ALKBH4 — 72 ClinVar variants
All ClinVar germline ALKBH4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
5 Likely benign · 67 Uncertain significance
Full ALKBH4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALKBH4 p.Ala238Thr Uncertain significance Single submitter
- ALKBH4 p.Ala238Val Uncertain significance Single submitter
- ALKBH4 p.Ala41Val Uncertain significance Single submitter
- ALKBH4 p.Ala4Pro Uncertain significance Single submitter
- ALKBH4 p.Ala4Thr Uncertain significance Single submitter
- ALKBH4 p.Ala6Thr Uncertain significance Single submitter
- ALKBH4 p.Arg104Gln Uncertain significance Single submitter
- ALKBH4 p.Arg104Trp Uncertain significance Single submitter
- ALKBH4 p.Arg133Gln Uncertain significance Single submitter
- ALKBH4 p.Arg133Trp Uncertain significance Single submitter
- ALKBH4 p.Arg149Trp Uncertain significance Single submitter
- ALKBH4 p.Arg179Trp Uncertain significance Single submitter
- ALKBH4 p.Arg249Trp Uncertain significance Single submitter
- ALKBH4 p.Arg264His Uncertain significance Single submitter
- ALKBH4 p.Arg264Ser Uncertain significance Single submitter
- ALKBH4 p.Arg271Gly Uncertain significance Single submitter
- ALKBH4 p.Arg271Trp Uncertain significance Single submitter
- ALKBH4 p.Arg292Gly Uncertain significance Single submitter
- ALKBH4 p.Arg30Cys Uncertain significance Single submitter
- ALKBH4 p.Arg94His Uncertain significance Single submitter
- ALKBH4 p.Asp172Asn Uncertain significance Single submitter
- ALKBH4 p.Asp51Asn Uncertain significance Single submitter
- ALKBH4 p.Asp51His Uncertain significance Single submitter
- ALKBH4 p.Cys154Arg Uncertain significance Single submitter
- ALKBH4 p.Cys154Tyr Uncertain significance Single submitter
- ALKBH4 p.Cys17Tyr Uncertain significance Single submitter
- ALKBH4 p.Cys26Ser Uncertain significance Single submitter
- ALKBH4 p.Glu123Gln Uncertain significance Single submitter
- ALKBH4 p.Glu123Lys Uncertain significance Single submitter
- ALKBH4 p.Glu152Lys Uncertain significance Single submitter
- ALKBH4 p.Glu262Gln Uncertain significance Single submitter
- ALKBH4 p.Glu276Gly Uncertain significance Single submitter
- ALKBH4 p.Glu37Ala Uncertain significance Single submitter
- ALKBH4 p.Glu64Lys Uncertain significance Single submitter
- ALKBH4 p.Glu77Gly Uncertain significance Single submitter
- ALKBH4 p.His257Arg Uncertain significance Single submitter
- ALKBH4 p.Ile25Leu Uncertain significance Single submitter
- ALKBH4 p.Leu242Val Uncertain significance Single submitter
- ALKBH4 p.Pro188Ser Uncertain significance Single submitter
- ALKBH4 p.Pro198Ser Uncertain significance Single submitter
- ALKBH4 p.Pro207Leu Uncertain significance Single submitter
- ALKBH4 p.Pro207Ser Uncertain significance Single submitter
- ALKBH4 p.Pro211Arg Uncertain significance Single submitter
- ALKBH4 p.Pro34Leu Uncertain significance Single submitter
- ALKBH4 p.Ser187Phe Uncertain significance Single submitter
- ALKBH4 p.Ser222Cys Uncertain significance Single submitter
- ALKBH4 p.Thr43Pro Uncertain significance Single submitter
- ALKBH4 p.Thr8Ala Uncertain significance Single submitter
- ALKBH4 p.Trp176Cys Uncertain significance Single submitter
