AGPAT4 — 33 ClinVar variants
All ClinVar germline AGPAT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Likely benign · 31 Uncertain significance
Full AGPAT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGPAT4 p.Ala315Gly Uncertain significance Single submitter
- AGPAT4 p.Arg199His Uncertain significance Single submitter
- AGPAT4 p.Arg303Gln Uncertain significance Single submitter
- AGPAT4 p.Arg80His Uncertain significance Single submitter
- AGPAT4 p.Asn245Ser Uncertain significance Single submitter
- AGPAT4 p.Cys270Arg Uncertain significance Single submitter
- AGPAT4 p.Glu140Lys Uncertain significance Single submitter
- AGPAT4 p.His250Asp Uncertain significance Single submitter
- AGPAT4 p.Ile75Thr Uncertain significance Single submitter
- AGPAT4 p.Ile91Val Uncertain significance Single submitter
- AGPAT4 p.Leu159Met Uncertain significance Single submitter
- AGPAT4 p.Lys153Gln Uncertain significance Single submitter
- AGPAT4 p.Lys43Thr Uncertain significance Single submitter
- AGPAT4 p.Met299Val Uncertain significance Single submitter
- AGPAT4 p.Phe323Leu Uncertain significance Single submitter
- AGPAT4 p.Phe341Leu Uncertain significance Single submitter
- AGPAT4 p.Phe346Ser Uncertain significance Single submitter
- AGPAT4 p.Pro302Ser Uncertain significance Single submitter
- AGPAT4 p.Thr359Met Uncertain significance Single submitter
- AGPAT4 p.Trp354Arg Uncertain significance Single submitter
- AGPAT4 p.Val221Gly Uncertain significance Single submitter
- AGPAT4 p.Val344Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- AGPAT4 p.Arg163Trp Uncertain significance Single submitter
- AGPAT4 p.Arg304Gln Uncertain significance Single submitter
- AGPAT4 p.Arg52Ser Uncertain significance Single submitter
- AGPAT4 p.Asp267Asn Uncertain significance Single submitter
- AGPAT4 p.Ile258Phe Uncertain significance Single submitter
- AGPAT4 p.Lys363Asn Uncertain significance Single submitter
- AGPAT4 p.Thr291Met Uncertain significance Single submitter
- AGPAT4 p.Tyr278Phe Uncertain significance Single submitter
- AGPAT4 p.Val20Leu Uncertain significance Single submitter
All AGPAT4 variants
Likely benign 2
- p.Glu269Lys Single submitter
- p.Val16Ile Single submitter
Uncertain significance 31
- p.Ala315Gly Single submitter ⚠
- p.Arg163Trp Single submitter ⚠
- p.Arg199His Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg304Gln Single submitter ⚠
- p.Arg52Ser Single submitter ⚠
- p.Arg80His Single submitter ⚠
- p.Asn245Ser Single submitter ⚠
- p.Asp267Asn Single submitter ⚠
- p.Cys270Arg Single submitter ⚠
- p.Glu140Lys Single submitter ⚠
- p.His250Asp Single submitter ⚠
- p.Ile258Phe Single submitter ⚠
- p.Ile75Thr Single submitter ⚠
- p.Ile91Val Single submitter ⚠
- p.Leu159Met Single submitter ⚠
- p.Lys153Gln Single submitter ⚠
- p.Lys363Asn Single submitter ⚠
- p.Lys43Thr Single submitter ⚠
- p.Met299Val Single submitter ⚠
- p.Phe323Leu Single submitter ⚠
- p.Phe341Leu Single submitter ⚠
- p.Phe346Ser Single submitter ⚠
- p.Pro302Ser Single submitter ⚠
- p.Thr291Met Single submitter ⚠
- p.Thr359Met Single submitter ⚠
- p.Trp354Arg Single submitter ⚠
- p.Tyr278Phe Single submitter ⚠
- p.Val20Leu Single submitter ⚠
- p.Val221Gly Single submitter ⚠
- p.Val344Ile Single submitter ⚠