AGFG2 — 69 ClinVar variants
All ClinVar germline AGFG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
4 Likely benign · 65 Uncertain significance
Full AGFG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGFG2 p.Ala221Pro Uncertain significance Single submitter
- AGFG2 p.Ala236Thr Uncertain significance Single submitter
- AGFG2 p.Ala280Thr Uncertain significance Single submitter
- AGFG2 p.Ala373Ser Uncertain significance Single submitter
- AGFG2 p.Ala389Val Uncertain significance Single submitter
- AGFG2 p.Ala414Thr Uncertain significance Single submitter
- AGFG2 p.Ala414Val Uncertain significance Single submitter
- AGFG2 p.Ala51Val Uncertain significance Single submitter
- AGFG2 p.Arg203Trp Uncertain significance Single submitter
- AGFG2 p.Asp127Tyr Uncertain significance Single submitter
- AGFG2 p.Asp439Asn Uncertain significance Single submitter
- AGFG2 p.Gln296Leu Uncertain significance Single submitter
- AGFG2 p.Gln41Arg Uncertain significance Single submitter
- AGFG2 p.Gly250Ala Uncertain significance Single submitter
- AGFG2 p.Gly351Cys Uncertain significance Single submitter
- AGFG2 p.Gly353Ser Uncertain significance Single submitter
- AGFG2 p.Gly354Ser Uncertain significance Single submitter
- AGFG2 p.Gly464Arg Uncertain significance Single submitter
- AGFG2 p.Gly54Trp Uncertain significance Single submitter
- AGFG2 p.His215Pro Uncertain significance Single submitter
- AGFG2 p.His46Gln Uncertain significance Single submitter
- AGFG2 p.Leu277Arg Uncertain significance Single submitter
- AGFG2 p.Lys444Asn Uncertain significance Single submitter
- AGFG2 p.Met88Val Uncertain significance Single submitter
- AGFG2 p.Phe249Ser Uncertain significance Single submitter
- AGFG2 p.Pro11Leu Uncertain significance Single submitter
- AGFG2 p.Pro123Ser Uncertain significance Single submitter
- AGFG2 p.Pro128Ala Uncertain significance Single submitter
- AGFG2 p.Pro147Ser Uncertain significance Single submitter
- AGFG2 p.Pro174Leu Uncertain significance Single submitter
- AGFG2 p.Pro241Thr Uncertain significance Single submitter
- AGFG2 p.Pro254Ser Uncertain significance Single submitter
- AGFG2 p.Pro371Leu Uncertain significance Single submitter
- AGFG2 p.Pro420Leu Uncertain significance Single submitter
- AGFG2 p.Pro423Ala Uncertain significance Single submitter
- AGFG2 p.Pro424Leu Uncertain significance Single submitter
- AGFG2 p.Pro479His Uncertain significance Single submitter
- AGFG2 p.Ser162Cys Uncertain significance Single submitter
- AGFG2 p.Ser194Asn Uncertain significance Single submitter
- AGFG2 p.Ser26Leu Uncertain significance Single submitter
- AGFG2 p.Thr192Ala Uncertain significance Single submitter
- AGFG2 p.Thr204Ile Uncertain significance Single submitter
- AGFG2 p.Thr223Ala Uncertain significance Single submitter
- AGFG2 p.Thr253Ile Uncertain significance Single submitter
- AGFG2 p.Thr298Ile Uncertain significance Single submitter
- AGFG2 p.Thr348Met Uncertain significance Single submitter
- AGFG2 p.Thr357Ala Uncertain significance Single submitter
- AGFG2 p.Thr410Pro Uncertain significance Single submitter
- AGFG2 p.Thr476Ser Uncertain significance Single submitter
