AGTR2 — 66 ClinVar variants
All ClinVar germline AGTR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
3 Conflicting · 5 Benign · 1 Benign/Likely benign · 8 Likely benign · 49 Uncertain significance
Full AGTR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 3
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGTR2 p.His237Gln Uncertain significance Multiple submitters
- AGTR2 p.Ala171Val Uncertain significance Single submitter
- AGTR2 p.Ala212Gly Uncertain significance Single submitter
- AGTR2 p.Asn29Ser Uncertain significance Single submitter
- AGTR2 p.Asn310Lys Uncertain significance Single submitter
- AGTR2 p.Asp252Glu Uncertain significance Single submitter
- AGTR2 p.Asp41Asn Uncertain significance Single submitter
- AGTR2 p.Cys195Ser Uncertain significance Single submitter
- AGTR2 p.Glu188Ala Uncertain significance Single submitter
- AGTR2 p.Glu291Lys Uncertain significance Single submitter
- AGTR2 p.Glu30Asp Uncertain significance Single submitter
- AGTR2 p.Gly21Arg Uncertain significance Single submitter
- AGTR2 p.Ile132Ser Uncertain significance Single submitter
- AGTR2 p.Ile187Val Uncertain significance Single submitter
- AGTR2 p.Ile25Asn Uncertain significance Single submitter
- AGTR2 p.Ile293Thr Uncertain significance Single submitter
- AGTR2 p.Ile49Thr Uncertain significance Single submitter
- AGTR2 p.Ile57Thr Uncertain significance Single submitter
- AGTR2 p.Leu239Arg Uncertain significance Single submitter
- AGTR2 p.Lys77Asn Uncertain significance Single submitter
- AGTR2 p.Lys77Glu Uncertain significance Single submitter
- AGTR2 p.Phe55Ile Uncertain significance Single submitter
- AGTR2 p.Pro201Ser Uncertain significance Single submitter
- AGTR2 p.Pro301Leu Uncertain significance Single submitter
- AGTR2 p.Ser105Cys Uncertain significance Single submitter
- AGTR2 p.Ser26Pro Uncertain significance Single submitter
- AGTR2 p.Thr178Ala Uncertain significance Single submitter
- AGTR2 p.Thr241Met Uncertain significance Single submitter
- AGTR2 p.Trp100Arg Uncertain significance Single submitter
- AGTR2 p.Tyr148Cys Uncertain significance Single submitter
- AGTR2 p.Val184Ile Uncertain significance Single submitter
- AGTR2 p.Val23Met Uncertain significance Single submitter
-
AGTR2 p.Cys169Phe
Uncertain significance
No assertion criteria
AGTR2-related disorder
- AGTR2 p.Ile337Val Uncertain significance No assertion criteria
- AGTR2 p.Ile53Phe Uncertain significance No assertion criteria
Predictors split 10
The independent predictors disagree with each other — read with care.
- AGTR2 p.Gly74Asp Uncertain significance Single submitter
- AGTR2 p.His273Asn Uncertain significance Single submitter
- AGTR2 p.Ile222Thr Uncertain significance Single submitter
- AGTR2 p.Phe272Leu Uncertain significance Single submitter
- AGTR2 p.Pro177Ser Uncertain significance Single submitter
- AGTR2 p.Pro271Leu Uncertain significance Single submitter
- AGTR2 p.Ser79Cys Uncertain significance Single submitter
- AGTR2 p.Thr309Asn Uncertain significance Single submitter
- AGTR2 p.Tyr231His Benign Single submitter
- AGTR2 p.Tyr52Asp Uncertain significance Single submitter
All AGTR2 variants
Conflicting classifications of pathogenicity 3
- p.Cys71Ser Single submitter ⚠
- p.Gln37Glu Single submitter ⚠
- p.Arg324Gln No assertion criteria AGTR2-related disorder ⚠
Benign 5
- p.Arg248Lys Multiple submitters
- p.Ile337= Multiple submitters
- p.Leu166= Multiple submitters
- p.Leu126= Single submitter
- p.Tyr231His Single submitter ⚠
Benign/Likely benign 1
- p.Gly21Val Multiple submitters intellectual disability, X-linked 88
Likely benign 8
- p.Phe134fs Multiple submitters
- p.Asp45= Single submitter
- p.Ile222= Single submitter
- p.Ile49Val Single submitter
- p.Leu33= Single submitter
- p.Pro201= Single submitter
- p.Thr338Ala Single submitter
- p.Val313Ile Single submitter
Uncertain significance 49
- p.His237Gln Multiple submitters ⚠
- p.Ala171Val Single submitter ⚠
- p.Ala212Gly Single submitter ⚠
- p.Asn29Ser Single submitter ⚠
- p.Asn310Lys Single submitter ⚠
- p.Asp183Gly Single submitter
- p.Asp252Glu Single submitter ⚠
- p.Asp41Asn Single submitter ⚠
- p.Cys137Ter Single submitter
- p.Cys195Ser Single submitter ⚠
- p.Glu188Ala Single submitter ⚠
- p.Glu291Lys Single submitter ⚠
- p.Glu30Asp Single submitter ⚠
- p.Gly21Arg Single submitter ⚠
- p.Gly74Asp Single submitter ⚠
- p.His273Asn Single submitter ⚠
- p.Ile132Ser Single submitter ⚠
- p.Ile135fs Single submitter
- p.Ile147Asn Single submitter
- p.Ile187Val Single submitter ⚠
- p.Ile222Thr Single submitter ⚠
- p.Ile25Asn Single submitter ⚠
- p.Ile293Thr Single submitter ⚠
- p.Ile49Thr Single submitter ⚠
- p.Ile57Thr Single submitter ⚠
- p.Leu239Arg Single submitter ⚠
- p.Lys77Asn Single submitter ⚠
- p.Lys77Glu Single submitter ⚠
- p.Phe272Leu Single submitter ⚠
- p.Phe55Ile Single submitter ⚠
- p.Pro177Ser Single submitter ⚠
- p.Pro201Ser Single submitter ⚠
- p.Pro271Leu Single submitter ⚠
- p.Pro301Leu Single submitter ⚠
- p.Ser105Cys Single submitter ⚠
- p.Ser26Pro Single submitter ⚠
- p.Ser79Cys Single submitter ⚠
- p.Thr178Ala Single submitter ⚠
- p.Thr241Met Single submitter ⚠
- p.Thr309Asn Single submitter ⚠
- p.Trp100Arg Single submitter ⚠
- p.Tyr148Cys Single submitter ⚠
- p.Tyr52Asp Single submitter ⚠
- p.Val184Ile Single submitter ⚠
- p.Val23Met Single submitter ⚠
- p.Cys169Phe No assertion criteria AGTR2-related disorder ⚠
- p.Ile337Val No assertion criteria ⚠
- p.Ile53Phe No assertion criteria ⚠
- p.Thr250fs No assertion criteria AGTR2-related disorder