ALCAM — 83 ClinVar variants
All ClinVar germline ALCAM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
7 Benign · 2 Benign/Likely benign · 7 Likely benign · 67 Uncertain significance
Full ALCAM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALCAM p.Ala19Thr Uncertain significance Single submitter
- ALCAM p.Ala349Thr Uncertain significance Single submitter
- ALCAM p.Arg10Cys Uncertain significance Single submitter
- ALCAM p.Asp119Asn Uncertain significance Single submitter
- ALCAM p.Asp156Glu Uncertain significance Single submitter
- ALCAM p.Asp165Val Uncertain significance Single submitter
- ALCAM p.Asp386Val Uncertain significance Single submitter
- ALCAM p.Asp509Asn Uncertain significance Single submitter
- ALCAM p.Asp82Asn Uncertain significance Single submitter
- ALCAM p.Gln248His Uncertain significance Single submitter
- ALCAM p.Gln252Glu Uncertain significance Single submitter
- ALCAM p.Glu513Lys Uncertain significance Single submitter
- ALCAM p.Glu94Asp Uncertain significance Single submitter
- ALCAM p.Ile327Leu Uncertain significance Single submitter
- ALCAM p.Ile356Val Uncertain significance Single submitter
- ALCAM p.Ile433Val Uncertain significance Single submitter
- ALCAM p.Ile505Val Uncertain significance Single submitter
- ALCAM p.Ile529Thr Uncertain significance Single submitter
- ALCAM p.Leu90Ser Uncertain significance Single submitter
- ALCAM p.Lys190Arg Uncertain significance Single submitter
- ALCAM p.Lys422Arg Uncertain significance Single submitter
- ALCAM p.Met201Ile Uncertain significance Single submitter
- ALCAM p.Met321Ile Uncertain significance Single submitter
- ALCAM p.Met321Thr Uncertain significance Single submitter
- ALCAM p.Met551Val Uncertain significance Single submitter
- ALCAM p.Met568Thr Uncertain significance Single submitter
- ALCAM p.Phe145Val Uncertain significance Single submitter
- ALCAM p.Phe188Leu Uncertain significance Single submitter
- ALCAM p.Pro351Ser Uncertain significance Single submitter
- ALCAM p.Pro42Leu Uncertain significance Single submitter
- ALCAM p.Ser221Thr Uncertain significance Single submitter
- ALCAM p.Ser452Asn Uncertain significance Single submitter
- ALCAM p.Ser77Gly Uncertain significance Single submitter
- ALCAM p.Ser8Phe Uncertain significance Single submitter
- ALCAM p.Thr219Ser Uncertain significance Single submitter
- ALCAM p.Thr494Ala Uncertain significance Single submitter
- ALCAM p.Val140Ile Uncertain significance Single submitter
- ALCAM p.Val342Leu Uncertain significance Single submitter
- ALCAM p.Val47Ala Uncertain significance Single submitter
- ALCAM p.Val47Ile Uncertain significance Single submitter
- ALCAM p.Val533Ile Uncertain significance Single submitter
- ALCAM p.Val546Ile Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- ALCAM p.Pro84Leu Benign Multiple submitters
- ALCAM p.Thr301Met Benign Multiple submitters
- ALCAM p.Ala19Pro Uncertain significance Single submitter
- ALCAM p.Asp302His Uncertain significance Single submitter
- ALCAM p.Asp82Val Uncertain significance Single submitter
- ALCAM p.Gln345Glu Uncertain significance Single submitter
- ALCAM p.Glu118Lys Uncertain significance Single submitter
- ALCAM p.Glu160Asp Uncertain significance Single submitter
- ALCAM p.Ile100Val Uncertain significance Single submitter
- ALCAM p.Ile260Val Uncertain significance Single submitter
- ALCAM p.Ile292Arg Uncertain significance Single submitter
- ALCAM p.Ile68Val Uncertain significance Single submitter
- ALCAM p.Leu98Val Uncertain significance Single submitter
