ALDH3B2 — 41 ClinVar variants
All ClinVar germline ALDH3B2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Likely benign · 39 Uncertain significance
Full ALDH3B2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALDH3B2 p.Ala152Thr Uncertain significance Single submitter
- ALDH3B2 p.Ala285Thr Uncertain significance Single submitter
- ALDH3B2 p.Arg233His Uncertain significance Single submitter
- ALDH3B2 p.Arg374His Uncertain significance Single submitter
- ALDH3B2 p.Asp167Ala Uncertain significance Single submitter
- ALDH3B2 p.Asp167Glu Uncertain significance Single submitter
- ALDH3B2 p.Asp232Asn Uncertain significance Single submitter
- ALDH3B2 p.Asp367Asn Uncertain significance Single submitter
- ALDH3B2 p.Gln295His Uncertain significance Single submitter
- ALDH3B2 p.Glu230Lys Uncertain significance Single submitter
- ALDH3B2 p.Glu245Gly Uncertain significance Single submitter
- ALDH3B2 p.Gly353Ser Uncertain significance Single submitter
- ALDH3B2 p.His98Leu Uncertain significance Single submitter
- ALDH3B2 p.Ile204Phe Uncertain significance Single submitter
- ALDH3B2 p.Pro237Ser Uncertain significance Single submitter
- ALDH3B2 p.Ser290Arg Uncertain significance Single submitter
- ALDH3B2 p.Ser80Arg Uncertain significance Single submitter
- ALDH3B2 p.Thr366Asn Uncertain significance Single submitter
- ALDH3B2 p.Thr383Ile Uncertain significance Single submitter
- ALDH3B2 p.Thr65Ala Uncertain significance Single submitter
- ALDH3B2 p.Trp33Cys Uncertain significance Single submitter
- ALDH3B2 p.Val164Met Uncertain significance Single submitter
- ALDH3B2 p.Val267Ala Uncertain significance Single submitter
- ALDH3B2 p.Val267Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- ALDH3B2 p.Ala270Thr Uncertain significance Single submitter
- ALDH3B2 p.Ala47Thr Uncertain significance Single submitter
- ALDH3B2 p.Ala49Thr Uncertain significance Single submitter
- ALDH3B2 p.Arg150His Uncertain significance Single submitter
- ALDH3B2 p.Arg345His Uncertain significance Single submitter
- ALDH3B2 p.Arg6Trp Uncertain significance Single submitter
- ALDH3B2 p.Gly303Ser Uncertain significance Single submitter
- ALDH3B2 p.Gly88Arg Uncertain significance Single submitter
- ALDH3B2 p.Leu281Val Uncertain significance Single submitter
- ALDH3B2 p.Phe190Ile Uncertain significance Single submitter
- ALDH3B2 p.Pro23Thr Uncertain significance Single submitter
- ALDH3B2 p.Pro58Leu Uncertain significance Single submitter
- ALDH3B2 p.Tyr365Ser Uncertain significance Single submitter
- ALDH3B2 p.Val138Met Uncertain significance Single submitter
- ALDH3B2 p.Val54Met Uncertain significance Single submitter
All ALDH3B2 variants
Likely benign 2
- p.Gln277Arg Single submitter
- p.Val169Ile Single submitter
Uncertain significance 39
- p.Ala152Thr Single submitter ⚠
- p.Ala270Thr Single submitter ⚠
- p.Ala285Thr Single submitter ⚠
- p.Ala47Thr Single submitter ⚠
- p.Ala49Thr Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg233His Single submitter ⚠
- p.Arg345His Single submitter ⚠
- p.Arg374His Single submitter ⚠
- p.Arg6Trp Single submitter ⚠
- p.Asp167Ala Single submitter ⚠
- p.Asp167Glu Single submitter ⚠
- p.Asp232Asn Single submitter ⚠
- p.Asp367Asn Single submitter ⚠
- p.Gln295His Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Glu245Gly Single submitter ⚠
- p.Gly303Ser Single submitter ⚠
- p.Gly353Ser Single submitter ⚠
- p.Gly88Arg Single submitter ⚠
- p.His98Leu Single submitter ⚠
- p.Ile204Phe Single submitter ⚠
- p.Leu281Val Single submitter ⚠
- p.Phe190Ile Single submitter ⚠
- p.Pro237Ser Single submitter ⚠
- p.Pro23Thr Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Ser290Arg Single submitter ⚠
- p.Ser80Arg Single submitter ⚠
- p.Thr366Asn Single submitter ⚠
- p.Thr383Ile Single submitter ⚠
- p.Thr65Ala Single submitter ⚠
- p.Trp33Cys Single submitter ⚠
- p.Tyr365Ser Single submitter ⚠
- p.Val138Met Single submitter ⚠
- p.Val164Met Single submitter ⚠
- p.Val267Ala Single submitter ⚠
- p.Val267Met Single submitter ⚠
- p.Val54Met Single submitter ⚠