AIFM3 — 93 ClinVar variants
All ClinVar germline AIFM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
2 Likely benign · 91 Uncertain significance
Full AIFM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AIFM3 p.Thr601Met Uncertain significance Multiple submitters
- AIFM3 p.Ala114Thr Uncertain significance Single submitter
- AIFM3 p.Ala171Val Uncertain significance Single submitter
- AIFM3 p.Ala210Thr Uncertain significance Single submitter
- AIFM3 p.Ala516Thr Uncertain significance Single submitter
- AIFM3 p.Ala559Ser Uncertain significance Single submitter
- AIFM3 p.Arg123Cys Uncertain significance Single submitter
- AIFM3 p.Arg123His Uncertain significance Single submitter
- AIFM3 p.Arg127His Uncertain significance Single submitter
- AIFM3 p.Arg166Gln Uncertain significance Single submitter
- AIFM3 p.Arg214Gln Uncertain significance Single submitter
- AIFM3 p.Arg229Gln Uncertain significance Single submitter
- AIFM3 p.Arg229Gly Uncertain significance Single submitter
- AIFM3 p.Arg24Gln Uncertain significance Single submitter
- AIFM3 p.Arg325His Uncertain significance Single submitter
- AIFM3 p.Arg333His Uncertain significance Single submitter
- AIFM3 p.Arg333Leu Uncertain significance Single submitter
- AIFM3 p.Arg375His Uncertain significance Single submitter
- AIFM3 p.Arg378His Uncertain significance Single submitter
- AIFM3 p.Arg388Gln Uncertain significance Single submitter
- AIFM3 p.Arg38Gln Uncertain significance Single submitter
- AIFM3 p.Arg401Gln Uncertain significance Single submitter
- AIFM3 p.Arg446Gln Uncertain significance Single submitter
- AIFM3 p.Arg479His Uncertain significance Single submitter
- AIFM3 p.Arg47Cys Uncertain significance Single submitter
- AIFM3 p.Arg494Gly Uncertain significance Single submitter
- AIFM3 p.Arg54Leu Uncertain significance Single submitter
- AIFM3 p.Asp596Asn Uncertain significance Single submitter
- AIFM3 p.Cys4Ser Uncertain significance Single submitter
- AIFM3 p.Gln41Arg Uncertain significance Single submitter
- AIFM3 p.Glu28Ala Uncertain significance Single submitter
- AIFM3 p.Glu365Val Uncertain significance Single submitter
- AIFM3 p.Glu69Gly Uncertain significance Single submitter
- AIFM3 p.Gly206Asp Uncertain significance Single submitter
- AIFM3 p.Gly217Val Uncertain significance Single submitter
- AIFM3 p.Gly332Asp Uncertain significance Single submitter
- AIFM3 p.Gly3Val Uncertain significance Single submitter
- AIFM3 p.Gly528Arg Uncertain significance Single submitter
- AIFM3 p.Gly530Ser Uncertain significance Single submitter
- AIFM3 p.Leu105Val Uncertain significance Single submitter
- AIFM3 p.Leu198His Uncertain significance Single submitter
- AIFM3 p.Leu293Pro Uncertain significance Single submitter
- AIFM3 p.Leu304Gln Uncertain significance Single submitter
- AIFM3 p.Lys408Glu Uncertain significance Single submitter
- AIFM3 p.Lys520Glu Uncertain significance Single submitter
- AIFM3 p.Met393Val Uncertain significance Single submitter
- AIFM3 p.Met500Ile Uncertain significance Single submitter
- AIFM3 p.Phe531Leu Uncertain significance Single submitter
- AIFM3 p.Phe588Ser Uncertain significance Single submitter
- AIFM3 p.Pro110Leu Uncertain significance Single submitter
- AIFM3 p.Pro565Thr Uncertain significance Single submitter
- AIFM3 p.Ser239Arg Uncertain significance Single submitter
- AIFM3 p.Ser239Cys Uncertain significance Single submitter
- AIFM3 p.Ser30Leu Uncertain significance Single submitter
- AIFM3 p.Ser32Cys Uncertain significance Single submitter
- AIFM3 p.Thr366Met Uncertain significance Single submitter
- AIFM3 p.Tyr512Cys Uncertain significance Single submitter
- AIFM3 p.Val281Ala Uncertain significance Single submitter
- AIFM3 p.Val281Met Uncertain significance Single submitter
- AIFM3 p.Val326Met Uncertain significance Single submitter
- AIFM3 p.Val410Phe Uncertain significance Single submitter
- AIFM3 p.Val418Met Uncertain significance Single submitter
- AIFM3 p.Val422Ile Uncertain significance Single submitter
