AKR1C3 — 69 ClinVar variants
All ClinVar germline AKR1C3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
4 Benign · 4 Likely benign · 61 Uncertain significance
Full AKR1C3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AKR1C3 p.Ala245Thr Uncertain significance Single submitter
- AKR1C3 p.Ala34Val Uncertain significance Single submitter
- AKR1C3 p.Ala41Thr Uncertain significance Single submitter
- AKR1C3 p.Arg250Gln Uncertain significance Single submitter
- AKR1C3 p.Arg96Gln Uncertain significance Single submitter
- AKR1C3 p.Asn167Asp Uncertain significance Single submitter
- AKR1C3 p.Asn167Lys Uncertain significance Single submitter
- AKR1C3 p.Glu28Gln Uncertain significance Single submitter
- AKR1C3 p.His117Arg Uncertain significance Single submitter
- AKR1C3 p.His5Asp Uncertain significance Single submitter
- AKR1C3 p.Ile211Ser Uncertain significance Single submitter
- AKR1C3 p.Ile42Thr Uncertain significance Single submitter
- AKR1C3 p.Ile65Ser Uncertain significance Single submitter
- AKR1C3 p.Leu108Ser Uncertain significance Single submitter
- AKR1C3 p.Phe80Leu Uncertain significance Single submitter
- AKR1C3 p.Pro186Ser Uncertain significance Single submitter
- AKR1C3 p.Ser129Leu Uncertain significance Single submitter
- AKR1C3 p.Ser271Asn Uncertain significance Single submitter
- AKR1C3 p.Val283Ile Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- AKR1C3 p.Pro195Leu Likely benign Multiple submitters
- AKR1C3 p.Ala150Ser Uncertain significance Single submitter
- AKR1C3 p.Ala150Val Uncertain significance Single submitter
- AKR1C3 p.Ala253Val Uncertain significance Single submitter
- AKR1C3 p.Ala269Gly Uncertain significance Single submitter
- AKR1C3 p.Arg171Met Uncertain significance Single submitter
- AKR1C3 p.Arg250Gly Uncertain significance Single submitter
- AKR1C3 p.Arg258His Uncertain significance Single submitter
- AKR1C3 p.Arg276Cys Uncertain significance Single submitter
- AKR1C3 p.Arg276Leu Uncertain significance Single submitter
- AKR1C3 p.Arg301Thr Uncertain significance Single submitter
- AKR1C3 p.Arg47Cys Uncertain significance Single submitter
- AKR1C3 p.Asn198Lys Uncertain significance Single submitter
- AKR1C3 p.Asn273Ser Uncertain significance Single submitter
- AKR1C3 p.Asp229Gly Uncertain significance Single submitter
- AKR1C3 p.Asp300His Uncertain significance Single submitter
- AKR1C3 p.Cys145Tyr Benign Single submitter
- AKR1C3 p.Gln107His Uncertain significance Single submitter
- AKR1C3 p.Gln190Glu Uncertain significance Single submitter
- AKR1C3 p.Gln282Pro Uncertain significance Single submitter
- AKR1C3 p.Glu285Gln Uncertain significance Single submitter
- AKR1C3 p.Glu291Gln Uncertain significance Single submitter
- AKR1C3 p.His90Arg Uncertain significance Single submitter
- AKR1C3 p.Ile277Val Uncertain significance Single submitter
- AKR1C3 p.Leu128Pro Uncertain significance Single submitter
- AKR1C3 p.Leu244Trp Uncertain significance Single submitter
- AKR1C3 p.Lys123Glu Uncertain significance Single submitter
- AKR1C3 p.Lys201Glu Uncertain significance Single submitter
- AKR1C3 p.Lys209Glu Uncertain significance Single submitter
- AKR1C3 p.Met151Ile Uncertain significance Single submitter
