AGO4 — 81 ClinVar variants
All ClinVar germline AGO4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
81 Uncertain significance
Full AGO4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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AGO4 p.Arg277Trp
Uncertain significance
Multiple submitters
AGO4-related disorder
- AGO4 p.Ala293Pro Uncertain significance Single submitter
- AGO4 p.Arg100Gln Uncertain significance Single submitter
- AGO4 p.Arg100Gly Uncertain significance Single submitter
- AGO4 p.Arg17Cys Uncertain significance Single submitter
- AGO4 p.Arg18Cys Uncertain significance Single submitter
- AGO4 p.Arg245His Uncertain significance Single submitter
- AGO4 p.Arg29Gln Uncertain significance Single submitter
- AGO4 p.Arg526His Uncertain significance Single submitter
- AGO4 p.Arg627Gln Uncertain significance Single submitter
- AGO4 p.Arg665Trp Uncertain significance Single submitter
- AGO4 p.Arg70Gln Uncertain significance Single submitter
- AGO4 p.Arg797His Uncertain significance Single submitter
- AGO4 p.Arg839Gln Uncertain significance Single submitter
- AGO4 p.Arg88Lys Uncertain significance Single submitter
- AGO4 p.Asn234Ser Uncertain significance Single submitter
- AGO4 p.Asn290Tyr Uncertain significance Single submitter
- AGO4 p.Asn423Ser Uncertain significance Single submitter
- AGO4 p.Asp146Val Uncertain significance Single submitter
- AGO4 p.Asp153Tyr Uncertain significance Single submitter
- AGO4 p.Asp721Glu Uncertain significance Single submitter
- AGO4 p.Glu143Gly Uncertain significance Single submitter
- AGO4 p.Glu176Gln Uncertain significance Single submitter
- AGO4 p.Gly254Val Uncertain significance Single submitter
- AGO4 p.Gly390Cys Uncertain significance Single submitter
- AGO4 p.His140Arg Uncertain significance Single submitter
- AGO4 p.His856Gln Uncertain significance Single submitter
- AGO4 p.His94Tyr Uncertain significance Single submitter
- AGO4 p.Ile220Val Uncertain significance Single submitter
- AGO4 p.Ile28Val Uncertain significance Single submitter
- AGO4 p.Ile98Thr Uncertain significance Single submitter
- AGO4 p.Leu531Val Uncertain significance Single submitter
- AGO4 p.Leu644Pro Uncertain significance Single submitter
- AGO4 p.Met294Val Uncertain significance Single submitter
- AGO4 p.Met378Val Uncertain significance Single submitter
- AGO4 p.Met409Val Uncertain significance Single submitter
- AGO4 p.Met68Thr Uncertain significance Single submitter
- AGO4 p.Pro198Leu Uncertain significance Single submitter
- AGO4 p.Pro313Ala Uncertain significance Single submitter
- AGO4 p.Ser161Cys Uncertain significance Single submitter
-
AGO4 p.Ser161Tyr
Uncertain significance
Single submitter
AGO4-related disorder
- AGO4 p.Ser740Asn Uncertain significance Single submitter
- AGO4 p.Ser740Thr Uncertain significance Single submitter
- AGO4 p.Tyr84Cys Uncertain significance Single submitter
- AGO4 p.Val379Met Uncertain significance Single submitter
- AGO4 p.Val511Ala Uncertain significance Single submitter
- AGO4 p.Val541Ile Uncertain significance Single submitter
- AGO4 p.Val623Leu Uncertain significance Single submitter
- AGO4 p.Val673Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- AGO4 p.Ala449Val Uncertain significance Single submitter
- AGO4 p.Arg467Cys Uncertain significance Single submitter
- AGO4 p.Arg56Gln Uncertain significance Single submitter
- AGO4 p.Arg660His Uncertain significance Single submitter
- AGO4 p.Arg839Trp Uncertain significance Single submitter
- AGO4 p.Gln322Arg Uncertain significance Single submitter
- AGO4 p.Gln324Arg Uncertain significance Single submitter
- AGO4 p.Gln433His Uncertain significance Single submitter
- AGO4 p.Gln465Glu Uncertain significance Single submitter
