AGAP5 — 125 ClinVar variants
All ClinVar germline AGAP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 123 flagged for review →
2 Likely benign · 123 Uncertain significance
Full AGAP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 123
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGAP5 p.Ala195Val Uncertain significance Single submitter
- AGAP5 p.Ala397Thr Uncertain significance Single submitter
- AGAP5 p.Ala41Glu Uncertain significance Single submitter
- AGAP5 p.Ala43Val Uncertain significance Single submitter
- AGAP5 p.Arg137His Uncertain significance Single submitter
- AGAP5 p.Arg246Gln Uncertain significance Single submitter
- AGAP5 p.Arg334Gln Uncertain significance Single submitter
- AGAP5 p.Arg474Cys Uncertain significance Single submitter
- AGAP5 p.Arg474His Uncertain significance Single submitter
- AGAP5 p.Arg68Cys Uncertain significance Single submitter
- AGAP5 p.Asn310Ser Uncertain significance Single submitter
- AGAP5 p.Asp373Asn Uncertain significance Single submitter
- AGAP5 p.Asp683Glu Uncertain significance Single submitter
- AGAP5 p.Cys145Gly Uncertain significance Single submitter
- AGAP5 p.Gln141His Uncertain significance Single submitter
- AGAP5 p.Gln551Arg Uncertain significance Single submitter
- AGAP5 p.Glu227Asp Uncertain significance Single submitter
- AGAP5 p.Gly320Asp Uncertain significance Single submitter
- AGAP5 p.Gly370Arg Uncertain significance Single submitter
- AGAP5 p.Gly37Arg Uncertain significance Single submitter
- AGAP5 p.Gly37Glu Uncertain significance Single submitter
- AGAP5 p.His10Tyr Uncertain significance Single submitter
- AGAP5 p.His158Asp Uncertain significance Single submitter
- AGAP5 p.His173Asn Uncertain significance Single submitter
- AGAP5 p.His200Asn Uncertain significance Single submitter
- AGAP5 p.Ile164Val Uncertain significance Single submitter
- AGAP5 p.Ile31Thr Uncertain significance Single submitter
- AGAP5 p.Ile355Leu Uncertain significance Single submitter
- AGAP5 p.Ile67Val Uncertain significance Single submitter
- AGAP5 p.Leu642His Uncertain significance Single submitter
- AGAP5 p.Leu643Pro Uncertain significance Single submitter
- AGAP5 p.Lys401Thr Uncertain significance Single submitter
- AGAP5 p.Lys557Asn Uncertain significance Single submitter
- AGAP5 p.Met248Leu Uncertain significance Single submitter
- AGAP5 p.Met248Val Uncertain significance Single submitter
- AGAP5 p.Met40Leu Uncertain significance Single submitter
- AGAP5 p.Met498Val Uncertain significance Single submitter
- AGAP5 p.Pro103Ser Uncertain significance Single submitter
- AGAP5 p.Pro172Ser Uncertain significance Single submitter
- AGAP5 p.Pro44Ser Uncertain significance Single submitter
- AGAP5 p.Pro73Ala Uncertain significance Single submitter
- AGAP5 p.Ser134Phe Uncertain significance Single submitter
- AGAP5 p.Ser143Arg Uncertain significance Single submitter
- AGAP5 p.Ser185Gly Uncertain significance Single submitter
- AGAP5 p.Ser508Asn Uncertain significance Single submitter
- AGAP5 p.Thr484Ala Uncertain significance Single submitter
- AGAP5 p.Trp434Ser Uncertain significance Single submitter
- AGAP5 p.Val13Ile Uncertain significance Single submitter
- AGAP5 p.Val526Leu Uncertain significance Single submitter
- AGAP5 p.Val556Leu Uncertain significance Single submitter
- AGAP5 p.Val56Leu Uncertain significance Single submitter
- AGAP5 p.Val686Leu Uncertain significance Single submitter
Predictors split 71
The independent predictors disagree with each other — read with care.
