AGAP4 — 150 ClinVar variants
All ClinVar germline AGAP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 145 flagged for review →
6 Likely benign · 144 Uncertain significance
Full AGAP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 145
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGAP4 p.Ala41Thr Uncertain significance Single submitter
- AGAP4 p.Ala640Val Uncertain significance Single submitter
- AGAP4 p.Arg137Leu Uncertain significance Single submitter
- AGAP4 p.Arg246Gln Uncertain significance Single submitter
- AGAP4 p.Arg633Pro Uncertain significance Single submitter
- AGAP4 p.Arg68Cys Uncertain significance Single submitter
- AGAP4 p.Arg70Gln Uncertain significance Single submitter
- AGAP4 p.Asn310Ser Uncertain significance Single submitter
- AGAP4 p.Asn398Ser Uncertain significance Single submitter
- AGAP4 p.Asn409Asp Uncertain significance Single submitter
- AGAP4 p.Asp18Val Uncertain significance Single submitter
- AGAP4 p.Asp38Asn Uncertain significance Single submitter
- AGAP4 p.Asp538Asn Uncertain significance Single submitter
- AGAP4 p.Asp538Glu Uncertain significance Single submitter
- AGAP4 p.Cys376Tyr Uncertain significance Single submitter
- AGAP4 p.Gln334Arg Uncertain significance Single submitter
- AGAP4 p.Gln551Arg Uncertain significance Single submitter
- AGAP4 p.Glu30Gln Uncertain significance Single submitter
- AGAP4 p.Glu556Val Uncertain significance Single submitter
- AGAP4 p.Glu573Lys Uncertain significance Single submitter
- AGAP4 p.Gly370Arg Uncertain significance Single submitter
- AGAP4 p.Gly37Arg Uncertain significance Single submitter
- AGAP4 p.Gly622Arg Uncertain significance Single submitter
- AGAP4 p.His66Gln Uncertain significance Single submitter
- AGAP4 p.Ile156Val Uncertain significance Single submitter
- AGAP4 p.Ile375Met Uncertain significance Single submitter
- AGAP4 p.Ile543Val Uncertain significance Single submitter
- AGAP4 p.Lys203Arg Uncertain significance Single submitter
- AGAP4 p.Lys328Glu Uncertain significance Single submitter
- AGAP4 p.Lys365Arg Uncertain significance Single submitter
- AGAP4 p.Lys488Thr Uncertain significance Single submitter
- AGAP4 p.Lys557Asn Uncertain significance Single submitter
- AGAP4 p.Lys684Arg Uncertain significance Single submitter
- AGAP4 p.Lys684Asn Uncertain significance Single submitter
- AGAP4 p.Lys684Glu Uncertain significance Single submitter
- AGAP4 p.Met202Arg Uncertain significance Single submitter
- AGAP4 p.Met248Val Uncertain significance Single submitter
- AGAP4 p.Met40Thr Uncertain significance Single submitter
- AGAP4 p.Pro391Leu Uncertain significance Single submitter
- AGAP4 p.Ser110Asn Uncertain significance Single submitter
- AGAP4 p.Ser12Gly Uncertain significance Single submitter
- AGAP4 p.Ser143Asn Uncertain significance Single submitter
- AGAP4 p.Ser380Thr Uncertain significance Single submitter
- AGAP4 p.Ser508Asn Uncertain significance Single submitter
- AGAP4 p.Ser547Asn Uncertain significance Single submitter
- AGAP4 p.Thr147Ile Uncertain significance Single submitter
- AGAP4 p.Thr314Ala Uncertain significance Single submitter
- AGAP4 p.Thr369Pro Uncertain significance Single submitter
- AGAP4 p.Thr384Ile Uncertain significance Single submitter
- AGAP4 p.Trp489Cys Uncertain significance Single submitter
- AGAP4 p.Tyr159Cys Uncertain significance Single submitter
- AGAP4 p.Tyr32Cys Uncertain significance Single submitter
- AGAP4 p.Tyr32Ser Uncertain significance Single submitter
- AGAP4 p.Val13Ile Uncertain significance Single submitter
- AGAP4 p.Val615Glu Uncertain significance Single submitter
Predictors split 90
The independent predictors disagree with each other — read with care.
