ALG1L2 — 60 ClinVar variants
All ClinVar germline ALG1L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
10 Likely benign · 50 Uncertain significance
Full ALG1L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALG1L2 p.Ala173Thr Uncertain significance Single submitter
- ALG1L2 p.Ala210Val Uncertain significance Single submitter
- ALG1L2 p.Ala43Val Uncertain significance Single submitter
- ALG1L2 p.Ala56Ser Uncertain significance Single submitter
- ALG1L2 p.Ala75Gly Uncertain significance Single submitter
- ALG1L2 p.Arg115His Uncertain significance Single submitter
- ALG1L2 p.Arg191Cys Uncertain significance Single submitter
- ALG1L2 p.Arg191His Uncertain significance Single submitter
- ALG1L2 p.Arg69Cys Uncertain significance Single submitter
- ALG1L2 p.Arg73Gly Uncertain significance Single submitter
- ALG1L2 p.Asn95Lys Uncertain significance Single submitter
- ALG1L2 p.Asp13Asn Uncertain significance Single submitter
- ALG1L2 p.Asp165Asn Uncertain significance Single submitter
- ALG1L2 p.Glu133Ala Uncertain significance Single submitter
- ALG1L2 p.Glu133Gln Uncertain significance Single submitter
- ALG1L2 p.Glu188Asp Uncertain significance Single submitter
- ALG1L2 p.Glu198Gln Uncertain significance Single submitter
- ALG1L2 p.Glu72Lys Uncertain significance Single submitter
- ALG1L2 p.Gly142Ala Uncertain significance Single submitter
- ALG1L2 p.Gly65Arg Uncertain significance Single submitter
- ALG1L2 p.His124Tyr Uncertain significance Single submitter
- ALG1L2 p.His182Tyr Uncertain significance Single submitter
- ALG1L2 p.His71Gln Uncertain significance Single submitter
- ALG1L2 p.Ile117Leu Uncertain significance Single submitter
- ALG1L2 p.Leu150Val Uncertain significance Single submitter
- ALG1L2 p.Leu192Pro Uncertain significance Single submitter
- ALG1L2 p.Leu99Pro Uncertain significance Single submitter
- ALG1L2 p.Lys162Thr Uncertain significance Single submitter
- ALG1L2 p.Met166Val Uncertain significance Single submitter
- ALG1L2 p.Phe18Ser Uncertain significance Single submitter
- ALG1L2 p.Pro138Ala Uncertain significance Single submitter
- ALG1L2 p.Pro138His Uncertain significance Single submitter
- ALG1L2 p.Pro97Ser Uncertain significance Single submitter
- ALG1L2 p.Ser55Leu Uncertain significance Single submitter
- ALG1L2 p.Ser79Arg Uncertain significance Single submitter
- ALG1L2 p.Thr37Met Uncertain significance Single submitter
- ALG1L2 p.Thr68Met Uncertain significance Single submitter
- ALG1L2 p.Thr84Ala Uncertain significance Single submitter
- ALG1L2 p.Val100Ile Uncertain significance Single submitter
- ALG1L2 p.Val11Ile Uncertain significance Single submitter
- ALG1L2 p.Val127Ala Uncertain significance Single submitter
- ALG1L2 p.Val176Met Uncertain significance Single submitter
- ALG1L2 p.Val78Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ALG1L2 p.Arg54Trp Uncertain significance Single submitter
- ALG1L2 p.Arg60Trp Likely benign Single submitter
- ALG1L2 p.Pro108Thr Uncertain significance Single submitter
- ALG1L2 p.Thr152Met Uncertain significance Single submitter
- ALG1L2 p.Thr58Met Uncertain significance Single submitter
- ALG1L2 p.Tyr112Cys Uncertain significance Single submitter
All ALG1L2 variants
Likely benign 10
- p.Ala22Thr Single submitter
- p.Arg168Gly Single submitter
- p.Arg29Trp Single submitter
- p.Arg44Cys Single submitter
- p.Arg60Trp Single submitter ⚠
- p.Arg69His Single submitter
- p.Asp147Gly Single submitter
- p.Asp151His Single submitter
- p.Gln94His Single submitter
- p.Thr4= Single submitter
Uncertain significance 50
- p.Ala173Thr Single submitter ⚠
- p.Ala210Val Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala56Ser Single submitter ⚠
- p.Ala75Gly Single submitter ⚠
- p.Arg115His Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg191His Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg73Gly Single submitter ⚠
- p.Asn95Lys Single submitter ⚠
- p.Asp13Asn Single submitter ⚠
- p.Asp165Asn Single submitter ⚠
- p.Cys101Tyr Single submitter
- p.Glu133Ala Single submitter ⚠
- p.Glu133Gln Single submitter ⚠
- p.Glu183Asp Single submitter
- p.Glu188Asp Single submitter ⚠
- p.Glu198Gln Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Gly142Ala Single submitter ⚠
- p.Gly65Arg Single submitter ⚠
- p.His124Tyr Single submitter ⚠
- p.His182Tyr Single submitter ⚠
- p.His71Gln Single submitter ⚠
- p.Ile117Leu Single submitter ⚠
- p.Leu150Val Single submitter ⚠
- p.Leu192Pro Single submitter ⚠
- p.Leu99Pro Single submitter ⚠
- p.Lys162Thr Single submitter ⚠
- p.Met166Val Single submitter ⚠
- p.Phe18Ser Single submitter ⚠
- p.Pro108Thr Single submitter ⚠
- p.Pro138Ala Single submitter ⚠
- p.Pro138His Single submitter ⚠
- p.Pro97Ser Single submitter ⚠
- p.Ser55Leu Single submitter ⚠
- p.Ser79Arg Single submitter ⚠
- p.Thr152Met Single submitter ⚠
- p.Thr37Met Single submitter ⚠
- p.Thr58Met Single submitter ⚠
- p.Thr68Met Single submitter ⚠
- p.Thr84Ala Single submitter ⚠
- p.Tyr112Cys Single submitter ⚠
- p.Val100Ile Single submitter ⚠
- p.Val11Ile Single submitter ⚠
- p.Val127Ala Single submitter ⚠
- p.Val176Met Single submitter ⚠
- p.Val78Ile Single submitter ⚠