- ALKBH4 p.Val218Met Uncertain significance Single submitter
- ALKBH4 p.Val230Leu Uncertain significance Single submitter
- ALKBH4 p.Val266Ile Uncertain significance Single submitter
- ALKBH4 p.Val268Ile Uncertain significance Single submitter
- ALKBH4 p.Val302Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ALKBH4 p.Arg162Trp Uncertain significance Single submitter
- ALKBH4 p.Arg223Trp Uncertain significance Single submitter
- ALKBH4 p.Arg90Trp Uncertain significance Single submitter
- ALKBH4 p.Gly199Arg Uncertain significance Single submitter
- ALKBH4 p.Gly246Arg Uncertain significance Single submitter
- ALKBH4 p.Lys18Asn Uncertain significance Single submitter
- ALKBH4 p.Lys18Glu Uncertain significance Single submitter
- ALKBH4 p.Phe125Ser Uncertain significance Single submitter
- ALKBH4 p.Pro143Leu Uncertain significance Single submitter
- ALKBH4 p.Thr269Asn Uncertain significance Single submitter
- ALKBH4 p.Val190Met Uncertain significance Single submitter
All ALKBH4 variants
Likely benign 5
- p.Ala197= Single submitter
- p.Arg82Gln Single submitter
- p.Arg90Gln Single submitter
- p.Asp95Glu Single submitter
- p.Ser205Leu Single submitter
Uncertain significance 67
- p.Ala238Thr Single submitter ⚠
- p.Ala238Val Single submitter ⚠
- p.Ala41Val Single submitter ⚠
- p.Ala4Pro Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg104Trp Single submitter ⚠
- p.Arg133Gln Single submitter ⚠
- p.Arg133Trp Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg179Trp Single submitter ⚠
- p.Arg223Trp Single submitter ⚠
- p.Arg249Trp Single submitter ⚠
- p.Arg258His Single submitter
- p.Arg264His Single submitter ⚠
- p.Arg264Ser Single submitter ⚠
- p.Arg271Gly Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg292Gly Single submitter ⚠
- p.Arg30Cys Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Asp172Asn Single submitter ⚠
- p.Asp51Asn Single submitter ⚠
- p.Asp51His Single submitter ⚠
- p.Cys154Arg Single submitter ⚠
- p.Cys154Tyr Single submitter ⚠
- p.Cys17Tyr Single submitter ⚠
- p.Cys26Ser Single submitter ⚠
- p.Glu123Gln Single submitter ⚠
- p.Glu123Lys Single submitter ⚠
- p.Glu152Lys Single submitter ⚠
- p.Glu262Gln Single submitter ⚠
- p.Glu276Gly Single submitter ⚠
- p.Glu37Ala Single submitter ⚠
- p.Glu64Lys Single submitter ⚠
- p.Glu77Gly Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly246Arg Single submitter ⚠
- p.His257Arg Single submitter ⚠
- p.Ile25Leu Single submitter ⚠
- p.Ile261Thr Single submitter
- p.Leu242Val Single submitter ⚠
- p.Lys18Asn Single submitter ⚠
- p.Lys18Glu Single submitter ⚠
- p.Phe125Ser Single submitter ⚠
- p.Pro143Leu Single submitter ⚠
- p.Pro188Ser Single submitter ⚠
- p.Pro198Ser Single submitter ⚠
- p.Pro207Leu Single submitter ⚠
- p.Pro207Ser Single submitter ⚠
- p.Pro211Arg Single submitter ⚠
- p.Pro34Leu Single submitter ⚠
- p.Ser187Phe Single submitter ⚠
- p.Ser222Cys Single submitter ⚠
- p.Thr269Asn Single submitter ⚠
- p.Thr43Pro Single submitter ⚠
- p.Thr8Ala Single submitter ⚠
- p.Trp176Cys Single submitter ⚠
- p.Val190Met Single submitter ⚠
- p.Val218Met Single submitter ⚠
- p.Val230Leu Single submitter ⚠
- p.Val266Ile Single submitter ⚠
- p.Val268Ile Single submitter ⚠
- p.Val302Leu Single submitter ⚠