ALKBH6 — 34 ClinVar variants
All ClinVar germline ALKBH6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
4 Likely benign · 30 Uncertain significance
Full ALKBH6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALKBH6 p.Ala10Thr Uncertain significance Single submitter
- ALKBH6 p.Ala6Thr Uncertain significance Single submitter
- ALKBH6 p.Arg173His Uncertain significance Single submitter
- ALKBH6 p.Arg218Gly Uncertain significance Single submitter
- ALKBH6 p.Ser220Trp Uncertain significance Single submitter
- ALKBH6 p.Trp50Cys Uncertain significance Single submitter
- ALKBH6 p.Val102Met Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ALKBH6 p.Ala195Thr Likely benign Single submitter
- ALKBH6 p.Arg142Gln Likely benign Single submitter
- ALKBH6 p.Arg142Trp Uncertain significance Single submitter
- ALKBH6 p.Arg153Trp Uncertain significance Single submitter
- ALKBH6 p.Arg15Ile Uncertain significance Single submitter
- ALKBH6 p.Arg167Cys Uncertain significance Single submitter
- ALKBH6 p.Arg74Trp Uncertain significance Single submitter
- ALKBH6 p.Asn200Thr Uncertain significance Single submitter
- ALKBH6 p.Asp136Asn Uncertain significance Single submitter
- ALKBH6 p.Asp145Asn Uncertain significance Single submitter
- ALKBH6 p.Asp146Asn Uncertain significance Single submitter
- ALKBH6 p.Gln80Pro Uncertain significance Single submitter
- ALKBH6 p.Glu115Lys Uncertain significance Single submitter
- ALKBH6 p.Gly174Arg Uncertain significance Single submitter
- ALKBH6 p.Gly174Asp Uncertain significance Single submitter
- ALKBH6 p.His132Pro Uncertain significance Single submitter
- ALKBH6 p.Leu95Pro Uncertain significance Single submitter
- ALKBH6 p.Phe92Ser Uncertain significance Single submitter
- ALKBH6 p.Pro148His Uncertain significance Single submitter
- ALKBH6 p.Pro209Ser Uncertain significance Single submitter
- ALKBH6 p.Thr133Pro Uncertain significance Single submitter
- ALKBH6 p.Val16Ala Uncertain significance Single submitter
All ALKBH6 variants
Likely benign 4
- p.Ala195Thr Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Glu144= Single submitter
- p.Ser197Leu Single submitter
Uncertain significance 30
- c.-32G>A Single submitter
- c.-41G>T Single submitter
- c.-42G>A Single submitter
- p.Ala10Thr Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg15Ile Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg173His Single submitter ⚠
- p.Arg218Gly Single submitter ⚠
- p.Arg74Trp Single submitter ⚠
- p.Asn200Thr Single submitter ⚠
- p.Asp136Asn Single submitter ⚠
- p.Asp145Asn Single submitter ⚠
- p.Asp146Asn Single submitter ⚠
- p.Gln80Pro Single submitter ⚠
- p.Glu115Lys Single submitter ⚠
- p.Gly174Arg Single submitter ⚠
- p.Gly174Asp Single submitter ⚠
- p.His132Pro Single submitter ⚠
- p.Leu95Pro Single submitter ⚠
- p.Phe92Ser Single submitter ⚠
- p.Pro148His Single submitter ⚠
- p.Pro209Ser Single submitter ⚠
- p.Ser220Trp Single submitter ⚠
- p.Thr133Pro Single submitter ⚠
- p.Trp50Cys Single submitter ⚠
- p.Val102Met Single submitter ⚠
- p.Val16Ala Single submitter ⚠