- AGO4 p.Gln642Arg Uncertain significance Single submitter
- AGO4 p.Gln710Lys Uncertain significance Single submitter
- AGO4 p.Gln842Glu Uncertain significance Single submitter
- AGO4 p.Glu724Gly Uncertain significance Single submitter
- AGO4 p.Gly506Ser Uncertain significance Single submitter
- AGO4 p.His180Gln Uncertain significance Single submitter
- AGO4 p.Leu372Met Uncertain significance Single submitter
- AGO4 p.Lys344Arg Uncertain significance Single submitter
- AGO4 p.Met105Thr Uncertain significance Single submitter
- AGO4 p.Pro16Leu Uncertain significance Single submitter
- AGO4 p.Pro450Leu Uncertain significance Single submitter
- AGO4 p.Thr503Ile Uncertain significance Single submitter
- AGO4 p.Thr857Met Uncertain significance Single submitter
- AGO4 p.Tyr504Phe Uncertain significance Single submitter
- AGO4 p.Val511Met Uncertain significance Single submitter
- AGO4 p.Val590Ile Uncertain significance Single submitter
All AGO4 variants
Uncertain significance 81
- p.Arg277Trp Multiple submitters AGO4-related disorder ⚠
- p.Ala293Pro Single submitter ⚠
- p.Ala449Val Single submitter ⚠
- p.Arg100Gln Single submitter ⚠
- p.Arg100Gly Single submitter ⚠
- p.Arg17Cys Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg245His Single submitter ⚠
- p.Arg29Gln Single submitter ⚠
- p.Arg415Gln Single submitter
- p.Arg467Cys Single submitter ⚠
- p.Arg467His Single submitter
- p.Arg526His Single submitter ⚠
- p.Arg56Gln Single submitter ⚠
- p.Arg627Gln Single submitter ⚠
- p.Arg660His Single submitter ⚠
- p.Arg665Trp Single submitter ⚠
- p.Arg70Gln Single submitter ⚠
- p.Arg797His Single submitter ⚠
- p.Arg839Gln Single submitter ⚠
- p.Arg839Trp Single submitter ⚠
- p.Arg88Lys Single submitter ⚠
- p.Asn234Ser Single submitter ⚠
- p.Asn290Tyr Single submitter ⚠
- p.Asn423Ser Single submitter ⚠
- p.Asp146Val Single submitter ⚠
- p.Asp153Tyr Single submitter ⚠
- p.Asp491fs Single submitter
- p.Asp721Glu Single submitter ⚠
- p.Gln322Arg Single submitter ⚠
- p.Gln324Arg Single submitter ⚠
- p.Gln433His Single submitter ⚠
- p.Gln465Glu Single submitter ⚠
- p.Gln642Arg Single submitter ⚠
- p.Gln710Lys Single submitter ⚠
- p.Gln81Ter Single submitter
- p.Gln842Glu Single submitter ⚠
- p.Glu143Gly Single submitter ⚠
- p.Glu176Gln Single submitter ⚠
- p.Glu724Gly Single submitter ⚠
- p.Gly254Val Single submitter ⚠
- p.Gly390Cys Single submitter ⚠
- p.Gly506Ser Single submitter ⚠
- p.His140Arg Single submitter ⚠
- p.His180Gln Single submitter ⚠
- p.His856Gln Single submitter ⚠
- p.His94Tyr Single submitter ⚠
- p.Ile220Val Single submitter ⚠
- p.Ile28Val Single submitter ⚠
- p.Ile98Thr Single submitter ⚠
- p.Leu372Met Single submitter ⚠
- p.Leu531Val Single submitter ⚠
- p.Leu644Pro Single submitter ⚠
- p.Lys344Arg Single submitter ⚠
- p.Met105Thr Single submitter ⚠
- p.Met294Val Single submitter ⚠
- p.Met378Val Single submitter ⚠
- p.Met409Val Single submitter ⚠
- p.Met68Thr Single submitter ⚠
- p.Pro16Ala Single submitter
- p.Pro16Leu Single submitter ⚠
- p.Pro198fs Single submitter
- p.Pro198Leu Single submitter ⚠
- p.Pro313Ala Single submitter ⚠
- p.Pro450Leu Single submitter ⚠
- p.Ser161Cys Single submitter ⚠
- p.Ser161Tyr Single submitter AGO4-related disorder ⚠
- p.Ser740Asn Single submitter ⚠
- p.Ser740Thr Single submitter ⚠
- p.Thr503Ile Single submitter ⚠
- p.Thr857Met Single submitter ⚠
- p.Trp201Gly Single submitter
- p.Tyr504Phe Single submitter ⚠
- p.Tyr84Cys Single submitter ⚠
- p.Val379Met Single submitter ⚠
- p.Val511Ala Single submitter ⚠
- p.Val511Met Single submitter ⚠
- p.Val541Ile Single submitter ⚠
- p.Val590Ile Single submitter ⚠
- p.Val623Leu Single submitter ⚠
- p.Val673Ile Single submitter ⚠