AIFM2 — 61 ClinVar variants
All ClinVar germline AIFM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
1 Likely benign · 60 Uncertain significance
Full AIFM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AIFM2 p.Ala11Thr Uncertain significance Single submitter
- AIFM2 p.Ala25Thr Uncertain significance Single submitter
- AIFM2 p.Ala27Thr Uncertain significance Single submitter
- AIFM2 p.Ala287Thr Uncertain significance Single submitter
- AIFM2 p.Ala307Val Uncertain significance Single submitter
- AIFM2 p.Ala325Thr Uncertain significance Single submitter
- AIFM2 p.Ala32Ser Uncertain significance Single submitter
- AIFM2 p.Ala99Val Uncertain significance Single submitter
- AIFM2 p.Arg189Gln Uncertain significance Single submitter
- AIFM2 p.Arg198Gln Uncertain significance Single submitter
- AIFM2 p.Arg221Gln Uncertain significance Single submitter
- AIFM2 p.Arg253His Uncertain significance Single submitter
- AIFM2 p.Arg316Gln Uncertain significance Single submitter
- AIFM2 p.Arg348Gln Uncertain significance Single submitter
- AIFM2 p.Arg348Trp Uncertain significance Single submitter
- AIFM2 p.Arg352Gln Uncertain significance Single submitter
- AIFM2 p.Arg357Trp Uncertain significance Single submitter
- AIFM2 p.Arg54Gln Uncertain significance Single submitter
- AIFM2 p.Arg54Pro Uncertain significance Single submitter
- AIFM2 p.Arg78Gln Uncertain significance Single submitter
- AIFM2 p.Asn218Ser Uncertain significance Single submitter
- AIFM2 p.Asn34Lys Uncertain significance Single submitter
- AIFM2 p.Asn76Ile Uncertain significance Single submitter
- AIFM2 p.Asp358Asn Uncertain significance Single submitter
- AIFM2 p.Asp44Val Uncertain significance Single submitter
- AIFM2 p.Gly299Ser Uncertain significance Single submitter
- AIFM2 p.Gly96Ala Uncertain significance Single submitter
- AIFM2 p.Gly96Cys Uncertain significance Single submitter
- AIFM2 p.Leu12Pro Uncertain significance Single submitter
- AIFM2 p.Leu184Ile Uncertain significance Single submitter
- AIFM2 p.Leu353Met Uncertain significance Single submitter
- AIFM2 p.Met350Leu Uncertain significance Single submitter
- AIFM2 p.Met42Thr Uncertain significance Single submitter
- AIFM2 p.Pro317Ala Uncertain significance Single submitter
- AIFM2 p.Ser124Gly Uncertain significance Single submitter
- AIFM2 p.Ser331Pro Uncertain significance Single submitter
- AIFM2 p.Ser342Asn Uncertain significance Single submitter
- AIFM2 p.Ser6Leu Uncertain significance Single submitter
- AIFM2 p.Ser9Leu Uncertain significance Single submitter
- AIFM2 p.Thr291Lys Uncertain significance Single submitter
- AIFM2 p.Thr363Met Uncertain significance Single submitter
- AIFM2 p.Val15Ala Uncertain significance Single submitter
- AIFM2 p.Val170Ala Uncertain significance Single submitter
- AIFM2 p.Val17Met Uncertain significance Single submitter
- AIFM2 p.Val188Ile Uncertain significance Single submitter
- AIFM2 p.Val192Met Uncertain significance Single submitter
- AIFM2 p.Val201Met Uncertain significance Single submitter
- AIFM2 p.Val289Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- AIFM2 p.Ala305Thr Uncertain significance Single submitter
- AIFM2 p.Ala62Thr Uncertain significance Single submitter
- AIFM2 p.Asn49Ser Uncertain significance Single submitter
- AIFM2 p.His271Pro Uncertain significance Single submitter
- AIFM2 p.Lys230Glu Uncertain significance Single submitter
- AIFM2 p.Met157Thr Uncertain significance Single submitter
- AIFM2 p.Pro323Leu Uncertain significance Single submitter
- AIFM2 p.Thr109Met Uncertain significance Single submitter
- AIFM2 p.Val306Leu Uncertain significance Single submitter
- AIFM2 p.Val306Met Uncertain significance Single submitter
All AIFM2 variants
Likely benign 1
- p.Asp75Glu Single submitter
Uncertain significance 60
- p.Ala11Thr Single submitter ⚠
- p.Ala25Thr Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala287Thr Single submitter ⚠
- p.Ala305Thr Single submitter ⚠
- p.Ala307Val Single submitter ⚠
- p.Ala325Thr Single submitter ⚠
- p.Ala32Ser Single submitter ⚠
- p.Ala62Thr Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg189Trp Single submitter
- p.Arg198Gln Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg253His Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg348Trp Single submitter ⚠
- p.Arg352Gln Single submitter ⚠
- p.Arg357Trp Single submitter ⚠
- p.Arg54Gln Single submitter ⚠
- p.Arg54Pro Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Asn218Ser Single submitter ⚠
- p.Asn34Lys Single submitter ⚠
- p.Asn49Ser Single submitter ⚠
- p.Asn76Ile Single submitter ⚠
- p.Asp358Asn Single submitter ⚠
- p.Asp44Val Single submitter ⚠
- p.Gly299Ser Single submitter ⚠
- p.Gly324Asp Single submitter
- p.Gly96Ala Single submitter ⚠
- p.Gly96Cys Single submitter ⚠
- p.His271Pro Single submitter ⚠
- p.Leu12Pro Single submitter ⚠
- p.Leu184Ile Single submitter ⚠
- p.Leu353Met Single submitter ⚠
- p.Lys230Glu Single submitter ⚠
- p.Met157Thr Single submitter ⚠
- p.Met350Leu Single submitter ⚠
- p.Met42Thr Single submitter ⚠
- p.Pro317Ala Single submitter ⚠
- p.Pro323Leu Single submitter ⚠
- p.Ser124Gly Single submitter ⚠
- p.Ser331Pro Single submitter ⚠
- p.Ser342Asn Single submitter ⚠
- p.Ser6Leu Single submitter ⚠
- p.Ser9Leu Single submitter ⚠
- p.Thr109Met Single submitter ⚠
- p.Thr291Lys Single submitter ⚠
- p.Thr363Met Single submitter ⚠
- p.Val15Ala Single submitter ⚠
- p.Val170Ala Single submitter ⚠
- p.Val17Met Single submitter ⚠
- p.Val188Ile Single submitter ⚠
- p.Val192Met Single submitter ⚠
- p.Val201Met Single submitter ⚠
- p.Val289Met Single submitter ⚠
- p.Val306Leu Single submitter ⚠
- p.Val306Met Single submitter ⚠