- AGAP4 p.Ala464Val Uncertain significance Single submitter
- AGAP4 p.Ala466Ser Uncertain significance Single submitter
- AGAP4 p.Ala627Val Uncertain significance Single submitter
- AGAP4 p.Ala655Val Uncertain significance Single submitter
- AGAP4 p.Arg249Cys Uncertain significance Single submitter
- AGAP4 p.Arg431Leu Uncertain significance Single submitter
- AGAP4 p.Arg431Trp Uncertain significance Single submitter
- AGAP4 p.Arg474Cys Uncertain significance Single submitter
- AGAP4 p.Arg512Cys Uncertain significance Single submitter
- AGAP4 p.Arg515Cys Uncertain significance Single submitter
- AGAP4 p.Arg517Gly Uncertain significance Single submitter
- AGAP4 p.Arg560Lys Uncertain significance Single submitter
- AGAP4 p.Arg568Cys Uncertain significance Single submitter
- AGAP4 p.Arg568Pro Uncertain significance Single submitter
- AGAP4 p.Arg593Gln Uncertain significance Single submitter
- AGAP4 p.Arg612Cys Uncertain significance Single submitter
- AGAP4 p.Arg612His Uncertain significance Single submitter
- AGAP4 p.Arg633Leu Uncertain significance Single submitter
- AGAP4 p.Arg653Gln Uncertain significance Single submitter
- AGAP4 p.Arg653Leu Uncertain significance Single submitter
- AGAP4 p.Arg665Trp Uncertain significance Single submitter
- AGAP4 p.Arg70Trp Uncertain significance Single submitter
- AGAP4 p.Asn541His Uncertain significance Single submitter
- AGAP4 p.Asp274Ala Uncertain significance Single submitter
- AGAP4 p.Asp599Gly Uncertain significance Single submitter
- AGAP4 p.Asp683Tyr Uncertain significance Single submitter
- AGAP4 p.Cys681Gly Uncertain significance Single submitter
- AGAP4 p.Gln419Lys Uncertain significance Single submitter
- AGAP4 p.Gln468Leu Uncertain significance Single submitter
- AGAP4 p.Gln471Leu Uncertain significance Single submitter
- AGAP4 p.Gln590Arg Uncertain significance Single submitter
- AGAP4 p.Glu430Lys Uncertain significance Single submitter
- AGAP4 p.Glu450Lys Uncertain significance Single submitter
- AGAP4 p.Glu556Lys Uncertain significance Single submitter
- AGAP4 p.Glu564Val Uncertain significance Single submitter
- AGAP4 p.Gly277Arg Uncertain significance Single submitter
- AGAP4 p.Gly550Arg Uncertain significance Single submitter
- AGAP4 p.Gly550Glu Uncertain significance Single submitter
- AGAP4 p.Gly657Val Uncertain significance Single submitter
- AGAP4 p.His422Pro Uncertain significance Single submitter
- AGAP4 p.His506Arg Uncertain significance Single submitter
- AGAP4 p.His629Tyr Uncertain significance Single submitter
- AGAP4 p.Ile284Met Uncertain significance Single submitter
- AGAP4 p.Ile438Met Uncertain significance Single submitter
- AGAP4 p.Ile442Leu Uncertain significance Single submitter
- AGAP4 p.Ile442Phe Uncertain significance Single submitter
- AGAP4 p.Ile500Val Uncertain significance Single submitter
- AGAP4 p.Ile673Thr Uncertain significance Single submitter
- AGAP4 p.Leu15Phe Uncertain significance Single submitter
- AGAP4 p.Leu313Val Uncertain significance Single submitter
- AGAP4 p.Leu333Phe Uncertain significance Single submitter
- AGAP4 p.Leu494Met Uncertain significance Single submitter
- AGAP4 p.Leu509Val Uncertain significance Single submitter
- AGAP4 p.Leu580Val Uncertain significance Single submitter
- AGAP4 p.Leu600Pro Uncertain significance Single submitter
- AGAP4 p.Leu642Phe Uncertain significance Single submitter
- AGAP4 p.Leu677Pro Uncertain significance Single submitter