- AIFM3 p.Val93Ala Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- AIFM3 p.Ala355Val Uncertain significance Single submitter
- AIFM3 p.Arg125Trp Uncertain significance Single submitter
- AIFM3 p.Arg318Gln Uncertain significance Single submitter
- AIFM3 p.Arg318Trp Uncertain significance Single submitter
- AIFM3 p.Arg84Leu Uncertain significance Single submitter
- AIFM3 p.Asn562Ile Uncertain significance Single submitter
- AIFM3 p.Gly402Asp Uncertain significance Single submitter
- AIFM3 p.Gly447Ser Uncertain significance Single submitter
- AIFM3 p.Gly91Arg Uncertain significance Single submitter
- AIFM3 p.Lys108Glu Uncertain significance Single submitter
- AIFM3 p.Phe368Cys Uncertain significance Single submitter
- AIFM3 p.Pro115Ser Uncertain significance Single submitter
- AIFM3 p.Ser241Pro Uncertain significance Single submitter
- AIFM3 p.Thr195Ile Uncertain significance Single submitter
- AIFM3 p.Tyr527Cys Uncertain significance Single submitter
- AIFM3 p.Val280Ile Uncertain significance Single submitter
All AIFM3 variants
Likely benign 2
- p.Ile317= Single submitter
- p.Val337Ile Single submitter
Uncertain significance 91
- p.Thr601Met Multiple submitters ⚠
- p.Ala104Ser Single submitter
- p.Ala114Thr Single submitter ⚠
- p.Ala171Val Single submitter ⚠
- p.Ala210Thr Single submitter ⚠
- p.Ala355Val Single submitter ⚠
- p.Ala516Thr Single submitter ⚠
- p.Ala559Ser Single submitter ⚠
- p.Arg123Cys Single submitter ⚠
- p.Arg123His Single submitter ⚠
- p.Arg125Trp Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg166Gln Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Arg229Gly Single submitter ⚠
- p.Arg24Gln Single submitter ⚠
- p.Arg318Gln Single submitter ⚠
- p.Arg318Trp Single submitter ⚠
- p.Arg325His Single submitter ⚠
- p.Arg333His Single submitter ⚠
- p.Arg333Leu Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg378His Single submitter ⚠
- p.Arg388Gln Single submitter ⚠
- p.Arg388Trp Single submitter
- p.Arg38Gln Single submitter ⚠
- p.Arg401Gln Single submitter ⚠
- p.Arg446Gln Single submitter ⚠
- p.Arg479His Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg494Gly Single submitter ⚠
- p.Arg54Leu Single submitter ⚠
- p.Arg84Leu Single submitter ⚠
- p.Asn562Ile Single submitter ⚠
- p.Asp596Asn Single submitter ⚠
- p.Cys4Ser Single submitter ⚠
- p.Gln41Arg Single submitter ⚠
- p.Glu28Ala Single submitter ⚠
- p.Glu365Val Single submitter ⚠
- p.Glu69Gly Single submitter ⚠
- p.Gly206Asp Single submitter ⚠
- p.Gly217Val Single submitter ⚠
- p.Gly332Asp Single submitter ⚠
- p.Gly3Val Single submitter ⚠
- p.Gly402Asp Single submitter ⚠
- p.Gly447Ser Single submitter ⚠
- p.Gly528Arg Single submitter ⚠
- p.Gly528Val Single submitter
- p.Gly530Ser Single submitter ⚠
- p.Gly91Arg Single submitter ⚠
- p.Leu105Val Single submitter ⚠
- p.Leu198His Single submitter ⚠
- p.Leu293Pro Single submitter ⚠
- p.Leu304Gln Single submitter ⚠
- p.Leu343Pro Single submitter
- p.Lys108Glu Single submitter ⚠
- p.Lys408Glu Single submitter ⚠
- p.Lys520Glu Single submitter ⚠
- p.Met393Arg Single submitter
- p.Met393Val Single submitter ⚠
- p.Met500Ile Single submitter ⚠
- p.Phe368Cys Single submitter ⚠
- p.Phe531Leu Single submitter ⚠
- p.Phe588Ser Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro115Ser Single submitter ⚠
- p.Pro565Thr Single submitter ⚠
- p.Ser239Arg Single submitter ⚠
- p.Ser239Cys Single submitter ⚠
- p.Ser241Pro Single submitter ⚠
- p.Ser30Leu Single submitter ⚠
- p.Ser32Cys Single submitter ⚠
- p.Thr195Ile Single submitter ⚠
- p.Thr226Met Single submitter
- p.Thr366Met Single submitter ⚠
- p.Tyr512Cys Single submitter ⚠
- p.Tyr527Cys Single submitter ⚠
- p.Val280Ile Single submitter ⚠
- p.Val281Ala Single submitter ⚠
- p.Val281Met Single submitter ⚠
- p.Val314Met Single submitter
- p.Val326Met Single submitter ⚠
- p.Val335Met Single submitter
- p.Val338Met Single submitter
- p.Val410Phe Single submitter ⚠
- p.Val418Met Single submitter ⚠
- p.Val422Ile Single submitter ⚠
- p.Val462Met Single submitter
- p.Val86Met Single submitter
- p.Val93Ala Single submitter ⚠