Sugi Variant

Sugi Variant/AFF3

AFF3 — 302 ClinVar variants

All ClinVar germline AFF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 209 flagged for review →

6 Pathogenic · 1 Pathogenic/Likely pathogenic · 5 Likely pathogenic · 9 Conflicting · 13 Benign · 1 Benign/Likely benign · 56 Likely benign · 211 Uncertain significance

Full AFF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 209

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 7

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 132

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 69

The independent predictors disagree with each other — read with care.

All AFF3 variants

Pathogenic 6

Pathogenic/Likely pathogenic 1

Likely pathogenic 5

Conflicting classifications of pathogenicity 9

Benign 13

Benign/Likely benign 1

Likely benign 56

Uncertain significance 211