- AGAP4 p.Lys405Arg Uncertain significance Single submitter
- AGAP4 p.Lys553Glu Uncertain significance Single submitter
- AGAP4 p.Lys570Arg Uncertain significance Single submitter
- AGAP4 p.Lys574Glu Uncertain significance Single submitter
- AGAP4 p.Lys574Met Uncertain significance Single submitter
- AGAP4 p.Met532Ile Uncertain significance Single submitter
- AGAP4 p.Phe576Leu Uncertain significance Single submitter
- AGAP4 p.Pro242His Uncertain significance Single submitter
- AGAP4 p.Pro393Arg Uncertain significance Single submitter
- AGAP4 p.Pro525Ala Uncertain significance Single submitter
- AGAP4 p.Ser216Cys Uncertain significance Single submitter
- AGAP4 p.Ser364Tyr Uncertain significance Single submitter
- AGAP4 p.Ser380Arg Uncertain significance Single submitter
- AGAP4 p.Ser382Pro Uncertain significance Single submitter
- AGAP4 p.Ser386Gly Uncertain significance Single submitter
- AGAP4 p.Ser386Ile Likely benign Single submitter
- AGAP4 p.Ser448Leu Uncertain significance Single submitter
- AGAP4 p.Ser452Gly Uncertain significance Single submitter
- AGAP4 p.Ser491Gly Uncertain significance Single submitter
- AGAP4 p.Ser508Gly Uncertain significance Single submitter
- AGAP4 p.Ser518Pro Uncertain significance Single submitter
- AGAP4 p.Ser586Phe Uncertain significance Single submitter
- AGAP4 p.Thr420Arg Uncertain significance Single submitter
- AGAP4 p.Thr420Met Uncertain significance Single submitter
- AGAP4 p.Thr426Met Uncertain significance Single submitter
- AGAP4 p.Thr427Ala Uncertain significance Single submitter
- AGAP4 p.Thr559Met Uncertain significance Single submitter
- AGAP4 p.Tyr663Phe Uncertain significance Single submitter
- AGAP4 p.Tyr679Ser Uncertain significance Single submitter
- AGAP4 p.Val312Met Uncertain significance Single submitter
- AGAP4 p.Val49Ile Uncertain significance Single submitter
- AGAP4 p.Val526Phe Uncertain significance Single submitter
- AGAP4 p.Val675Met Uncertain significance Single submitter
All AGAP4 variants
Likely benign 6
- p.Arg68His Single submitter
- p.Arg8Cys Single submitter
- p.Glu430= Single submitter
- p.Met202Thr Single submitter
- p.Ser386Ile Single submitter ⚠
- p.Thr357Ser Single submitter
Uncertain significance 144
- p.Ala41Thr Single submitter ⚠
- p.Ala464Val Single submitter ⚠
- p.Ala466Ser Single submitter ⚠
- p.Ala627Val Single submitter ⚠
- p.Ala640Val Single submitter ⚠
- p.Ala655Val Single submitter ⚠
- p.Arg137Leu Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg431Leu Single submitter ⚠
- p.Arg431Trp Single submitter ⚠
- p.Arg474Cys Single submitter ⚠
- p.Arg512Cys Single submitter ⚠
- p.Arg515Cys Single submitter ⚠
- p.Arg517Gly Single submitter ⚠
- p.Arg560Lys Single submitter ⚠
- p.Arg568Cys Single submitter ⚠
- p.Arg568Pro Single submitter ⚠
- p.Arg593Gln Single submitter ⚠
- p.Arg612Cys Single submitter ⚠
- p.Arg612His Single submitter ⚠
- p.Arg633Leu Single submitter ⚠
- p.Arg633Pro Single submitter ⚠
- p.Arg653Gln Single submitter ⚠
- p.Arg653Leu Single submitter ⚠
- p.Arg665Trp Single submitter ⚠
- p.Arg68Cys Single submitter ⚠
- p.Arg70Gln Single submitter ⚠
- p.Arg70Trp Single submitter ⚠
- p.Asn310Ser Single submitter ⚠
- p.Asn398Ser Single submitter ⚠
- p.Asn409Asp Single submitter ⚠
- p.Asn541His Single submitter ⚠
- p.Asp18Val Single submitter ⚠
- p.Asp274Ala Single submitter ⚠
- p.Asp38Asn Single submitter ⚠
- p.Asp538Asn Single submitter ⚠
- p.Asp538Glu Single submitter ⚠
- p.Asp599Gly Single submitter ⚠
