ADRB3 — 68 ClinVar variants
All ClinVar germline ADRB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
7 Benign · 4 Likely benign · 57 Uncertain significance
Full ADRB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
ADRB3 p.Lys151Arg
Uncertain significance
Multiple submitters
obesity disorder
- ADRB3 p.Ala132Asp Uncertain significance Single submitter
- ADRB3 p.Ala184Pro Uncertain significance Single submitter
- ADRB3 p.Ala374Ser Uncertain significance Single submitter
- ADRB3 p.Ala374Thr Uncertain significance Single submitter
- ADRB3 p.Ala375Pro Uncertain significance Single submitter
- ADRB3 p.Ala42Val Uncertain significance Single submitter
- ADRB3 p.Ala61Asp Uncertain significance Single submitter
- ADRB3 p.Arg256Leu Uncertain significance Single submitter
- ADRB3 p.Asn73Tyr Uncertain significance Single submitter
- ADRB3 p.Asp117Glu Uncertain significance Single submitter
- ADRB3 p.Cys110Tyr Uncertain significance Single submitter
- ADRB3 p.Cys129Tyr Uncertain significance Single submitter
- ADRB3 p.Cys275Ser Uncertain significance Single submitter
- ADRB3 p.Glu248Gln Uncertain significance Single submitter
- ADRB3 p.Gly101Val Uncertain significance Single submitter
- ADRB3 p.Gly146Ser Uncertain significance Single submitter
- ADRB3 p.Gly383Asp Uncertain significance Single submitter
- ADRB3 p.His190Gln Uncertain significance Single submitter
- ADRB3 p.His6Tyr Uncertain significance Single submitter
- ADRB3 p.Leu317Val Uncertain significance Single submitter
- ADRB3 p.Leu68Phe Uncertain significance Single submitter
- ADRB3 p.Phe213Ser Uncertain significance Single submitter
- ADRB3 p.Pro262Arg Uncertain significance Single submitter
- ADRB3 p.Pro262Ser Uncertain significance Single submitter
- ADRB3 p.Pro279Ser Uncertain significance Single submitter
- ADRB3 p.Pro343Ala Uncertain significance Single submitter
- ADRB3 p.Pro343Arg Uncertain significance Single submitter
- ADRB3 p.Tyr346Cys Uncertain significance Single submitter
- ADRB3 p.Val60Leu Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- ADRB3 p.Arg353Cys Benign Multiple submitters
-
ADRB3 p.Asn338Ser
Uncertain significance
Multiple submitters
obesity disorder
- ADRB3 p.Ala130Thr Uncertain significance Single submitter
- ADRB3 p.Ala154Ser Uncertain significance Single submitter
- ADRB3 p.Ala21Glu Uncertain significance Single submitter
- ADRB3 p.Ala231Val Uncertain significance Single submitter
- ADRB3 p.Ala267Asp Uncertain significance Single submitter
- ADRB3 p.Ala355Thr Uncertain significance Single submitter
- ADRB3 p.Ala42Asp Uncertain significance Single submitter
- ADRB3 p.Ala63Val Uncertain significance Single submitter
- ADRB3 p.Arg233Ser Uncertain significance Single submitter
- ADRB3 p.Arg236Pro Uncertain significance Single submitter
- ADRB3 p.Arg362Pro Uncertain significance Single submitter
- ADRB3 p.Asp351Glu Uncertain significance Single submitter
- ADRB3 p.Cys153Phe Uncertain significance Single submitter
- ADRB3 p.Gly325Ser Likely benign Single submitter
- ADRB3 p.Ile125Thr Uncertain significance Single submitter
