AKAP10 — 94 ClinVar variants
All ClinVar germline AKAP10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
1 Conflicting · 3 Benign · 5 Likely benign · 85 Uncertain significance
Full AKAP10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
AKAP10 p.Ile646Val
Conflicting
No assertion criteria
AKAP10-related disorder
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AKAP10 p.Ala196Val Uncertain significance Single submitter
- AKAP10 p.Ala274Thr Uncertain significance Single submitter
- AKAP10 p.Ala274Val Uncertain significance Single submitter
- AKAP10 p.Ala280Thr Uncertain significance Single submitter
- AKAP10 p.Ala326Gly Uncertain significance Single submitter
- AKAP10 p.Ala569Val Uncertain significance Single submitter
- AKAP10 p.Ala61Pro Uncertain significance Single submitter
- AKAP10 p.Arg16Leu Uncertain significance Single submitter
- AKAP10 p.Arg249Cys Uncertain significance Single submitter
- AKAP10 p.Arg254Ser Uncertain significance Single submitter
- AKAP10 p.Arg481His Uncertain significance Single submitter
- AKAP10 p.Arg590Lys Uncertain significance Single submitter
- AKAP10 p.Asn175His Uncertain significance Single submitter
- AKAP10 p.Asn338Ser Uncertain significance Single submitter
- AKAP10 p.Asn474Ser Uncertain significance Single submitter
- AKAP10 p.Asn79Ser Uncertain significance Single submitter
- AKAP10 p.Asp243Asn Uncertain significance Single submitter
- AKAP10 p.Asp297Val Uncertain significance Single submitter
- AKAP10 p.Asp401Asn Uncertain significance Single submitter
- AKAP10 p.Asp534Glu Uncertain significance Single submitter
- AKAP10 p.Gln141Glu Uncertain significance Single submitter
- AKAP10 p.Gln369His Uncertain significance Single submitter
- AKAP10 p.Gln407Lys Uncertain significance Single submitter
- AKAP10 p.Gln617Lys Uncertain significance Single submitter
- AKAP10 p.Gln649Arg Uncertain significance Single submitter
- AKAP10 p.Gln651Arg Uncertain significance Single submitter
- AKAP10 p.Glu266Lys Uncertain significance Single submitter
- AKAP10 p.Gly519Asp Uncertain significance Single submitter
- AKAP10 p.Gly520Arg Uncertain significance Single submitter
- AKAP10 p.Gly528Val Uncertain significance Single submitter
- AKAP10 p.His355Gln Uncertain significance Single submitter
- AKAP10 p.His510Arg Uncertain significance Single submitter
- AKAP10 p.His537Arg Uncertain significance Single submitter
- AKAP10 p.His537Tyr Uncertain significance Single submitter
- AKAP10 p.Ile169Val Uncertain significance Single submitter
- AKAP10 p.Ile223Thr Uncertain significance Single submitter
- AKAP10 p.Ile223Val Uncertain significance Single submitter
- AKAP10 p.Ile565Val Uncertain significance Single submitter
- AKAP10 p.Ile566Val Uncertain significance Single submitter
- AKAP10 p.Ile73Val Uncertain significance Single submitter
- AKAP10 p.Leu237Arg Uncertain significance Single submitter
-
AKAP10 p.Lys284Glu
Uncertain significance
Single submitter
SUDDEN INFANT DEATH SYNDROME
- AKAP10 p.Lys489Glu Uncertain significance Single submitter
- AKAP10 p.Lys658Glu Uncertain significance Single submitter
- AKAP10 p.Met217Val Uncertain significance Single submitter
- AKAP10 p.Met291Arg Uncertain significance Single submitter
- AKAP10 p.Met320Val Uncertain significance Single submitter
- AKAP10 p.Phe216Cys Uncertain significance Single submitter
- AKAP10 p.Pro185His Uncertain significance Single submitter
- AKAP10 p.Pro655Thr Uncertain significance Single submitter
- AKAP10 p.Ser239Pro Uncertain significance Single submitter
- AKAP10 p.Ser275Thr Uncertain significance Single submitter
- AKAP10 p.Ser511Leu Uncertain significance Single submitter
- AKAP10 p.Ser536Thr Uncertain significance Single submitter
- AKAP10 p.Ser544Ala Uncertain significance Single submitter
- AKAP10 p.Ser69Gly Uncertain significance Single submitter
- AKAP10 p.Thr164Ile Uncertain significance Single submitter
- AKAP10 p.Thr90Ala Uncertain significance Single submitter
- AKAP10 p.Trp409Cys Uncertain significance Single submitter
- AKAP10 p.Trp409Leu Uncertain significance Single submitter
- AKAP10 p.Val260Ile Uncertain significance Single submitter
- AKAP10 p.Val341Ile Uncertain significance Single submitter
- AKAP10 p.Val341Phe Uncertain significance Single submitter
- AKAP10 p.Val530Ile Uncertain significance Single submitter
- AKAP10 p.Thr38Ile Uncertain significance No assertion criteria
Predictors split 19
The independent predictors disagree with each other — read with care.