- AKR1C3 p.Pro124Leu Uncertain significance Single submitter
- AKR1C3 p.Pro26Ser Uncertain significance Single submitter
- AKR1C3 p.Ser162Phe Uncertain significance Single submitter
- AKR1C3 p.Ser310Cys Uncertain significance Single submitter
- AKR1C3 p.Thr82Ala Uncertain significance Single submitter
- AKR1C3 p.Trp227Cys Uncertain significance Single submitter
- AKR1C3 p.Tyr319Asn Uncertain significance Single submitter
- AKR1C3 p.Tyr319Ser Uncertain significance Single submitter
- AKR1C3 p.Val142Gly Uncertain significance Single submitter
- AKR1C3 p.Val267Leu Uncertain significance Single submitter
- AKR1C3 p.Val61Leu Uncertain significance Single submitter
- AKR1C3 p.Val74Ala Uncertain significance Single submitter
- AKR1C3 p.Val8Leu Uncertain significance Single submitter
-
AKR1C3 p.Lys9Asn
Uncertain significance
No assertion criteria
prostate cancer
All AKR1C3 variants
Benign 4
- p.Arg66Gln Multiple submitters
- p.Lys153= Multiple submitters
- p.Arg199Gln Single submitter
- p.Cys145Tyr Single submitter ⚠
Likely benign 4
- p.Pro195Leu Multiple submitters ⚠
- p.Gln190Ter Single submitter
- p.Met120Val Single submitter
- p.Met16Ile Single submitter
Uncertain significance 61
- p.Ala150Ser Single submitter ⚠
- p.Ala150Val Single submitter ⚠
- p.Ala245Thr Single submitter ⚠
- p.Ala253Val Single submitter ⚠
- p.Ala269Gly Single submitter ⚠
- p.Ala34Val Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Arg171Met Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Arg250Gly Single submitter ⚠
- p.Arg258His Single submitter ⚠
- p.Arg276Cys Single submitter ⚠
- p.Arg276Leu Single submitter ⚠
- p.Arg301Thr Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Asn167Asp Single submitter ⚠
- p.Asn167Lys Single submitter ⚠
- p.Asn198Lys Single submitter ⚠
- p.Asn273Ser Single submitter ⚠
- p.Asp229Gly Single submitter ⚠
- p.Asp300His Single submitter ⚠
- p.Gln107His Single submitter ⚠
- p.Gln190Glu Single submitter ⚠
- p.Gln282Pro Single submitter ⚠
- p.Glu285Gln Single submitter ⚠
- p.Glu28Gln Single submitter ⚠
- p.Glu291Gln Single submitter ⚠
- p.His117Arg Single submitter ⚠
- p.His5Asp Single submitter ⚠
- p.His90Arg Single submitter ⚠
- p.Ile211Ser Single submitter ⚠
- p.Ile277Val Single submitter ⚠
- p.Ile42Thr Single submitter ⚠
- p.Ile65Ser Single submitter ⚠
- p.Leu108Ser Single submitter ⚠
- p.Leu128Pro Single submitter ⚠
- p.Leu244Trp Single submitter ⚠
- p.Lys123Glu Single submitter ⚠
- p.Lys201Glu Single submitter ⚠
- p.Lys209Glu Single submitter ⚠
- p.Met151Ile Single submitter ⚠
- p.Phe80Leu Single submitter ⚠
- p.Pro124Leu Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Pro26Ser Single submitter ⚠
- p.Ser129Leu Single submitter ⚠
- p.Ser162Phe Single submitter ⚠
- p.Ser271Asn Single submitter ⚠
- p.Ser310Cys Single submitter ⚠
- p.Thr82Ala Single submitter ⚠
- p.Trp227Cys Single submitter ⚠
- p.Tyr319Asn Single submitter ⚠
- p.Tyr319Ser Single submitter ⚠
- p.Val142Gly Single submitter ⚠
- p.Val267Leu Single submitter ⚠
- p.Val283Ile Single submitter ⚠
- p.Val61Leu Single submitter ⚠
- p.Val74Ala Single submitter ⚠
- p.Val8Leu Single submitter ⚠
- p.Lys9Asn No assertion criteria prostate cancer ⚠