Sugi Variant

Sugi Variant/AGK

AGK — 400 ClinVar variants

All ClinVar germline AGK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 123 flagged for review →

34 Pathogenic · 4 Pathogenic/Likely pathogenic · 13 Likely pathogenic · 24 Conflicting · 24 Benign · 10 Benign/Likely benign · 145 Likely benign · 146 Uncertain significance

Full AGK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 123

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 7

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 62

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 54

The independent predictors disagree with each other — read with care.

All AGK variants

Pathogenic 34

Pathogenic/Likely pathogenic 4

Likely pathogenic 13

Conflicting classifications of pathogenicity 24

Benign 24

Benign/Likely benign 10

Likely benign 145

Uncertain significance 146