AJUBA — 57 ClinVar variants
All ClinVar germline AJUBA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Likely benign · 56 Uncertain significance
Full AJUBA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AJUBA p.Ala115Asp Uncertain significance Single submitter
- AJUBA p.Ala117Val Uncertain significance Single submitter
- AJUBA p.Ala193Val Uncertain significance Single submitter
- AJUBA p.Ala209Gly Uncertain significance Single submitter
- AJUBA p.Ala210Thr Uncertain significance Single submitter
- AJUBA p.Ala330Pro Uncertain significance Single submitter
- AJUBA p.Arg110Pro Uncertain significance Single submitter
- AJUBA p.Arg254Gly Uncertain significance Single submitter
- AJUBA p.Arg298His Uncertain significance Single submitter
- AJUBA p.Arg531Gln Uncertain significance Single submitter
- AJUBA p.Asn160Ser Uncertain significance Single submitter
- AJUBA p.Cys476Arg Uncertain significance Single submitter
- AJUBA p.Cys476Ser Uncertain significance Single submitter
- AJUBA p.Gln225His Uncertain significance Single submitter
- AJUBA p.Gln526His Uncertain significance Single submitter
- AJUBA p.Glu206Lys Uncertain significance Single submitter
- AJUBA p.Glu253Asp Uncertain significance Single submitter
- AJUBA p.Gly140Ser Uncertain significance Single submitter
- AJUBA p.Gly154Ser Uncertain significance Single submitter
- AJUBA p.Gly185Asp Uncertain significance Single submitter
- AJUBA p.Gly190Arg Uncertain significance Single submitter
- AJUBA p.Gly190Glu Uncertain significance Single submitter
- AJUBA p.Gly198Arg Uncertain significance Single submitter
- AJUBA p.Gly20Cys Uncertain significance Single submitter
- AJUBA p.Gly245Glu Uncertain significance Single submitter
- AJUBA p.Gly289Asp Uncertain significance Single submitter
- AJUBA p.Gly303Glu Uncertain significance Single submitter
- AJUBA p.Gly43Ala Uncertain significance Single submitter
- AJUBA p.Gly87Ala Uncertain significance Single submitter
- AJUBA p.Leu241Pro Uncertain significance Single submitter
- AJUBA p.Leu41Phe Uncertain significance Single submitter
- AJUBA p.Leu99Phe Uncertain significance Single submitter
- AJUBA p.Pro107Leu Uncertain significance Single submitter
- AJUBA p.Pro192Leu Uncertain significance Single submitter
- AJUBA p.Pro197Ala Uncertain significance Single submitter
- AJUBA p.Pro205Leu Uncertain significance Single submitter
- AJUBA p.Pro259Thr Uncertain significance Single submitter
- AJUBA p.Pro301Thr Uncertain significance Single submitter
- AJUBA p.Pro533Ser Uncertain significance Single submitter
- AJUBA p.Pro93Arg Uncertain significance Single submitter
- AJUBA p.Ser202Tyr Uncertain significance Single submitter
- AJUBA p.Ser22Pro Uncertain significance Single submitter
- AJUBA p.Ser23Gly Uncertain significance Single submitter
- AJUBA p.Ser302Ala Uncertain significance Single submitter
- AJUBA p.Tyr459Cys Uncertain significance Single submitter
- AJUBA p.Tyr537Cys Uncertain significance Single submitter
- AJUBA p.Val288Met Uncertain significance Single submitter
- AJUBA p.Val317Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- AJUBA p.Arg374His Uncertain significance Single submitter
- AJUBA p.Gln416Leu Uncertain significance Single submitter
- AJUBA p.Glu6Val Uncertain significance Single submitter
- AJUBA p.His229Tyr Uncertain significance Single submitter
- AJUBA p.Pro138Arg Uncertain significance Single submitter
- AJUBA p.Ser137Asn Uncertain significance Single submitter
- AJUBA p.Ser141Arg Uncertain significance Single submitter
All AJUBA variants
Likely benign 1
- p.Gly190Ala Single submitter
Uncertain significance 56
- p.Ala115Asp Single submitter ⚠
- p.Ala117Val Single submitter ⚠
- p.Ala193Val Single submitter ⚠
- p.Ala209Gly Single submitter ⚠
- p.Ala210Thr Single submitter ⚠
- p.Ala330Pro Single submitter ⚠
- p.Arg110Pro Single submitter ⚠
- p.Arg254Gly Single submitter ⚠
- p.Arg298His Single submitter ⚠
- p.Arg374His Single submitter ⚠
- p.Arg500Trp Single submitter
- p.Arg531Gln Single submitter ⚠
- p.Asn160Ser Single submitter ⚠
- p.Cys476Arg Single submitter ⚠
- p.Cys476Ser Single submitter ⚠
- p.Gln225His Single submitter ⚠
- p.Gln416Leu Single submitter ⚠
- p.Gln526His Single submitter ⚠
- p.Glu206Lys Single submitter ⚠
- p.Glu253Asp Single submitter ⚠
- p.Glu6Val Single submitter ⚠
- p.Gly140Ser Single submitter ⚠
- p.Gly154Ser Single submitter ⚠
- p.Gly185Asp Single submitter ⚠
- p.Gly190Arg Single submitter ⚠
- p.Gly190Glu Single submitter ⚠
- p.Gly198Arg Single submitter ⚠
- p.Gly20Cys Single submitter ⚠
- p.Gly245Glu Single submitter ⚠
- p.Gly289Asp Single submitter ⚠
- p.Gly303Glu Single submitter ⚠
- p.Gly43Ala Single submitter ⚠
- p.Gly87Ala Single submitter ⚠
- p.His229Tyr Single submitter ⚠
- p.Leu241Pro Single submitter ⚠
- p.Leu41Phe Single submitter ⚠
- p.Leu99Phe Single submitter ⚠
- p.Pro107Leu Single submitter ⚠
- p.Pro138Arg Single submitter ⚠
- p.Pro192Leu Single submitter ⚠
- p.Pro197Ala Single submitter ⚠
- p.Pro205Leu Single submitter ⚠
- p.Pro259Thr Single submitter ⚠
- p.Pro301Thr Single submitter ⚠
- p.Pro533Ser Single submitter ⚠
- p.Pro93Arg Single submitter ⚠
- p.Ser137Asn Single submitter ⚠
- p.Ser141Arg Single submitter ⚠
- p.Ser202Tyr Single submitter ⚠
- p.Ser22Pro Single submitter ⚠
- p.Ser23Gly Single submitter ⚠
- p.Ser302Ala Single submitter ⚠
- p.Tyr459Cys Single submitter ⚠
- p.Tyr537Cys Single submitter ⚠
- p.Val288Met Single submitter ⚠
- p.Val317Ile Single submitter ⚠