AGRP — 23 ClinVar variants
All ClinVar germline AGRP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
3 Benign · 1 Likely benign · 19 Uncertain significance
Full AGRP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGRP p.Arg120Cys Uncertain significance Single submitter
- AGRP p.Arg33Ser Uncertain significance Single submitter
- AGRP p.Arg48Trp Uncertain significance Single submitter
- AGRP p.Arg85His Uncertain significance Single submitter
- AGRP p.Asp75His Uncertain significance Single submitter
- AGRP p.Cys119Arg Uncertain significance Single submitter
- AGRP p.Gln58His Uncertain significance Single submitter
- AGRP p.Glu60Asp Uncertain significance Single submitter
- AGRP p.Gly96Arg Uncertain significance Single submitter
- AGRP p.Leu38Arg Uncertain significance Single submitter
- AGRP p.Leu42Val Uncertain significance Single submitter
- AGRP p.Leu7Val Uncertain significance Single submitter
- AGRP p.Met126Lys Uncertain significance Single submitter
- AGRP p.Met23Ile Uncertain significance Single submitter
- AGRP p.Pro40Ala Uncertain significance Single submitter
- AGRP p.Val99Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All AGRP variants
Benign 3
- p.Ala67Thr Multiple submitters AGRP-related condition
- p.Arg111= Multiple submitters
- p.Glu41= Multiple submitters
Likely benign 1
- p.Ala5Val Single submitter
Uncertain significance 19
- p.Arg120Cys Single submitter ⚠
- p.Arg131Cys Single submitter ⚠
- p.Arg33Ser Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Arg85His Single submitter ⚠
- p.Asp75His Single submitter ⚠
- p.Cys119Arg Single submitter ⚠
- p.Gln58His Single submitter ⚠
- p.Glu60Asp Single submitter ⚠
- p.Gly96Arg Single submitter ⚠
- p.Leu38Arg Single submitter ⚠
- p.Leu42Val Single submitter ⚠
- p.Leu7Val Single submitter ⚠
- p.Met126Lys Single submitter ⚠
- p.Met23Ile Single submitter ⚠
- p.Pro40Ala Single submitter ⚠
- p.Thr107Met Single submitter ⚠
- p.Val88= Single submitter obesity disorder
- p.Val99Met Single submitter ⚠