ⚠
p.Ala84Val Single submitter ⚠
p.Arg174Gln Single submitter
p.Arg176Gln Single submitter ⚠
p.Arg208Cys Single submitter ⚠
p.Arg246Gln Single submitter ⚠
p.Arg305Pro Single submitter ⚠
p.Arg309Trp Single submitter ⚠
p.Arg313Pro Single submitter
p.Arg395His Single submitter ⚠
p.Arg400Trp Single submitter ⚠
p.Asn15Ser Single submitter ⚠
p.Asn369Ser Single submitter ⚠
p.Asp24Ala Single submitter ⚠
p.Asp24His Single submitter ⚠
p.Asp429Glu Single submitter ⚠
p.Cys414Ser Single submitter ⚠
p.Glu12Ala Single submitter ⚠
p.Gly122Ser Single submitter
p.Gly14Ser Single submitter ⚠
p.Gly177Cys Single submitter ⚠
p.Gly25Cys Single submitter ⚠
p.Gly267Asp Single submitter ⚠
p.Gly288Arg Single submitter ⚠
p.Gly419Arg Single submitter ⚠
p.Ile160Asn Single submitter ⚠
p.Leu32Arg Single submitter ⚠
p.Leu415Val Single submitter ⚠
p.Leu67Val Single submitter ⚠
p.Phe129Leu Single submitter ⚠
p.Pro113Arg Single submitter ⚠
p.Pro113Ser Single submitter ⚠
p.Pro275Leu Single submitter ⚠
p.Pro275Ser Single submitter ⚠
p.Pro283Ser Single submitter ⚠
p.Pro289Ser Single submitter ⚠
p.Pro311Thr Single submitter ⚠
p.Pro35Leu Single submitter ⚠
p.Pro447Ala Single submitter ⚠
p.Ser145Ile Single submitter ⚠
p.Ser278Thr Single submitter ⚠
p.Ser41Leu Single submitter ⚠
p.Ser41Trp Single submitter ⚠
p.Ser461Leu Single submitter ⚠
p.Thr28Ser Single submitter ⚠
p.Thr439Lys Single submitter ⚠
p.Thr58Ile Single submitter ⚠
p.Tyr157His Single submitter ⚠
p.Val436Phe Single submitter ⚠