- AKAP10 p.Ala564Val Uncertain significance Single submitter
- AKAP10 p.Ala570Pro Uncertain significance Single submitter
- AKAP10 p.Arg513Gly Uncertain significance Single submitter
- AKAP10 p.Gly333Glu Uncertain significance Single submitter
- AKAP10 p.Gly584Arg Uncertain significance Single submitter
- AKAP10 p.Gly5Arg Uncertain significance Single submitter
- AKAP10 p.Lys304Arg Uncertain significance Single submitter
- AKAP10 p.Lys422Glu Uncertain significance Single submitter
- AKAP10 p.Met351Val Uncertain significance Single submitter
- AKAP10 p.Phe25Ser Uncertain significance Single submitter
- AKAP10 p.Pro12Ser Uncertain significance Single submitter
- AKAP10 p.Ser167Leu Uncertain significance Single submitter
- AKAP10 p.Ser187Phe Uncertain significance Single submitter
- AKAP10 p.Ser231Arg Uncertain significance Single submitter
- AKAP10 p.Ser268Phe Uncertain significance Single submitter
- AKAP10 p.Ser293Asn Uncertain significance Single submitter
- AKAP10 p.Ser417Phe Uncertain significance Single submitter
- AKAP10 p.Ser543Asn Uncertain significance Single submitter
- AKAP10 p.Ser644Gly Uncertain significance Single submitter
All AKAP10 variants
Conflicting classifications of pathogenicity 1
- p.Ile646Val No assertion criteria AKAP10-related disorder ⚠
Benign 3
- c.1641+6G>A No assertion criteria AKAP10-related disorder
- p.Arg249His No assertion criteria AKAP10-related disorder
- p.Ser523Leu No assertion criteria AKAP10-related disorder
Likely benign 5
- p.Gly584= Single submitter
- c.1323-4A>G No assertion criteria AKAP10-related disorder
- p.Arg206= No assertion criteria AKAP10-related disorder
- p.Gln407= No assertion criteria AKAP10-related disorder
- p.Phe340= No assertion criteria AKAP10-related disorder
Uncertain significance 85
- c.1467+5C>A Single submitter cardiac conduction defect
- p.Ala196Val Single submitter ⚠
- p.Ala274Thr Single submitter ⚠
- p.Ala274Val Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala326Gly Single submitter ⚠
- p.Ala564Val Single submitter ⚠
- p.Ala569Val Single submitter ⚠
- p.Ala570Pro Single submitter ⚠
- p.Ala61Pro Single submitter ⚠
- p.Arg16Leu Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg254Ser Single submitter ⚠
- p.Arg481His Single submitter ⚠
- p.Arg513Gly Single submitter ⚠
- p.Arg590Lys Single submitter ⚠
- p.Asn175His Single submitter ⚠
- p.Asn338Ser Single submitter ⚠
- p.Asn474Ser Single submitter ⚠
- p.Asn79Ser Single submitter ⚠
- p.Asp243Asn Single submitter ⚠
- p.Asp297Val Single submitter ⚠
- p.Asp401Asn Single submitter ⚠
- p.Asp534Glu Single submitter ⚠
- p.Gln141Glu Single submitter ⚠
- p.Gln369His Single submitter ⚠
- p.Gln407Lys Single submitter ⚠
- p.Gln617Lys Single submitter ⚠
- p.Gln649Arg Single submitter ⚠
- p.Gln651Arg Single submitter ⚠
- p.Glu266Lys Single submitter ⚠
- p.Gly333Glu Single submitter ⚠
- p.Gly519Asp Single submitter ⚠
- p.Gly520Arg Single submitter ⚠
- p.Gly528Val Single submitter ⚠
- p.Gly584Arg Single submitter ⚠
- p.Gly5Arg Single submitter ⚠
- p.His355Gln Single submitter ⚠
- p.His510Arg Single submitter ⚠
- p.His537Arg Single submitter ⚠
- p.His537Tyr Single submitter ⚠
- p.Ile169Val Single submitter ⚠
- p.Ile223Thr Single submitter ⚠
- p.Ile223Val Single submitter ⚠
- p.Ile565Val Single submitter ⚠
- p.Ile566Val Single submitter ⚠
- p.Ile73Val Single submitter ⚠
- p.Leu237Arg Single submitter ⚠
- p.Lys284Glu Single submitter SUDDEN INFANT DEATH SYNDROME ⚠
- p.Lys304Arg Single submitter ⚠
- p.Lys422Glu Single submitter ⚠
- p.Lys489Glu Single submitter ⚠
- p.Lys658Glu Single submitter ⚠
- p.Met217Val Single submitter ⚠
- p.Met291Arg Single submitter ⚠
- p.Met320Val Single submitter ⚠
- p.Met351Val Single submitter ⚠
- p.Phe216Cys Single submitter ⚠
- p.Phe25Ser Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro185His Single submitter ⚠
- p.Pro655Thr Single submitter ⚠
- p.Ser167Leu Single submitter ⚠
- p.Ser187Phe Single submitter ⚠
- p.Ser231Arg Single submitter ⚠
- p.Ser239Pro Single submitter ⚠
- p.Ser268Phe Single submitter ⚠
- p.Ser275Thr Single submitter ⚠
- p.Ser293Asn Single submitter ⚠
- p.Ser417Phe Single submitter ⚠
- p.Ser511Leu Single submitter ⚠
- p.Ser536Thr Single submitter ⚠
- p.Ser543Asn Single submitter ⚠
- p.Ser544Ala Single submitter ⚠
- p.Ser644Gly Single submitter ⚠
- p.Ser69Gly Single submitter ⚠
- p.Thr164Ile Single submitter ⚠
- p.Thr90Ala Single submitter ⚠
- p.Trp409Cys Single submitter ⚠
- p.Trp409Leu Single submitter ⚠
- p.Val260Ile Single submitter ⚠
- p.Val341Ile Single submitter ⚠
- p.Val341Phe Single submitter ⚠
- p.Val530Ile Single submitter ⚠
- p.Thr38Ile No assertion criteria ⚠