ALDH3B1 — 17 ClinVar variants
All ClinVar germline ALDH3B1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
5 Likely benign · 12 Uncertain significance
Full ALDH3B1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 10
The independent predictors disagree with each other — read with care.
- ALDH3B1 p.Ala17Val Uncertain significance Single submitter
- ALDH3B1 p.Ala201Gly Uncertain significance Single submitter
- ALDH3B1 p.Ala240Val Uncertain significance Single submitter
- ALDH3B1 p.Ala47Thr Uncertain significance Single submitter
- ALDH3B1 p.Arg442Cys Uncertain significance Single submitter
- ALDH3B1 p.Arg9Trp Uncertain significance Single submitter
- ALDH3B1 p.Glu328Gln Uncertain significance Single submitter
- ALDH3B1 p.His394Tyr Uncertain significance Single submitter
- ALDH3B1 p.Thr227Ser Uncertain significance Single submitter
- ALDH3B1 p.Thr7Met Uncertain significance Single submitter
All ALDH3B1 variants
Likely benign 5
Uncertain significance 12
- p.Ala17Val Single submitter ⚠
- p.Ala201Gly Single submitter ⚠
- p.Ala240Val Single submitter ⚠
- p.Ala47Thr Single submitter ⚠
- p.Arg442Cys Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Glu328Gln Single submitter ⚠
- p.Gly212Glu Single submitter ⚠
- p.His394Tyr Single submitter ⚠
- p.Thr227Ile Single submitter ⚠
- p.Thr227Ser Single submitter ⚠
- p.Thr7Met Single submitter ⚠