- AGFG2 p.Thr90Ile Uncertain significance Single submitter
- AGFG2 p.Val325Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- AGFG2 p.Gly336Arg Uncertain significance Single submitter
- AGFG2 p.Gly393Asp Uncertain significance Single submitter
- AGFG2 p.Pro148Leu Uncertain significance Single submitter
- AGFG2 p.Pro343Arg Uncertain significance Single submitter
- AGFG2 p.Pro367Leu Uncertain significance Single submitter
- AGFG2 p.Ser101Tyr Uncertain significance Single submitter
- AGFG2 p.Ser276Arg Uncertain significance Single submitter
- AGFG2 p.Ser346Cys Uncertain significance Single submitter
- AGFG2 p.Ser416Tyr Uncertain significance Single submitter
- AGFG2 p.Ser451Arg Uncertain significance Single submitter
- AGFG2 p.Val33Met Uncertain significance Single submitter
- AGFG2 p.Val62Met Uncertain significance Single submitter
All AGFG2 variants
Likely benign 4
- p.Gly351Ser Single submitter
- p.Ser416Thr Single submitter
- p.Thr369Ala Single submitter
- p.Val317Met Single submitter
Uncertain significance 65
- p.Ala221Pro Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala373Ser Single submitter ⚠
- p.Ala389Val Single submitter ⚠
- p.Ala414Thr Single submitter ⚠
- p.Ala414Val Single submitter ⚠
- p.Ala51Val Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Asp127Tyr Single submitter ⚠
- p.Asp439Asn Single submitter ⚠
- p.Gln296Leu Single submitter ⚠
- p.Gln41Arg Single submitter ⚠
- p.Gly250Ala Single submitter ⚠
- p.Gly336Arg Single submitter ⚠
- p.Gly351Cys Single submitter ⚠
- p.Gly353Ser Single submitter ⚠
- p.Gly354Ser Single submitter ⚠
- p.Gly362Arg Single submitter
- p.Gly393Asp Single submitter ⚠
- p.Gly464Arg Single submitter ⚠
- p.Gly54Trp Single submitter ⚠
- p.His215Pro Single submitter ⚠
- p.His46Gln Single submitter ⚠
- p.Leu277Arg Single submitter ⚠
- p.Lys444Asn Single submitter ⚠
- p.Met88Val Single submitter ⚠
- p.Phe249Ser Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro123Ser Single submitter ⚠
- p.Pro128Ala Single submitter ⚠
- p.Pro147Ser Single submitter ⚠
- p.Pro148Leu Single submitter ⚠
- p.Pro174Leu Single submitter ⚠
- p.Pro241Thr Single submitter ⚠
- p.Pro254Ser Single submitter ⚠
- p.Pro343Arg Single submitter ⚠
- p.Pro367Leu Single submitter ⚠
- p.Pro371Leu Single submitter ⚠
- p.Pro382Leu Single submitter
- p.Pro420Leu Single submitter ⚠
- p.Pro423Ala Single submitter ⚠
- p.Pro424Leu Single submitter ⚠
- p.Pro479His Single submitter ⚠
- p.Ser101Tyr Single submitter ⚠
- p.Ser162Cys Single submitter ⚠
- p.Ser194Asn Single submitter ⚠
- p.Ser26Leu Single submitter ⚠
- p.Ser276Arg Single submitter ⚠
- p.Ser346Cys Single submitter ⚠
- p.Ser416Tyr Single submitter ⚠
- p.Ser451Arg Single submitter ⚠
- p.Thr192Ala Single submitter ⚠
- p.Thr204Ile Single submitter ⚠
- p.Thr223Ala Single submitter ⚠
- p.Thr253Ile Single submitter ⚠
- p.Thr298Ile Single submitter ⚠
- p.Thr348Met Single submitter ⚠
- p.Thr357Ala Single submitter ⚠
- p.Thr410Pro Single submitter ⚠
- p.Thr476Ser Single submitter ⚠
- p.Thr90Ile Single submitter ⚠
- p.Val325Met Single submitter ⚠
- p.Val33Met Single submitter ⚠
- p.Val62Met Single submitter ⚠