- AGAP5 p.Ala444Thr Uncertain significance Single submitter
- AGAP5 p.Ala596Thr Uncertain significance Single submitter
- AGAP5 p.Ala608Thr Uncertain significance Single submitter
- AGAP5 p.Ala608Val Uncertain significance Single submitter
- AGAP5 p.Ala660Gly Uncertain significance Single submitter
- AGAP5 p.Ala664Thr Uncertain significance Single submitter
- AGAP5 p.Arg246Trp Uncertain significance Single submitter
- AGAP5 p.Arg249Cys Uncertain significance Single submitter
- AGAP5 p.Arg512Cys Uncertain significance Single submitter
- AGAP5 p.Arg565Trp Uncertain significance Single submitter
- AGAP5 p.Arg568Cys Uncertain significance Single submitter
- AGAP5 p.Arg568His Uncertain significance Single submitter
- AGAP5 p.Arg568Leu Uncertain significance Single submitter
- AGAP5 p.Arg612Cys Uncertain significance Single submitter
- AGAP5 p.Arg612His Uncertain significance Single submitter
- AGAP5 p.Arg653Gln Uncertain significance Single submitter
- AGAP5 p.Arg665Gln Uncertain significance Single submitter
- AGAP5 p.Asn102Lys Uncertain significance Single submitter
- AGAP5 p.Asn537Ser Uncertain significance Single submitter
- AGAP5 p.Asn674Thr Uncertain significance Single submitter
- AGAP5 p.Asp623Glu Uncertain significance Single submitter
- AGAP5 p.Cys449Arg Uncertain significance Single submitter
- AGAP5 p.Cys479Tyr Uncertain significance Single submitter
- AGAP5 p.Cys672Tyr Uncertain significance Single submitter
- AGAP5 p.Glu265Gln Uncertain significance Single submitter
- AGAP5 p.Glu572Asp Uncertain significance Single submitter
- AGAP5 p.Glu60Lys Uncertain significance Single submitter
- AGAP5 p.Glu684Lys Uncertain significance Single submitter
- AGAP5 p.Gly277Arg Uncertain significance Single submitter
- AGAP5 p.Gly610Asp Uncertain significance Single submitter
- AGAP5 p.His327Tyr Uncertain significance Single submitter
- AGAP5 p.Ile276Val Uncertain significance Single submitter
- AGAP5 p.Ile284Val Uncertain significance Single submitter
- AGAP5 p.Leu446Pro Uncertain significance Single submitter
- AGAP5 p.Leu509Val Uncertain significance Single submitter
- AGAP5 p.Leu575Val Uncertain significance Single submitter
- AGAP5 p.Lys264Glu Uncertain significance Single submitter
- AGAP5 p.Lys303Ile Uncertain significance Single submitter
- AGAP5 p.Lys400Gln Uncertain significance Single submitter
- AGAP5 p.Lys553Ile Uncertain significance Single submitter
- AGAP5 p.Phe113Tyr Uncertain significance Single submitter
- AGAP5 p.Phe113Val Uncertain significance Single submitter
- AGAP5 p.Pro341Arg Uncertain significance Single submitter
- AGAP5 p.Pro345Gln Uncertain significance Single submitter
- AGAP5 p.Pro387Thr Uncertain significance Single submitter
- AGAP5 p.Ser220Leu Uncertain significance Single submitter
- AGAP5 p.Ser293Arg Uncertain significance Single submitter
- AGAP5 p.Ser360Asn Uncertain significance Single submitter
- AGAP5 p.Ser378Cys Uncertain significance Single submitter
- AGAP5 p.Ser491Gly Uncertain significance Single submitter
- AGAP5 p.Ser508Thr Uncertain significance Single submitter
- AGAP5 p.Ser542Thr Uncertain significance Single submitter
- AGAP5 p.Ser547Arg Uncertain significance Single submitter
- AGAP5 p.Ser569Tyr Uncertain significance Single submitter
- AGAP5 p.Ser668Phe Uncertain significance Single submitter
- AGAP5 p.Thr202Met Uncertain significance Single submitter
- AGAP5 p.Thr241Pro Uncertain significance Single submitter
- AGAP5 p.Thr427Met Uncertain significance Single submitter
- AGAP5 p.Thr559Met Uncertain significance Single submitter
- AGAP5 p.Thr583Ala Uncertain significance Single submitter
- AGAP5 p.Thr602Arg Uncertain significance Single submitter
- AGAP5 p.Thr662Asn Uncertain significance Single submitter
- AGAP5 p.Tyr663Cys Uncertain significance Single submitter
- AGAP5 p.Val199Met Uncertain significance Single submitter
- AGAP5 p.Val24Met Uncertain significance Single submitter
- AGAP5 p.Val305Ile Uncertain significance Single submitter
- AGAP5 p.Val312Met Uncertain significance Single submitter
- AGAP5 p.Val435Ala Uncertain significance Single submitter
- AGAP5 p.Val526Phe Uncertain significance Single submitter
- AGAP5 p.Val648Leu Uncertain significance Single submitter
