ADSS2 — 41 ClinVar variants
All ClinVar germline ADSS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Likely benign · 39 Uncertain significance
Full ADSS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADSS2 p.Ala390Val Uncertain significance Single submitter
- ADSS2 p.Ala417Ser Uncertain significance Single submitter
- ADSS2 p.Asn409Lys Uncertain significance Single submitter
- ADSS2 p.Asn90Lys Uncertain significance Single submitter
- ADSS2 p.Asp17Asn Uncertain significance Single submitter
- ADSS2 p.Asp381Asn Uncertain significance Single submitter
- ADSS2 p.Asp53Glu Uncertain significance Single submitter
- ADSS2 p.Cys274Ser Uncertain significance Single submitter
- ADSS2 p.Gly190Ser Uncertain significance Single submitter
- ADSS2 p.Gly19Ser Uncertain significance Single submitter
- ADSS2 p.Gly26Ala Uncertain significance Single submitter
- ADSS2 p.Ile227Ser Uncertain significance Single submitter
- ADSS2 p.Ile317Thr Uncertain significance Single submitter
- ADSS2 p.Ile412Thr Uncertain significance Single submitter
- ADSS2 p.Leu49Val Uncertain significance Single submitter
- ADSS2 p.Met285Val Uncertain significance Single submitter
- ADSS2 p.Met368Val Uncertain significance Single submitter
- ADSS2 p.Pro246Ser Uncertain significance Single submitter
- ADSS2 p.Thr92Ile Uncertain significance Single submitter
- ADSS2 p.Tyr7Asp Uncertain significance Single submitter
- ADSS2 p.Val304Ile Uncertain significance Single submitter
- ADSS2 p.Val57Met Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- ADSS2 p.Ala349Thr Uncertain significance Single submitter
- ADSS2 p.Ala417Val Uncertain significance Single submitter
- ADSS2 p.Asp78Glu Uncertain significance Single submitter
- ADSS2 p.Gln149Arg Uncertain significance Single submitter
- ADSS2 p.Gln454Glu Uncertain significance Single submitter
- ADSS2 p.Glu435Ala Uncertain significance Single submitter
- ADSS2 p.Glu435Val Uncertain significance Single submitter
- ADSS2 p.Glu5Lys Likely benign Single submitter
- ADSS2 p.Gly16Cys Uncertain significance Single submitter
- ADSS2 p.His243Arg Uncertain significance Single submitter
- ADSS2 p.Lys219Asn Uncertain significance Single submitter
- ADSS2 p.Lys397Asn Uncertain significance Single submitter
- ADSS2 p.Phe328Leu Uncertain significance Single submitter
- ADSS2 p.Thr370Met Uncertain significance Single submitter
- ADSS2 p.Thr410Ile Uncertain significance Single submitter
- ADSS2 p.Tyr236Phe Uncertain significance Single submitter
- ADSS2 p.Val297Met Uncertain significance Single submitter
- ADSS2 p.Val376Gly Uncertain significance Single submitter
All ADSS2 variants
Uncertain significance 39
- p.Ala349Thr Single submitter ⚠
- p.Ala390Val Single submitter ⚠
- p.Ala417Ser Single submitter ⚠
- p.Ala417Val Single submitter ⚠
- p.Asn409Lys Single submitter ⚠
- p.Asn90Lys Single submitter ⚠
- p.Asp17Asn Single submitter ⚠
- p.Asp381Asn Single submitter ⚠
- p.Asp53Glu Single submitter ⚠
- p.Asp78Glu Single submitter ⚠
- p.Cys274Ser Single submitter ⚠
- p.Gln149Arg Single submitter ⚠
- p.Gln454Glu Single submitter ⚠
- p.Glu435Ala Single submitter ⚠
- p.Glu435Val Single submitter ⚠
- p.Gly16Cys Single submitter ⚠
- p.Gly190Ser Single submitter ⚠
- p.Gly19Ser Single submitter ⚠
- p.Gly26Ala Single submitter ⚠
- p.His243Arg Single submitter ⚠
- p.Ile227Ser Single submitter ⚠
- p.Ile317Thr Single submitter ⚠
- p.Ile412Thr Single submitter ⚠
- p.Leu49Val Single submitter ⚠
- p.Lys219Asn Single submitter ⚠
- p.Lys397Asn Single submitter ⚠
- p.Met285Val Single submitter ⚠
- p.Met368Val Single submitter ⚠
- p.Phe328Leu Single submitter ⚠
- p.Pro246Ser Single submitter ⚠
- p.Thr370Met Single submitter ⚠
- p.Thr410Ile Single submitter ⚠
- p.Thr92Ile Single submitter ⚠
- p.Tyr236Phe Single submitter ⚠
- p.Tyr7Asp Single submitter ⚠
- p.Val297Met Single submitter ⚠
- p.Val304Ile Single submitter ⚠
- p.Val376Gly Single submitter ⚠
- p.Val57Met Single submitter ⚠