AIDA — 22 ClinVar variants
All ClinVar germline AIDA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
22 Uncertain significance
Full AIDA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AIDA p.Asn51Ser Uncertain significance Single submitter
- AIDA p.Asp186Asn Uncertain significance Single submitter
- AIDA p.Cys69Arg Uncertain significance Single submitter
- AIDA p.Glu265Val Uncertain significance Single submitter
- AIDA p.Gly236Asp Uncertain significance Single submitter
- AIDA p.Leu102Val Uncertain significance Single submitter
- AIDA p.Phe148Cys Uncertain significance Single submitter
- AIDA p.Ser147Ala Uncertain significance Single submitter
- AIDA p.Ser24Ala Uncertain significance Single submitter
- AIDA p.Tyr217His Uncertain significance Single submitter
- AIDA p.Val272Ile Uncertain significance Single submitter
- AIDA p.Val4Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- AIDA p.Asp134Tyr Uncertain significance Single submitter
- AIDA p.Glu45Lys Uncertain significance Single submitter
- AIDA p.Gly198Ser Uncertain significance Single submitter
- AIDA p.Ile120Asn Uncertain significance Single submitter
- AIDA p.Ile185Val Uncertain significance Single submitter
- AIDA p.Pro208Ser Uncertain significance Single submitter
- AIDA p.Ser192Thr Uncertain significance Single submitter
- AIDA p.Thr155Ala Uncertain significance Single submitter
- AIDA p.Thr280Ala Uncertain significance Single submitter
- AIDA p.Thr302Ile Uncertain significance Single submitter
All AIDA variants
Uncertain significance 22
- p.Asn51Ser Single submitter ⚠
- p.Asp134Tyr Single submitter ⚠
- p.Asp186Asn Single submitter ⚠
- p.Cys69Arg Single submitter ⚠
- p.Glu265Val Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Gly198Ser Single submitter ⚠
- p.Gly236Asp Single submitter ⚠
- p.Ile120Asn Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Leu102Val Single submitter ⚠
- p.Phe148Cys Single submitter ⚠
- p.Pro208Ser Single submitter ⚠
- p.Ser147Ala Single submitter ⚠
- p.Ser192Thr Single submitter ⚠
- p.Ser24Ala Single submitter ⚠
- p.Thr155Ala Single submitter ⚠
- p.Thr280Ala Single submitter ⚠
- p.Thr302Ile Single submitter ⚠
- p.Tyr217His Single submitter ⚠
- p.Val272Ile Single submitter ⚠
- p.Val4Leu Single submitter ⚠