ALKBH3 — 52 ClinVar variants
All ClinVar germline ALKBH3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
52 Uncertain significance
Full ALKBH3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALKBH3 p.Ala13Ser Uncertain significance Single submitter
- ALKBH3 p.Ala15Thr Uncertain significance Single submitter
- ALKBH3 p.Ala30Ser Uncertain significance Single submitter
- ALKBH3 p.Arg182Leu Uncertain significance Single submitter
- ALKBH3 p.Arg6Gln Uncertain significance Single submitter
- ALKBH3 p.Asn163Lys Uncertain significance Single submitter
- ALKBH3 p.Asn179Asp Uncertain significance Single submitter
- ALKBH3 p.Asp73His Uncertain significance Single submitter
- ALKBH3 p.Cys178Phe Uncertain significance Single submitter
- ALKBH3 p.Gln25His Uncertain significance Single submitter
- ALKBH3 p.Glu75Gly Uncertain significance Single submitter
- ALKBH3 p.Gly120Ser Uncertain significance Single submitter
- ALKBH3 p.Gly95Arg Uncertain significance Single submitter
- ALKBH3 p.His33Arg Uncertain significance Single submitter
- ALKBH3 p.His48Gln Uncertain significance Single submitter
- ALKBH3 p.Ile165Val Uncertain significance Single submitter
- ALKBH3 p.Leu161Val Uncertain significance Single submitter
- ALKBH3 p.Leu180Phe Uncertain significance Single submitter
- ALKBH3 p.Leu49Phe Uncertain significance Single submitter
- ALKBH3 p.Lys31Arg Uncertain significance Single submitter
- ALKBH3 p.Lys43Asn Uncertain significance Single submitter
- ALKBH3 p.Lys57Arg Uncertain significance Single submitter
- ALKBH3 p.Pro130Leu Uncertain significance Single submitter
- ALKBH3 p.Pro279Arg Uncertain significance Single submitter
- ALKBH3 p.Pro38Arg Uncertain significance Single submitter
- ALKBH3 p.Pro84Ser Uncertain significance Single submitter
- ALKBH3 p.Thr126Ile Uncertain significance Single submitter
- ALKBH3 p.Trp154Gly Uncertain significance Single submitter
- ALKBH3 p.Tyr141His Uncertain significance Single submitter
- ALKBH3 p.Tyr181His Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ALKBH3 p.Ala134Ser Uncertain significance Single submitter
- ALKBH3 p.Arg159His Uncertain significance Single submitter
- ALKBH3 p.Arg182His Uncertain significance Single submitter
- ALKBH3 p.Arg234Gly Uncertain significance Single submitter
- ALKBH3 p.Arg70Gln Uncertain significance Single submitter
- ALKBH3 p.Asn183Lys Uncertain significance Single submitter
- ALKBH3 p.Asn183Ser Uncertain significance Single submitter
- ALKBH3 p.Asp103Asn Uncertain significance Single submitter
- ALKBH3 p.Glu2Lys Uncertain significance Single submitter
- ALKBH3 p.Gly170Asp Uncertain significance Single submitter
- ALKBH3 p.Ile204Val Uncertain significance Single submitter
- ALKBH3 p.Ile72Thr Uncertain significance Single submitter
- ALKBH3 p.Ile72Val Uncertain significance Single submitter
- ALKBH3 p.Met148Ile Uncertain significance Single submitter
- ALKBH3 p.Pro152Leu Uncertain significance Single submitter
- ALKBH3 p.Pro268Leu Uncertain significance Single submitter
- ALKBH3 p.Pro279Thr Uncertain significance Single submitter
- ALKBH3 p.Pro59His Uncertain significance Single submitter
- ALKBH3 p.Pro94Thr Uncertain significance Single submitter
- ALKBH3 p.Thr214Pro Uncertain significance Single submitter
- ALKBH3 p.Val62Ile Uncertain significance Single submitter
- ALKBH3 p.Val97Ala Uncertain significance Single submitter
All ALKBH3 variants
Uncertain significance 52
- p.Ala134Ser Single submitter ⚠
- p.Ala13Ser Single submitter ⚠
- p.Ala15Thr Single submitter ⚠
- p.Ala30Ser Single submitter ⚠
- p.Arg159His Single submitter ⚠
- p.Arg182His Single submitter ⚠
- p.Arg182Leu Single submitter ⚠
- p.Arg234Gly Single submitter ⚠
- p.Arg6Gln Single submitter ⚠
- p.Arg70Gln Single submitter ⚠
- p.Asn163Lys Single submitter ⚠
- p.Asn179Asp Single submitter ⚠
- p.Asn183Lys Single submitter ⚠
- p.Asn183Ser Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Asp73His Single submitter ⚠
- p.Cys178Phe Single submitter ⚠
- p.Gln25His Single submitter ⚠
- p.Glu2Lys Single submitter ⚠
- p.Glu75Gly Single submitter ⚠
- p.Gly120Ser Single submitter ⚠
- p.Gly170Asp Single submitter ⚠
- p.Gly95Arg Single submitter ⚠
- p.His33Arg Single submitter ⚠
- p.His48Gln Single submitter ⚠
- p.Ile165Val Single submitter ⚠
- p.Ile204Val Single submitter ⚠
- p.Ile72Thr Single submitter ⚠
- p.Ile72Val Single submitter ⚠
- p.Leu161Val Single submitter ⚠
- p.Leu180Phe Single submitter ⚠
- p.Leu49Phe Single submitter ⚠
- p.Lys31Arg Single submitter ⚠
- p.Lys43Asn Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Met148Ile Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro152Leu Single submitter ⚠
- p.Pro268Leu Single submitter ⚠
- p.Pro279Arg Single submitter ⚠
- p.Pro279Thr Single submitter ⚠
- p.Pro38Arg Single submitter ⚠
- p.Pro59His Single submitter ⚠
- p.Pro84Ser Single submitter ⚠
- p.Pro94Thr Single submitter ⚠
- p.Thr126Ile Single submitter ⚠
- p.Thr214Pro Single submitter ⚠
- p.Trp154Gly Single submitter ⚠
- p.Tyr141His Single submitter ⚠
- p.Tyr181His Single submitter ⚠
- p.Val62Ile Single submitter ⚠
- p.Val97Ala Single submitter ⚠