ALKBH5 — 41 ClinVar variants
All ClinVar germline ALKBH5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Likely benign · 39 Uncertain significance
Full ALKBH5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALKBH5 p.Ala101Ser Uncertain significance Single submitter
- ALKBH5 p.Ala30Val Uncertain significance Single submitter
- ALKBH5 p.Ala37Val Uncertain significance Single submitter
- ALKBH5 p.Ala382Val Uncertain significance Single submitter
- ALKBH5 p.Ala386Asp Uncertain significance Single submitter
- ALKBH5 p.Ala386Thr Uncertain significance Single submitter
- ALKBH5 p.Ala46Thr Uncertain significance Single submitter
- ALKBH5 p.Arg310His Uncertain significance Single submitter
- ALKBH5 p.Arg357Gln Uncertain significance Single submitter
- ALKBH5 p.Arg93His Uncertain significance Single submitter
- ALKBH5 p.Asn120Ser Uncertain significance Single submitter
- ALKBH5 p.Asn314Lys Uncertain significance Single submitter
- ALKBH5 p.Asp309Val Uncertain significance Single submitter
- ALKBH5 p.Asp70Glu Uncertain significance Single submitter
- ALKBH5 p.Gln146Arg Uncertain significance Single submitter
- ALKBH5 p.Glu109Lys Uncertain significance Single submitter
- ALKBH5 p.Glu121Gln Uncertain significance Single submitter
- ALKBH5 p.Glu263Asp Uncertain significance Single submitter
- ALKBH5 p.Glu81Ala Uncertain significance Single submitter
- ALKBH5 p.Leu76Val Uncertain significance Single submitter
- ALKBH5 p.Pro52Arg Uncertain significance Single submitter
- ALKBH5 p.Pro66Thr Uncertain significance Single submitter
- ALKBH5 p.Ser112Phe Uncertain significance Single submitter
- ALKBH5 p.Ser299Asn Uncertain significance Single submitter
- ALKBH5 p.Thr18Met Uncertain significance Single submitter
- ALKBH5 p.Thr8Arg Uncertain significance Single submitter
- ALKBH5 p.Tyr306Cys Uncertain significance Single submitter
- ALKBH5 p.Tyr71Cys Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ALKBH5 p.Ala44Ser Uncertain significance Single submitter
- ALKBH5 p.Arg392Trp Uncertain significance Single submitter
- ALKBH5 p.Arg393Leu Uncertain significance Single submitter
- ALKBH5 p.Arg58Pro Uncertain significance Single submitter
- ALKBH5 p.Asn131Ser Uncertain significance Single submitter
- ALKBH5 p.Gln144Arg Uncertain significance Single submitter
- ALKBH5 p.Glu365Lys Uncertain significance Single submitter
- ALKBH5 p.Lys323Met Uncertain significance Single submitter
- ALKBH5 p.Pro337Leu Uncertain significance Single submitter
- ALKBH5 p.Ser16Tyr Uncertain significance Single submitter
- ALKBH5 p.Ser245Phe Uncertain significance Single submitter
All ALKBH5 variants
Uncertain significance 39
- p.Ala101Ser Single submitter ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala37Val Single submitter ⚠
- p.Ala382Val Single submitter ⚠
- p.Ala386Asp Single submitter ⚠
- p.Ala386Thr Single submitter ⚠
- p.Ala44Ser Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Arg310His Single submitter ⚠
- p.Arg357Gln Single submitter ⚠
- p.Arg392Trp Single submitter ⚠
- p.Arg393Leu Single submitter ⚠
- p.Arg58Pro Single submitter ⚠
- p.Arg93His Single submitter ⚠
- p.Asn120Ser Single submitter ⚠
- p.Asn131Ser Single submitter ⚠
- p.Asn314Lys Single submitter ⚠
- p.Asp309Val Single submitter ⚠
- p.Asp70Glu Single submitter ⚠
- p.Gln144Arg Single submitter ⚠
- p.Gln146Arg Single submitter ⚠
- p.Glu109Lys Single submitter ⚠
- p.Glu121Gln Single submitter ⚠
- p.Glu263Asp Single submitter ⚠
- p.Glu365Lys Single submitter ⚠
- p.Glu81Ala Single submitter ⚠
- p.Leu76Val Single submitter ⚠
- p.Lys323Met Single submitter ⚠
- p.Pro337Leu Single submitter ⚠
- p.Pro52Arg Single submitter ⚠
- p.Pro66Thr Single submitter ⚠
- p.Ser112Phe Single submitter ⚠
- p.Ser16Tyr Single submitter ⚠
- p.Ser245Phe Single submitter ⚠
- p.Ser299Asn Single submitter ⚠
- p.Thr18Met Single submitter ⚠
- p.Thr8Arg Single submitter ⚠
- p.Tyr306Cys Single submitter ⚠
- p.Tyr71Cys Single submitter ⚠