AGR3 — 25 ClinVar variants
All ClinVar germline AGR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Likely benign · 24 Uncertain significance
Full AGR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGR3 p.Ala130Ser Uncertain significance Single submitter
- AGR3 p.Asn108Ser Uncertain significance Single submitter
- AGR3 p.Asp112His Uncertain significance Single submitter
- AGR3 p.Gln32Arg Uncertain significance Single submitter
- AGR3 p.Gly37Val Uncertain significance Single submitter
- AGR3 p.Gly51Ala Uncertain significance Single submitter
- AGR3 p.Ile22Thr Uncertain significance Single submitter
- AGR3 p.Leu109Ser Uncertain significance Single submitter
- AGR3 p.Met120Val Uncertain significance Single submitter
- AGR3 p.Met90Ile Uncertain significance Single submitter
- AGR3 p.Trp44Cys Uncertain significance Single submitter
- AGR3 p.Tyr141Asn Uncertain significance Single submitter
- AGR3 p.Val122Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- AGR3 p.Ala6Asp Uncertain significance Single submitter
- AGR3 p.Cys10Tyr Uncertain significance Single submitter
- AGR3 p.Gly8Asp Uncertain significance Single submitter
- AGR3 p.Ile162Thr Uncertain significance Single submitter
- AGR3 p.Met97Val Uncertain significance Single submitter
- AGR3 p.Ser18Phe Uncertain significance Single submitter
- AGR3 p.Ser35Pro Uncertain significance Single submitter
- AGR3 p.Thr127Arg Uncertain significance Single submitter
- AGR3 p.Tyr141His Uncertain significance Single submitter
- AGR3 p.Val45Gly Uncertain significance Single submitter
- AGR3 p.Val45Ile Uncertain significance Single submitter
All AGR3 variants
Likely benign 1
- p.Arg146Gln Single submitter
Uncertain significance 24
- p.Ala130Ser Single submitter ⚠
- p.Ala6Asp Single submitter ⚠
- p.Asn108Ser Single submitter ⚠
- p.Asp112His Single submitter ⚠
- p.Cys10Tyr Single submitter ⚠
- p.Gln32Arg Single submitter ⚠
- p.Gly37Val Single submitter ⚠
- p.Gly51Ala Single submitter ⚠
- p.Gly8Asp Single submitter ⚠
- p.Ile162Thr Single submitter ⚠
- p.Ile22Thr Single submitter ⚠
- p.Leu109Ser Single submitter ⚠
- p.Met120Val Single submitter ⚠
- p.Met90Ile Single submitter ⚠
- p.Met97Val Single submitter ⚠
- p.Ser18Phe Single submitter ⚠
- p.Ser35Pro Single submitter ⚠
- p.Thr127Arg Single submitter ⚠
- p.Trp44Cys Single submitter ⚠
- p.Tyr141Asn Single submitter ⚠
- p.Tyr141His Single submitter ⚠
- p.Val122Ile Single submitter ⚠
- p.Val45Gly Single submitter ⚠
- p.Val45Ile Single submitter ⚠