ADRB2 — 36 ClinVar variants
All ClinVar germline ADRB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
19 Benign · 6 Likely benign · 11 Uncertain significance
Full ADRB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 8
The independent predictors disagree with each other — read with care.
- ADRB2 p.Arg328Trp Uncertain significance Single submitter
- ADRB2 p.Asn187Ser Likely benign Single submitter
- ADRB2 p.Asn69Ser Benign Single submitter
- ADRB2 p.Glu62Asp Uncertain significance Single submitter
-
ADRB2 p.Gly5Arg
Uncertain significance
Single submitter
ADRB2-related disorder
- ADRB2 p.Ile169Val Uncertain significance Single submitter
- ADRB2 p.Lys140Asn Uncertain significance Single submitter
- ADRB2 p.Thr136Ile Uncertain significance Single submitter
All ADRB2 variants
Benign 19
- c.-20C>T Single submitter
- c.-47C>T Single submitter
- c.*25_*26insG Single submitter
- c.*32_*33insGC Single submitter
- c.*33_*34insGCC Single submitter
- c.*34del Single submitter
- c.*34dup Single submitter
- p.Arg175= Single submitter
- p.Asn69Ser Single submitter ⚠
- p.Glu27= Single submitter
- p.Gly16= Single submitter
- p.Gly351= Single submitter
- p.His22= Single submitter
- p.Leu413= Single submitter
- p.Leu84= Single submitter
- p.Ser220Cys Single submitter
- p.Thr164Ile Single submitter
- p.Thr393= Single submitter
- p.Tyr366= Single submitter
Likely benign 6
Uncertain significance 11
- p.Ala19Glu Single submitter ⚠
- p.Arg328Trp Single submitter ⚠
- p.Gln3Lys Single submitter ⚠
- p.Glu62Asp Single submitter ⚠
- p.Gly389Asp Single submitter ⚠
- p.Gly5Arg Single submitter ADRB2-related disorder ⚠
- p.Ile169Val Single submitter ⚠
- p.Leu340Arg Single submitter ⚠
- p.Lys140Asn Single submitter ⚠
- p.Thr136Ile Single submitter ⚠
- p.Val292Asp Single submitter ⚠