AGMAT — 67 ClinVar variants
All ClinVar germline AGMAT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
1 Likely pathogenic · 2 Benign · 4 Likely benign · 60 Uncertain significance
Full AGMAT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGMAT p.Ala10Ser Uncertain significance Single submitter
- AGMAT p.Ala186Val Uncertain significance Single submitter
- AGMAT p.Ala335Val Uncertain significance Single submitter
- AGMAT p.Arg218His Uncertain significance Single submitter
- AGMAT p.Arg31Cys Uncertain significance Single submitter
- AGMAT p.Arg31His Uncertain significance Single submitter
- AGMAT p.Asp185Glu Uncertain significance Single submitter
- AGMAT p.Asp317Gly Uncertain significance Single submitter
- AGMAT p.Cys216Ser Uncertain significance Single submitter
- AGMAT p.Gln35His Uncertain significance Single submitter
- AGMAT p.Gln65His Uncertain significance Single submitter
- AGMAT p.Gly268Arg Uncertain significance Single submitter
- AGMAT p.Gly268Asp Uncertain significance Single submitter
- AGMAT p.Gly295Arg Uncertain significance Single submitter
- AGMAT p.Gly315Asp Uncertain significance Single submitter
- AGMAT p.Gly77Arg Uncertain significance Single submitter
- AGMAT p.Gly8Arg Uncertain significance Single submitter
- AGMAT p.Gly93Arg Uncertain significance Single submitter
- AGMAT p.Ile273Val Uncertain significance Single submitter
- AGMAT p.Ile97Thr Uncertain significance Single submitter
- AGMAT p.Leu199Ile Uncertain significance Single submitter
- AGMAT p.Leu318Pro Uncertain significance Single submitter
- AGMAT p.Leu339Pro Uncertain significance Single submitter
- AGMAT p.Leu4Arg Uncertain significance Single submitter
- AGMAT p.Pro28Ala Uncertain significance Single submitter
- AGMAT p.Ser46Asn Uncertain significance Single submitter
- AGMAT p.Val352Ile Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- AGMAT p.Ala113Asp Uncertain significance Single submitter
- AGMAT p.Ala285Val Uncertain significance Single submitter
- AGMAT p.Ala74Ser Uncertain significance Single submitter
- AGMAT p.Arg207Gln Uncertain significance Single submitter
- AGMAT p.Arg225Gln Uncertain significance Single submitter
- AGMAT p.Arg225Trp Uncertain significance Single submitter
- AGMAT p.Arg243Gln Uncertain significance Single submitter
- AGMAT p.Arg243Trp Uncertain significance Single submitter
- AGMAT p.Arg34Cys Uncertain significance Single submitter
- AGMAT p.Arg95His Uncertain significance Single submitter
- AGMAT p.Arg98Trp Uncertain significance Single submitter
- AGMAT p.Asp136Asn Uncertain significance Single submitter
- AGMAT p.Asp192Asn Uncertain significance Single submitter
- AGMAT p.Cys250Ser Uncertain significance Single submitter
- AGMAT p.Gln170His Uncertain significance Single submitter
- AGMAT p.Gly180Val Uncertain significance Single submitter
- AGMAT p.Gly202Arg Uncertain significance Single submitter
- AGMAT p.Leu114Pro Uncertain significance Single submitter
- AGMAT p.Leu134Phe Uncertain significance Single submitter
- AGMAT p.Leu214Val Uncertain significance Single submitter
- AGMAT p.Leu255Pro Uncertain significance Single submitter
- AGMAT p.Lys198Gln Uncertain significance Single submitter
- AGMAT p.Met59Val Uncertain significance Single submitter
- AGMAT p.Phe116Val Uncertain significance Single submitter
- AGMAT p.Pro257Ser Uncertain significance Single submitter
- AGMAT p.Pro324Gln Uncertain significance Single submitter
- AGMAT p.Pro68His Uncertain significance Single submitter
- AGMAT p.Pro79Leu Uncertain significance Single submitter
- AGMAT p.Ser85Cys Uncertain significance Single submitter
- AGMAT p.Thr188Met Likely benign Single submitter
- AGMAT p.Thr66Ile Uncertain significance Single submitter
- AGMAT p.Tyr325Cys Uncertain significance Single submitter
- AGMAT p.Val184Met Uncertain significance Single submitter
- AGMAT p.Val321Ile Uncertain significance Single submitter
All AGMAT variants
Likely pathogenic 1
- p.Asp161Asn No assertion criteria Moyamoya angiopathy
Benign 2
- p.Thr229Met Multiple submitters
- p.Thr351= Multiple submitters
Likely benign 4
- p.Ala10= Single submitter
- p.Leu327Pro Single submitter
- p.Pro324= Single submitter
- p.Thr188Met Single submitter ⚠
Uncertain significance 60
- p.Ala10Ser Single submitter ⚠
- p.Ala113Asp Single submitter ⚠
- p.Ala186Val Single submitter ⚠
- p.Ala285Val Single submitter ⚠
- p.Ala335Val Single submitter ⚠
- p.Ala74Ser Single submitter ⚠
- p.Arg207Gln Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg225Trp Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg243Trp Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg31His Single submitter ⚠
- p.Arg34Cys Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Arg98Trp Single submitter ⚠
- p.Asp136Asn Single submitter ⚠
- p.Asp185Glu Single submitter ⚠
- p.Asp192Asn Single submitter ⚠
- p.Asp317Gly Single submitter ⚠
- p.Cys216Ser Single submitter ⚠
- p.Cys250Ser Single submitter ⚠
- p.Gln170His Single submitter ⚠
- p.Gln35His Single submitter ⚠
- p.Gln65His Single submitter ⚠
- p.Gly180Val Single submitter ⚠
- p.Gly202Arg Single submitter ⚠
- p.Gly268Arg Single submitter ⚠
- p.Gly268Asp Single submitter ⚠
- p.Gly295Arg Single submitter ⚠
- p.Gly315Asp Single submitter ⚠
- p.Gly77Arg Single submitter ⚠
- p.Gly8Arg Single submitter ⚠
- p.Gly93Arg Single submitter ⚠
- p.Ile273Val Single submitter ⚠
- p.Ile97Thr Single submitter ⚠
- p.Leu114Pro Single submitter ⚠
- p.Leu134Phe Single submitter ⚠
- p.Leu199Ile Single submitter ⚠
- p.Leu214Val Single submitter ⚠
- p.Leu255Pro Single submitter ⚠
- p.Leu318Pro Single submitter ⚠
- p.Leu339Pro Single submitter ⚠
- p.Leu4Arg Single submitter ⚠
- p.Lys198Gln Single submitter ⚠
- p.Met59Val Single submitter ⚠
- p.Phe116Val Single submitter ⚠
- p.Pro257Ser Single submitter ⚠
- p.Pro28Ala Single submitter ⚠
- p.Pro324Gln Single submitter ⚠
- p.Pro68His Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Ser46Asn Single submitter ⚠
- p.Ser85Cys Single submitter ⚠
- p.Thr66Ile Single submitter ⚠
- p.Tyr325Cys Single submitter ⚠
- p.Val184Met Single submitter ⚠
- p.Val321Ile Single submitter ⚠
- p.Val352Ile Single submitter ⚠