- AGAP5 p.Val675Glu Uncertain significance Single submitter
All AGAP5 variants
Likely benign 2
- c.396+8A>G Single submitter
- p.Ile4Thr Single submitter
Uncertain significance 123
- p.Ala195Val Single submitter ⚠
- p.Ala397Thr Single submitter ⚠
- p.Ala41Glu Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala444Thr Single submitter ⚠
- p.Ala596Thr Single submitter ⚠
- p.Ala608Thr Single submitter ⚠
- p.Ala608Val Single submitter ⚠
- p.Ala660Gly Single submitter ⚠
- p.Ala664Thr Single submitter ⚠
- p.Arg137His Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg246Trp Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg334Gln Single submitter ⚠
- p.Arg474Cys Single submitter ⚠
- p.Arg474His Single submitter ⚠
- p.Arg512Cys Single submitter ⚠
- p.Arg565Trp Single submitter ⚠
- p.Arg568Cys Single submitter ⚠
- p.Arg568His Single submitter ⚠
- p.Arg568Leu Single submitter ⚠
- p.Arg612Cys Single submitter ⚠
- p.Arg612His Single submitter ⚠
- p.Arg653Gln Single submitter ⚠
- p.Arg665Gln Single submitter ⚠
- p.Arg68Cys Single submitter ⚠
- p.Asn102Lys Single submitter ⚠
- p.Asn310Ser Single submitter ⚠
- p.Asn537Ser Single submitter ⚠
- p.Asn674Thr Single submitter ⚠
- p.Asp373Asn Single submitter ⚠
- p.Asp623Glu Single submitter ⚠
- p.Asp683Glu Single submitter ⚠
- p.Cys145Gly Single submitter ⚠
- p.Cys449Arg Single submitter ⚠
- p.Cys479Tyr Single submitter ⚠
- p.Cys672Tyr Single submitter ⚠
- p.Gln141His Single submitter ⚠
- p.Gln551Arg Single submitter ⚠
- p.Glu227Asp Single submitter ⚠
- p.Glu265Gln Single submitter ⚠
- p.Glu572Asp Single submitter ⚠
- p.Glu60Lys Single submitter ⚠
- p.Glu684Lys Single submitter ⚠
- p.Gly277Arg Single submitter ⚠
- p.Gly320Asp Single submitter ⚠
- p.Gly370Arg Single submitter ⚠
- p.Gly37Arg Single submitter ⚠
- p.Gly37Glu Single submitter ⚠
- p.Gly610Asp Single submitter ⚠
- p.His10Tyr Single submitter ⚠
- p.His158Asp Single submitter ⚠
- p.His173Asn Single submitter ⚠
- p.His200Asn Single submitter ⚠
- p.His327Tyr Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile276Val Single submitter ⚠
- p.Ile284Val Single submitter ⚠
- p.Ile31Thr Single submitter ⚠
- p.Ile355Leu Single submitter ⚠
- p.Ile67Val Single submitter ⚠
- p.Leu446Pro Single submitter ⚠
- p.Leu509Val Single submitter ⚠
- p.Leu575Val Single submitter ⚠
- p.Leu642His Single submitter ⚠
- p.Leu643Pro Single submitter ⚠
- p.Lys264Glu Single submitter ⚠
- p.Lys303Ile Single submitter ⚠
- p.Lys400Gln Single submitter ⚠
- p.Lys401Thr Single submitter ⚠
- p.Lys553Ile Single submitter ⚠
- p.Lys557Asn Single submitter ⚠
- p.Met248Leu Single submitter ⚠
- p.Met248Val Single submitter ⚠
- p.Met40Leu Single submitter ⚠
- p.Met498Val Single submitter ⚠
- p.Phe113Tyr Single submitter ⚠
- p.Phe113Val Single submitter ⚠
- p.Pro103Ser Single submitter ⚠
- p.Pro172Ser Single submitter ⚠
- p.Pro341Arg Single submitter ⚠
- p.Pro345Gln Single submitter ⚠
- p.Pro387Thr Single submitter ⚠
- p.Pro44Ser Single submitter ⚠
- p.Pro73Ala Single submitter ⚠
- p.Ser134Phe Single submitter ⚠
- p.Ser143Arg Single submitter ⚠
- p.Ser185Gly Single submitter ⚠
- p.Ser220Leu Single submitter ⚠
- p.Ser293Arg Single submitter ⚠
- p.Ser360Asn Single submitter ⚠
- p.Ser378Cys Single submitter ⚠
- p.Ser491Gly Single submitter ⚠
- p.Ser508Asn Single submitter ⚠
- p.Ser508Thr Single submitter ⚠
- p.Ser542Thr Single submitter ⚠
- p.Ser547Arg Single submitter ⚠
- p.Ser569Tyr Single submitter ⚠
- p.Ser668Phe Single submitter ⚠
- p.Thr202Met Single submitter ⚠
- p.Thr241Pro Single submitter ⚠
- p.Thr427Met Single submitter ⚠
- p.Thr484Ala Single submitter ⚠
- p.Thr559Met Single submitter ⚠
- p.Thr583Ala Single submitter ⚠
- p.Thr602Arg Single submitter ⚠
- p.Thr662Asn Single submitter ⚠
- p.Trp434Ser Single submitter ⚠
- p.Tyr663Cys Single submitter ⚠
- p.Val13Ile Single submitter ⚠
- p.Val199Met Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val305Ile Single submitter ⚠
- p.Val312Met Single submitter ⚠
- p.Val435Ala Single submitter ⚠
- p.Val526Leu Single submitter ⚠
- p.Val526Phe Single submitter ⚠
- p.Val556Leu Single submitter ⚠
- p.Val56Leu Single submitter ⚠
- p.Val648Leu Single submitter ⚠
- p.Val675Glu Single submitter ⚠
- p.Val686Leu Single submitter ⚠