- ADRB3 p.Leu143Pro Uncertain significance Single submitter
- ADRB3 p.Leu17Phe Uncertain significance Single submitter
- ADRB3 p.Leu329Phe Uncertain significance Single submitter
- ADRB3 p.Leu334Ile Uncertain significance Single submitter
- ADRB3 p.Leu57Val Uncertain significance Single submitter
- ADRB3 p.Pro193Arg Uncertain significance Single submitter
- ADRB3 p.Pro252Leu Uncertain significance Single submitter
- ADRB3 p.Pro262Gln Uncertain significance Single submitter
- ADRB3 p.Pro326Ser Uncertain significance Single submitter
- ADRB3 p.Pro377Leu Uncertain significance Single submitter
- ADRB3 p.Thr72Ser Uncertain significance Single submitter
- ADRB3 p.Trp177Arg Uncertain significance Single submitter
All ADRB3 variants
Benign 7
- c.1205+14G>T Multiple submitters
- c.1206-96A>G Multiple submitters
- c.*250G>C Multiple submitters
- p.Arg353Cys Multiple submitters ⚠
- p.Trp64Arg Multiple submitters obesity disorder
- c.1205+307dup Single submitter
- p.Pro18= Single submitter
Likely benign 4
- p.Ala37Val Single submitter
- p.Gly276Cys Single submitter
- p.Gly325Ser Single submitter ⚠
- p.Pro326= Single submitter
Uncertain significance 57
- p.Asn338Ser Multiple submitters obesity disorder ⚠
- p.Lys151Arg Multiple submitters obesity disorder ⚠
- p.Ala130Thr Single submitter ⚠
- p.Ala132Asp Single submitter ⚠
- p.Ala154Ser Single submitter ⚠
- p.Ala184Pro Single submitter ⚠
- p.Ala21Glu Single submitter ⚠
- p.Ala231Val Single submitter ⚠
- p.Ala267Asp Single submitter ⚠
- p.Ala355Thr Single submitter ⚠
- p.Ala374Ser Single submitter ⚠
- p.Ala374Thr Single submitter ⚠
- p.Ala375Pro Single submitter ⚠
- p.Ala42Asp Single submitter ⚠
- p.Ala42Val Single submitter ⚠
- p.Ala61Asp Single submitter ⚠
- p.Ala63Val Single submitter ⚠
- p.Arg233Ser Single submitter ⚠
- p.Arg236Pro Single submitter ⚠
- p.Arg256Leu Single submitter ⚠
- p.Arg362Pro Single submitter ⚠
- p.Asn73Tyr Single submitter ⚠
- p.Asp117Glu Single submitter ⚠
- p.Asp351Glu Single submitter ⚠
- p.Cys110Tyr Single submitter ⚠
- p.Cys129Tyr Single submitter ⚠
- p.Cys153Phe Single submitter ⚠
- p.Cys275Ser Single submitter ⚠
- p.Glu248Gln Single submitter ⚠
- p.Gly101Val Single submitter ⚠
- p.Gly146Ser Single submitter ⚠
- p.Gly383Asp Single submitter ⚠
- p.His190Gln Single submitter ⚠
- p.His6Tyr Single submitter ⚠
- p.Ile125Thr Single submitter ⚠
- p.Leu143Pro Single submitter ⚠
- p.Leu17Phe Single submitter ⚠
- p.Leu317Val Single submitter ⚠
- p.Leu329Phe Single submitter ⚠
- p.Leu334Ile Single submitter ⚠
- p.Leu57Val Single submitter ⚠
- p.Leu68Phe Single submitter ⚠
- p.Phe213Ser Single submitter ⚠
- p.Pro193Arg Single submitter ⚠
- p.Pro252Leu Single submitter ⚠
- p.Pro262Arg Single submitter ⚠
- p.Pro262Gln Single submitter ⚠
- p.Pro262Ser Single submitter ⚠
- p.Pro279Ser Single submitter ⚠
- p.Pro326Ser Single submitter ⚠
- p.Pro343Ala Single submitter ⚠
- p.Pro343Arg Single submitter ⚠
- p.Pro377Leu Single submitter ⚠
- p.Thr72Ser Single submitter ⚠
- p.Trp177Arg Single submitter ⚠
- p.Tyr346Cys Single submitter ⚠
- p.Val60Leu Single submitter ⚠