AKR1B10 — 40 ClinVar variants
All ClinVar germline AKR1B10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
6 Likely benign · 34 Uncertain significance
Full AKR1B10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AKR1B10 p.Ala131Thr Uncertain significance Single submitter
- AKR1B10 p.Ala268Glu Uncertain significance Single submitter
- AKR1B10 p.Asn300Asp Uncertain significance Single submitter
- AKR1B10 p.Gln303Glu Uncertain significance Single submitter
- AKR1B10 p.Gly133Ser Uncertain significance Single submitter
- AKR1B10 p.His111Arg Uncertain significance Single submitter
- AKR1B10 p.His201Asn Uncertain significance Single submitter
- AKR1B10 p.Thr20Pro Uncertain significance Single submitter
- AKR1B10 p.Val107Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- AKR1B10 p.Ala144Val Uncertain significance Single submitter
- AKR1B10 p.Ala245Thr Likely benign Single submitter
- AKR1B10 p.Ala245Val Uncertain significance Single submitter
- AKR1B10 p.Arg251His Uncertain significance Single submitter
- AKR1B10 p.Asp99Tyr Uncertain significance Single submitter
- AKR1B10 p.Gln166His Uncertain significance Single submitter
- AKR1B10 p.Gln275Arg Uncertain significance Single submitter
- AKR1B10 p.Glu168Lys Uncertain significance Single submitter
- AKR1B10 p.Glu194Asp Uncertain significance Single submitter
- AKR1B10 p.His253Arg Uncertain significance Single submitter
- AKR1B10 p.Lys125Arg Uncertain significance Single submitter
- AKR1B10 p.Lys128Asn Uncertain significance Single submitter
- AKR1B10 p.Lys235Glu Uncertain significance Single submitter
- AKR1B10 p.Lys243Asn Uncertain significance Single submitter
- AKR1B10 p.Lys263Asn Uncertain significance Single submitter
- AKR1B10 p.Lys95Thr Uncertain significance Single submitter
- AKR1B10 p.Phe252Leu Uncertain significance Single submitter
- AKR1B10 p.Phe312Tyr Uncertain significance Single submitter
- AKR1B10 p.Pro24Ser Uncertain significance Single submitter
- AKR1B10 p.Ser282Asn Uncertain significance Single submitter
- AKR1B10 p.Thr137Met Uncertain significance Single submitter
- AKR1B10 p.Thr244Asn Uncertain significance Single submitter
- AKR1B10 p.Val248Ile Uncertain significance Single submitter
- AKR1B10 p.Val260Phe Uncertain significance Single submitter
- AKR1B10 p.Val28Leu Uncertain significance Single submitter
- AKR1B10 p.Val76Ile Uncertain significance Single submitter
All AKR1B10 variants
Likely benign 6
- p.Ala245Thr Single submitter ⚠
- p.Glu224= Single submitter
- p.Leu79= Single submitter
- p.Lys222= Single submitter
- p.Pro223= Single submitter
- p.Ser163Asn Single submitter
Uncertain significance 34
- p.Ala131Thr Single submitter ⚠
- p.Ala144Val Single submitter ⚠
- p.Ala245Val Single submitter ⚠
- p.Ala268Glu Single submitter ⚠
- p.Arg251His Single submitter ⚠
- p.Asn300Asp Single submitter ⚠
- p.Asp99Tyr Single submitter ⚠
- p.Gln166His Single submitter ⚠
- p.Gln275Arg Single submitter ⚠
- p.Gln303Glu Single submitter ⚠
- p.Glu168Lys Single submitter ⚠
- p.Glu194Asp Single submitter ⚠
- p.Gly133Ser Single submitter ⚠
- p.His111Arg Single submitter ⚠
- p.His201Asn Single submitter ⚠
- p.His253Arg Single submitter ⚠
- p.Lys125Arg Single submitter ⚠
- p.Lys128Asn Single submitter ⚠
- p.Lys235Glu Single submitter ⚠
- p.Lys243Asn Single submitter ⚠
- p.Lys263Asn Single submitter ⚠
- p.Lys95Thr Single submitter ⚠
- p.Phe252Leu Single submitter ⚠
- p.Phe312Tyr Single submitter ⚠
- p.Pro24Ser Single submitter ⚠
- p.Ser282Asn Single submitter ⚠
- p.Thr137Met Single submitter ⚠
- p.Thr20Pro Single submitter ⚠
- p.Thr244Asn Single submitter ⚠
- p.Val107Ile Single submitter ⚠
- p.Val248Ile Single submitter ⚠
- p.Val260Phe Single submitter ⚠
- p.Val28Leu Single submitter ⚠
- p.Val76Ile Single submitter ⚠