- p.Asp683Tyr Single submitter ⚠
- p.Cys376Tyr Single submitter ⚠
- p.Cys681Gly Single submitter ⚠
- p.Gln334Arg Single submitter ⚠
- p.Gln419Lys Single submitter ⚠
- p.Gln468Leu Single submitter ⚠
- p.Gln471Leu Single submitter ⚠
- p.Gln551Arg Single submitter ⚠
- p.Gln590Arg Single submitter ⚠
- p.Glu30Gln Single submitter ⚠
- p.Glu430Lys Single submitter ⚠
- p.Glu450Lys Single submitter ⚠
- p.Glu556Lys Single submitter ⚠
- p.Glu556Val Single submitter ⚠
- p.Glu564Val Single submitter ⚠
- p.Glu573Lys Single submitter ⚠
- p.Gly277Arg Single submitter ⚠
- p.Gly370Arg Single submitter ⚠
- p.Gly37Arg Single submitter ⚠
- p.Gly550Arg Single submitter ⚠
- p.Gly550Glu Single submitter ⚠
- p.Gly622Arg Single submitter ⚠
- p.Gly657Val Single submitter ⚠
- p.His422Pro Single submitter ⚠
- p.His506Arg Single submitter ⚠
- p.His629Tyr Single submitter ⚠
- p.His66Gln Single submitter ⚠
- p.Ile156Val Single submitter ⚠
- p.Ile284Met Single submitter ⚠
- p.Ile375Met Single submitter ⚠
- p.Ile438Met Single submitter ⚠
- p.Ile442Leu Single submitter ⚠
- p.Ile442Phe Single submitter ⚠
- p.Ile500Val Single submitter ⚠
- p.Ile543Val Single submitter ⚠
- p.Ile673Thr Single submitter ⚠
- p.Leu15Phe Single submitter ⚠
- p.Leu313Val Single submitter ⚠
- p.Leu333Phe Single submitter ⚠
- p.Leu494Met Single submitter ⚠
- p.Leu509Val Single submitter ⚠
- p.Leu580Val Single submitter ⚠
- p.Leu600Pro Single submitter ⚠
- p.Leu642Phe Single submitter ⚠
- p.Leu677Pro Single submitter ⚠
- p.Lys203Arg Single submitter ⚠
- p.Lys328Glu Single submitter ⚠
- p.Lys365Arg Single submitter ⚠
- p.Lys405Arg Single submitter ⚠
- p.Lys488Thr Single submitter ⚠
- p.Lys553Glu Single submitter ⚠
- p.Lys557Asn Single submitter ⚠
- p.Lys570Arg Single submitter ⚠
- p.Lys574Glu Single submitter ⚠
- p.Lys574Met Single submitter ⚠
- p.Lys684Arg Single submitter ⚠
- p.Lys684Asn Single submitter ⚠
- p.Lys684Glu Single submitter ⚠
- p.Met202Arg Single submitter ⚠
- p.Met248Val Single submitter ⚠
- p.Met40Thr Single submitter ⚠
- p.Met532Ile Single submitter ⚠
- p.Phe576Leu Single submitter ⚠
- p.Pro242His Single submitter ⚠
- p.Pro391Leu Single submitter ⚠
- p.Pro393Arg Single submitter ⚠
- p.Pro525Ala Single submitter ⚠
- p.Ser110Asn Single submitter ⚠
- p.Ser12Gly Single submitter ⚠
- p.Ser143Asn Single submitter ⚠
- p.Ser216Cys Single submitter ⚠
- p.Ser364Tyr Single submitter ⚠
- p.Ser380Arg Single submitter ⚠
- p.Ser380Thr Single submitter ⚠
- p.Ser382Pro Single submitter ⚠
- p.Ser386Gly Single submitter ⚠
- p.Ser448Leu Single submitter ⚠
- p.Ser452Gly Single submitter ⚠
- p.Ser491Gly Single submitter ⚠
- p.Ser508Asn Single submitter ⚠
- p.Ser508Gly Single submitter ⚠
- p.Ser518Pro Single submitter ⚠
- p.Ser547Asn Single submitter ⚠
- p.Ser586Phe Single submitter ⚠
- p.Thr147Ile Single submitter ⚠
- p.Thr314Ala Single submitter ⚠
- p.Thr369Pro Single submitter ⚠
- p.Thr384Ile Single submitter ⚠
- p.Thr420Arg Single submitter ⚠
- p.Thr420Met Single submitter ⚠
- p.Thr426Met Single submitter ⚠
- p.Thr427Ala Single submitter ⚠
- p.Thr559Met Single submitter ⚠
- p.Trp489Cys Single submitter ⚠
- p.Tyr159Cys Single submitter ⚠
- p.Tyr32Cys Single submitter ⚠
- p.Tyr32Ser Single submitter ⚠
- p.Tyr663Phe Single submitter ⚠
- p.Tyr679Ser Single submitter ⚠
- p.Val13Ile Single submitter ⚠
- p.Val312Met Single submitter ⚠
- p.Val49Ile Single submitter ⚠
- p.Val526Phe Single submitter ⚠
- p.Val615Glu Single submitter ⚠
- p.Val675Met Single submitter ⚠