ALKBH2 — 43 ClinVar variants
All ClinVar germline ALKBH2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
8 Likely benign · 35 Uncertain significance
Full ALKBH2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALKBH2 p.Ala118Gly Uncertain significance Single submitter
- ALKBH2 p.Ala246Val Uncertain significance Single submitter
- ALKBH2 p.Arg176Lys Uncertain significance Single submitter
- ALKBH2 p.Arg248Trp Uncertain significance Single submitter
- ALKBH2 p.Arg254Cys Uncertain significance Single submitter
- ALKBH2 p.Asn154Thr Uncertain significance Single submitter
- ALKBH2 p.Gln83Glu Uncertain significance Single submitter
- ALKBH2 p.Glu88Lys Uncertain significance Single submitter
- ALKBH2 p.Glu90Asp Uncertain significance Single submitter
- ALKBH2 p.Gly11Ala Uncertain significance Single submitter
- ALKBH2 p.Gly50Ser Uncertain significance Single submitter
- ALKBH2 p.His233Tyr Uncertain significance Single submitter
- ALKBH2 p.Leu138Val Uncertain significance Single submitter
- ALKBH2 p.Leu238Phe Uncertain significance Single submitter
- ALKBH2 p.Leu251Pro Uncertain significance Single submitter
- ALKBH2 p.Lys200Glu Uncertain significance Single submitter
- ALKBH2 p.Lys7Arg Uncertain significance Single submitter
- ALKBH2 p.Pro180Ser Uncertain significance Single submitter
- ALKBH2 p.Pro41Leu Uncertain significance Single submitter
- ALKBH2 p.Ser36Arg Uncertain significance Single submitter
- ALKBH2 p.Thr230Ile Uncertain significance Single submitter
- ALKBH2 p.Thr232Met Uncertain significance Single submitter
- ALKBH2 p.Val156Leu Uncertain significance Single submitter
- ALKBH2 p.Val249Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ALKBH2 p.Ala78Thr Uncertain significance Single submitter
- ALKBH2 p.Arg142Trp Uncertain significance Single submitter
- ALKBH2 p.Arg198Gln Uncertain significance Single submitter
- ALKBH2 p.His199Arg Uncertain significance Single submitter
- ALKBH2 p.Ile158Met Uncertain significance Single submitter
- ALKBH2 p.Pro229Ala Uncertain significance Single submitter
- ALKBH2 p.Thr70Ile Uncertain significance Single submitter
- ALKBH2 p.Tyr69Cys Uncertain significance Single submitter
- ALKBH2 p.Val240Met Uncertain significance Single submitter
- ALKBH2 p.Val244Leu Uncertain significance Single submitter
All ALKBH2 variants
Likely benign 8
- p.Ala219= Single submitter
- p.Gly221= Single submitter
- p.His220= Single submitter
- p.Leu258Pro Single submitter
- p.Phe189= Single submitter
- p.Pro217= Single submitter
- p.Ser107Asn Single submitter
- p.Val244Ile Single submitter
Uncertain significance 35
- p.Ala118Gly Single submitter ⚠
- p.Ala246Val Single submitter ⚠
- p.Ala78Thr Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg176Lys Single submitter ⚠
- p.Arg198Gln Single submitter ⚠
- p.Arg248Trp Single submitter ⚠
- p.Arg254Cys Single submitter ⚠
- p.Asn154Thr Single submitter ⚠
- p.Asn231Ser Single submitter
- p.Gln83Glu Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Glu90Asp Single submitter ⚠
- p.Gly11Ala Single submitter ⚠
- p.Gly50Ser Single submitter ⚠
- p.His199Arg Single submitter ⚠
- p.His233Tyr Single submitter ⚠
- p.Ile158Met Single submitter ⚠
- p.Leu138Val Single submitter ⚠
- p.Leu238Phe Single submitter ⚠
- p.Leu251Pro Single submitter ⚠
- p.Lys200Glu Single submitter ⚠
- p.Lys7Arg Single submitter ⚠
- p.Pro180Ser Single submitter ⚠
- p.Pro229Ala Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Ser36Arg Single submitter ⚠
- p.Thr230Ile Single submitter ⚠
- p.Thr232Met Single submitter ⚠
- p.Thr70Ile Single submitter ⚠
- p.Tyr69Cys Single submitter ⚠
- p.Val156Leu Single submitter ⚠
- p.Val240Met Single submitter ⚠
- p.Val244Leu Single submitter ⚠
- p.Val249Ala Single submitter ⚠