ALKBH7 — 49 ClinVar variants
All ClinVar germline ALKBH7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
49 Uncertain significance
Full ALKBH7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALKBH7 p.Ala114Asp Uncertain significance Single submitter
- ALKBH7 p.Ala114Thr Uncertain significance Single submitter
- ALKBH7 p.Ala133Thr Uncertain significance Single submitter
- ALKBH7 p.Ala87Asp Uncertain significance Single submitter
- ALKBH7 p.Ala94Val Uncertain significance Single submitter
- ALKBH7 p.Arg203Cys Uncertain significance Single submitter
- ALKBH7 p.Arg203His Uncertain significance Single submitter
- ALKBH7 p.Arg50Gln Uncertain significance Single submitter
- ALKBH7 p.Arg80His Uncertain significance Single submitter
- ALKBH7 p.Asp123Val Uncertain significance Single submitter
- ALKBH7 p.Cys128Phe Uncertain significance Single submitter
- ALKBH7 p.Glu160Asp Uncertain significance Single submitter
- ALKBH7 p.Glu46Lys Uncertain significance Single submitter
- ALKBH7 p.Gly100Arg Uncertain significance Single submitter
- ALKBH7 p.Gly100Ser Uncertain significance Single submitter
- ALKBH7 p.Gly208Asp Uncertain significance Single submitter
- ALKBH7 p.Gly38Ser Uncertain significance Single submitter
- ALKBH7 p.Leu135Pro Uncertain significance Single submitter
- ALKBH7 p.Pro15His Uncertain significance Single submitter
- ALKBH7 p.Pro161Arg Uncertain significance Single submitter
- ALKBH7 p.Pro161Ser Uncertain significance Single submitter
- ALKBH7 p.Pro218His Uncertain significance Single submitter
- ALKBH7 p.Ser106Cys Uncertain significance Single submitter
- ALKBH7 p.Ser139Phe Uncertain significance Single submitter
- ALKBH7 p.Thr11Ala Uncertain significance Single submitter
- ALKBH7 p.Thr11Lys Uncertain significance Single submitter
- ALKBH7 p.Thr4Ile Uncertain significance Single submitter
- ALKBH7 p.Trp17Cys Uncertain significance Single submitter
- ALKBH7 p.Tyr165Cys Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- ALKBH7 p.Ala171Gly Uncertain significance Single submitter
- ALKBH7 p.Arg144Gln Uncertain significance Single submitter
- ALKBH7 p.Arg191Trp Uncertain significance Single submitter
- ALKBH7 p.Arg194Gln Uncertain significance Single submitter
- ALKBH7 p.Arg60Cys Uncertain significance Single submitter
- ALKBH7 p.Arg80Leu Uncertain significance Single submitter
- ALKBH7 p.Asp64Val Uncertain significance Single submitter
- ALKBH7 p.Glu77Lys Uncertain significance Single submitter
- ALKBH7 p.Gly20Asp Uncertain significance Single submitter
- ALKBH7 p.Leu89Val Uncertain significance Single submitter
- ALKBH7 p.Pro161Leu Uncertain significance Single submitter
- ALKBH7 p.Thr76Ala Uncertain significance Single submitter
- ALKBH7 p.Tyr173His Uncertain significance Single submitter
- ALKBH7 p.Val107Glu Uncertain significance Single submitter
- ALKBH7 p.Val142Phe Uncertain significance Single submitter
All ALKBH7 variants
Uncertain significance 49
- p.Ala114Asp Single submitter ⚠
- p.Ala114Thr Single submitter ⚠
- p.Ala133Thr Single submitter ⚠
- p.Ala171Gly Single submitter ⚠
- p.Ala171Thr Single submitter
- p.Ala87Asp Single submitter ⚠
- p.Ala94Val Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg168Ser Single submitter
- p.Arg191Trp Single submitter ⚠
- p.Arg194Gln Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg50Gln Single submitter ⚠
- p.Arg60Cys Single submitter ⚠
- p.Arg80His Single submitter ⚠
- p.Arg80Leu Single submitter ⚠
- p.Asp123Val Single submitter ⚠
- p.Asp64Val Single submitter ⚠
- p.Cys128Phe Single submitter ⚠
- p.Glu160Asp Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Glu77Lys Single submitter ⚠
- p.Gly100Arg Single submitter ⚠
- p.Gly100Ser Single submitter ⚠
- p.Gly208Asp Single submitter ⚠
- p.Gly20Asp Single submitter ⚠
- p.Gly38Ser Single submitter ⚠
- p.Ile166Phe Single submitter
- p.Leu135Pro Single submitter ⚠
- p.Leu137Val Single submitter
- p.Leu89Val Single submitter ⚠
- p.Pro15His Single submitter ⚠
- p.Pro161Arg Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro161Ser Single submitter ⚠
- p.Pro218His Single submitter ⚠
- p.Ser106Cys Single submitter ⚠
- p.Ser139Phe Single submitter ⚠
- p.Thr11Ala Single submitter ⚠
- p.Thr11Lys Single submitter ⚠
- p.Thr4Ile Single submitter ⚠
- p.Thr76Ala Single submitter ⚠
- p.Trp17Cys Single submitter ⚠
- p.Tyr165Cys Single submitter ⚠
- p.Tyr173His Single submitter ⚠
- p.Val107Glu Single submitter ⚠
- p.Val142Phe Single submitter ⚠
- p.Val200Met Single submitter