ALLC — 59 ClinVar variants
All ClinVar germline ALLC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
2 Benign · 5 Likely benign · 52 Uncertain significance
Full ALLC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALLC p.Ala125Ser Uncertain significance Single submitter
- ALLC p.Ala202Thr Uncertain significance Single submitter
- ALLC p.Arg274Pro Uncertain significance Single submitter
- ALLC p.Arg364Leu Uncertain significance Single submitter
- ALLC p.Arg374Lys Uncertain significance Single submitter
- ALLC p.Arg89Pro Uncertain significance Single submitter
- ALLC p.Asn156Ser Uncertain significance Single submitter
- ALLC p.Asp171Glu Uncertain significance Single submitter
- ALLC p.Cys33Arg Uncertain significance Single submitter
- ALLC p.Glu36Gln Uncertain significance Single submitter
- ALLC p.Gly181Cys Uncertain significance Single submitter
- ALLC p.Gly181Val Uncertain significance Single submitter
- ALLC p.Gly204Arg Uncertain significance Single submitter
- ALLC p.Gly209Arg Uncertain significance Single submitter
- ALLC p.Gly356Glu Uncertain significance Single submitter
- ALLC p.His268Gln Uncertain significance Single submitter
- ALLC p.Ile124Met Uncertain significance Single submitter
- ALLC p.Leu154His Uncertain significance Single submitter
- ALLC p.Leu363Pro Uncertain significance Single submitter
- ALLC p.Leu372Val Uncertain significance Single submitter
- ALLC p.Met138Ile Uncertain significance Single submitter
- ALLC p.Met3Val Uncertain significance Single submitter
- ALLC p.Phe121Cys Uncertain significance Single submitter
- ALLC p.Phe383Tyr Uncertain significance Single submitter
- ALLC p.Pro146Ala Uncertain significance Single submitter
- ALLC p.Pro319Ala Uncertain significance Single submitter
- ALLC p.Ser7Thr Uncertain significance Single submitter
- ALLC p.Thr182Pro Uncertain significance Single submitter
- ALLC p.Thr338Ser Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- ALLC p.Arg265Gln Benign Multiple submitters
- ALLC p.Ala95Glu Uncertain significance Single submitter
- ALLC p.Arg242Gln Uncertain significance Single submitter
- ALLC p.Arg242Trp Uncertain significance Single submitter
- ALLC p.Arg360His Uncertain significance Single submitter
- ALLC p.Arg55Gly Uncertain significance Single submitter
- ALLC p.Arg73Trp Uncertain significance Single submitter
- ALLC p.Asp241Tyr Uncertain significance Single submitter
- ALLC p.Asp278Gly Uncertain significance Single submitter
- ALLC p.Glu250Asp Likely benign Single submitter
- ALLC p.Glu50Asp Uncertain significance Single submitter
- ALLC p.Gly216Trp Uncertain significance Single submitter
- ALLC p.Gly74Ser Uncertain significance Single submitter
- ALLC p.Gly9Ala Uncertain significance Single submitter
- ALLC p.Ile27Thr Uncertain significance Single submitter
- ALLC p.Ile352Val Uncertain significance Single submitter
- ALLC p.Leu246Ser Uncertain significance Single submitter
- ALLC p.Pro257Leu Uncertain significance Single submitter
- ALLC p.Pro313Leu Uncertain significance Single submitter
- ALLC p.Pro32Arg Uncertain significance Single submitter
- ALLC p.Pro32Gln Uncertain significance Single submitter
- ALLC p.Pro367Ser Uncertain significance Single submitter
- ALLC p.Ser80Cys Uncertain significance Single submitter
- ALLC p.Thr324Ile Uncertain significance Single submitter
- ALLC p.Val199Met Uncertain significance Single submitter
All ALLC variants
Benign 2
- p.Arg265Gln Multiple submitters ⚠
- p.Cys290Arg Multiple submitters
Likely benign 5
- c.975+4C>T Single submitter
- p.Glu250Asp Single submitter ⚠
- p.Gly149Ser Single submitter
- p.Val305Met Single submitter
- p.Val90Met Single submitter
Uncertain significance 52
- p.Ala125Ser Single submitter ⚠
- p.Ala202Thr Single submitter ⚠
- p.Ala95Glu Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg242Trp Single submitter ⚠
- p.Arg274Pro Single submitter ⚠
- p.Arg360His Single submitter ⚠
- p.Arg364Leu Single submitter ⚠
- p.Arg374Lys Single submitter ⚠
- p.Arg55Gly Single submitter ⚠
- p.Arg73Trp Single submitter ⚠
- p.Arg89Pro Single submitter ⚠
- p.Asn156Ser Single submitter ⚠
- p.Asp171Glu Single submitter ⚠
- p.Asp241Tyr Single submitter ⚠
- p.Asp278Gly Single submitter ⚠
- p.Cys33Arg Single submitter ⚠
- p.Glu36Gln Single submitter ⚠
- p.Glu50Asp Single submitter ⚠
- p.Gly181Cys Single submitter ⚠
- p.Gly181Val Single submitter ⚠
- p.Gly204Arg Single submitter ⚠
- p.Gly209Arg Single submitter ⚠
- p.Gly216Trp Single submitter ⚠
- p.Gly356Glu Single submitter ⚠
- p.Gly74Ser Single submitter ⚠
- p.Gly9Ala Single submitter ⚠
- p.His268Gln Single submitter ⚠
- p.Ile124Met Single submitter ⚠
- p.Ile27Thr Single submitter ⚠
- p.Ile352Val Single submitter ⚠
- p.Leu154His Single submitter ⚠
- p.Leu246Ser Single submitter ⚠
- p.Leu363Pro Single submitter ⚠
- p.Leu372Val Single submitter ⚠
- p.Met138Ile Single submitter ⚠
- p.Met3Val Single submitter ⚠
- p.Phe121Cys Single submitter ⚠
- p.Phe383Tyr Single submitter ⚠
- p.Pro146Ala Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro313Leu Single submitter ⚠
- p.Pro319Ala Single submitter ⚠
- p.Pro32Arg Single submitter ⚠
- p.Pro32Gln Single submitter ⚠
- p.Pro367Ser Single submitter ⚠
- p.Ser7Thr Single submitter ⚠
- p.Ser80Cys Single submitter ⚠
- p.Thr182Pro Single submitter ⚠
- p.Thr324Ile Single submitter ⚠
- p.Thr338Ser Single submitter ⚠
- p.Val199Met Single submitter ⚠