- ALCAM p.Lys129Gln Uncertain significance Single submitter
- ALCAM p.Lys189Glu Uncertain significance Single submitter
- ALCAM p.Phe122Leu Uncertain significance Single submitter
- ALCAM p.Phe145Leu Uncertain significance Single submitter
- ALCAM p.Pro194Ser Uncertain significance Single submitter
- ALCAM p.Pro42Ser Uncertain significance Single submitter
- ALCAM p.Ser294Ile Uncertain significance Single submitter
- ALCAM p.Thr169Ala Uncertain significance Single submitter
- ALCAM p.Thr363Asn Uncertain significance Single submitter
- ALCAM p.Val121Met Uncertain significance Single submitter
- ALCAM p.Val253Met Uncertain significance Single submitter
- ALCAM p.Val342Ala Uncertain significance Single submitter
- ALCAM p.Val342Met Uncertain significance Single submitter
- ALCAM p.Val534Ala Uncertain significance Single submitter
All ALCAM variants
Benign 7
- p.Asp81= Multiple submitters
- p.Leu254= Multiple submitters
- p.Pro84Leu Multiple submitters ⚠
- p.Thr301Met Multiple submitters ⚠
- p.Tyr224= Multiple submitters
- c.74-5dup Single submitter
- p.Arg360Ser Single submitter
Likely benign 7
- p.Ala183Val Single submitter
- p.Asp82= Single submitter
- p.His178Gln Single submitter
- p.Lys555= Single submitter
- p.Thr20Ala Single submitter
- p.Thr301= Single submitter
- p.Val31= Single submitter
Uncertain significance 67
- p.Ala19Pro Single submitter ⚠
- p.Ala19Thr Single submitter ⚠
- p.Ala349Thr Single submitter ⚠
- p.Arg10Cys Single submitter ⚠
- p.Asp119Asn Single submitter ⚠
- p.Asp156Glu Single submitter ⚠
- p.Asp165Val Single submitter ⚠
- p.Asp302His Single submitter ⚠
- p.Asp386Val Single submitter ⚠
- p.Asp509Asn Single submitter ⚠
- p.Asp82Asn Single submitter ⚠
- p.Asp82Val Single submitter ⚠
- p.Gln248His Single submitter ⚠
- p.Gln252Glu Single submitter ⚠
- p.Gln345Glu Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu160Asp Single submitter ⚠
- p.Glu513Lys Single submitter ⚠
- p.Glu94Asp Single submitter ⚠
- p.Ile100Val Single submitter ⚠
- p.Ile260Val Single submitter ⚠
- p.Ile292Arg Single submitter ⚠
- p.Ile327Leu Single submitter ⚠
- p.Ile356Val Single submitter ⚠
- p.Ile433Val Single submitter ⚠
- p.Ile505Val Single submitter ⚠
- p.Ile529Thr Single submitter ⚠
- p.Ile68Val Single submitter ⚠
- p.Leu90Ser Single submitter ⚠
- p.Leu98Val Single submitter ⚠
- p.Lys129Gln Single submitter ⚠
- p.Lys189Glu Single submitter ⚠
- p.Lys190Arg Single submitter ⚠
- p.Lys422Arg Single submitter ⚠
- p.Met201Ile Single submitter ⚠
- p.Met321Ile Single submitter ⚠
- p.Met321Thr Single submitter ⚠
- p.Met551Val Single submitter ⚠
- p.Met568Thr Single submitter ⚠
- p.Phe122Leu Single submitter ⚠
- p.Phe145Leu Single submitter ⚠
- p.Phe145Val Single submitter ⚠
- p.Phe188Leu Single submitter ⚠
- p.Pro194Ser Single submitter ⚠
- p.Pro351Ser Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Ser221Thr Single submitter ⚠
- p.Ser294Ile Single submitter ⚠
- p.Ser452Asn Single submitter ⚠
- p.Ser77Gly Single submitter ⚠
- p.Ser8Phe Single submitter ⚠
- p.Thr169Ala Single submitter ⚠
- p.Thr219Ser Single submitter ⚠
- p.Thr363Asn Single submitter ⚠
- p.Thr494Ala Single submitter ⚠
- p.Val121Met Single submitter ⚠
- p.Val140Ile Single submitter ⚠
- p.Val253Met Single submitter ⚠
- p.Val342Ala Single submitter ⚠
- p.Val342Leu Single submitter ⚠
- p.Val342Met Single submitter ⚠
- p.Val47Ala Single submitter ⚠
- p.Val47Ile Single submitter ⚠
- p.Val533Ile Single submitter ⚠
- p.Val534Ala Single submitter ⚠
- p.Val546Ile Single submitter ⚠