ALOX12 — 113 ClinVar variants
All ClinVar germline ALOX12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
31 Benign · 10 Likely benign · 72 Uncertain significance
Full ALOX12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALOX12 p.Ala120Thr Uncertain significance Single submitter
- ALOX12 p.Ala12Thr Uncertain significance Single submitter
- ALOX12 p.Ala33Val Uncertain significance Single submitter
- ALOX12 p.Arg114Cys Uncertain significance Single submitter
- ALOX12 p.Arg114His Uncertain significance Single submitter
- ALOX12 p.Arg135Lys Uncertain significance Single submitter
- ALOX12 p.Arg21Ser Uncertain significance Single submitter
- ALOX12 p.Arg430Cys Uncertain significance Single submitter
- ALOX12 p.Arg500Gln Uncertain significance Single submitter
- ALOX12 p.Arg600His Uncertain significance Single submitter
- ALOX12 p.Asn119Ser Uncertain significance Single submitter
- ALOX12 p.Asp410Val Uncertain significance Single submitter
- ALOX12 p.Cys532Ser Uncertain significance Single submitter
- ALOX12 p.Gln524Glu Uncertain significance Single submitter
- ALOX12 p.Glu226Ala Uncertain significance Single submitter
- ALOX12 p.Glu501Asp Uncertain significance Single submitter
- ALOX12 p.Gly181Arg Uncertain significance Single submitter
- ALOX12 p.Gly491Glu Uncertain significance Single submitter
- ALOX12 p.Gly579Ala Uncertain significance Single submitter
- ALOX12 p.His365Asp Uncertain significance Single submitter
- ALOX12 p.His540Arg Uncertain significance Single submitter
- ALOX12 p.His68Gln Uncertain significance Single submitter
- ALOX12 p.His69Gln Uncertain significance Single submitter
- ALOX12 p.Ile393Met Uncertain significance Single submitter
- ALOX12 p.Ile663Thr Uncertain significance Single submitter
- ALOX12 p.Leu59Ile Uncertain significance Single submitter
- ALOX12 p.Lys387Glu Uncertain significance Single submitter
- ALOX12 p.Lys611Arg Uncertain significance Single submitter
- ALOX12 p.Met164Val Uncertain significance Single submitter
- ALOX12 p.Ser255Leu Uncertain significance Single submitter
- ALOX12 p.Ser350Ala Uncertain significance Single submitter
- ALOX12 p.Thr364Ile Uncertain significance Single submitter
- ALOX12 p.Thr567Ala Uncertain significance Single submitter
- ALOX12 p.Tyr191His Uncertain significance Single submitter
- ALOX12 p.Val584Ile Uncertain significance Single submitter
Predictors split 41
The independent predictors disagree with each other — read with care.
- ALOX12 p.Arg189His Benign Multiple submitters
- ALOX12 p.Ala182Pro Uncertain significance Single submitter
- ALOX12 p.Ala403Val Uncertain significance Single submitter
- ALOX12 p.Ala432Val Uncertain significance Single submitter
- ALOX12 p.Ala461Thr Uncertain significance Single submitter
- ALOX12 p.Ala75Thr Uncertain significance Single submitter
- ALOX12 p.Arg189Cys Uncertain significance Single submitter
- ALOX12 p.Arg243His Uncertain significance Single submitter
- ALOX12 p.Arg394Cys Uncertain significance Single submitter
- ALOX12 p.Arg404Gln Likely benign Single submitter
- ALOX12 p.Arg450Gln Uncertain significance Single submitter
- ALOX12 p.Arg450Trp Uncertain significance Single submitter
- ALOX12 p.Arg466Trp Uncertain significance Single submitter
- ALOX12 p.Arg599His Uncertain significance Single submitter
- ALOX12 p.Asn322Lys Uncertain significance Single submitter
- ALOX12 p.Asn625Ile Uncertain significance Single submitter
- ALOX12 p.Asp74Ala Uncertain significance Single submitter
- ALOX12 p.Gln317Arg Uncertain significance Single submitter
- ALOX12 p.Glu258Lys Uncertain significance Single submitter
- ALOX12 p.Glu265Ala Uncertain significance Single submitter
- ALOX12 p.Glu32Lys Uncertain significance Single submitter
- ALOX12 p.Glu34Lys Uncertain significance Single submitter
- ALOX12 p.Gly411Ala Uncertain significance Single submitter
- ALOX12 p.Ile390Thr Uncertain significance Single submitter
- ALOX12 p.Ile471Met Uncertain significance Single submitter
- ALOX12 p.Ile502Phe Uncertain significance Single submitter
- ALOX12 p.Leu132Arg Uncertain significance Single submitter
- ALOX12 p.Leu183Pro Uncertain significance Single submitter
- ALOX12 p.Lys133Asn Likely benign Single submitter
- ALOX12 p.Pro149Leu Uncertain significance Single submitter
- ALOX12 p.Pro161Ser Uncertain significance Single submitter
- ALOX12 p.Pro337Arg Uncertain significance Single submitter
- ALOX12 p.Pro566Thr Uncertain significance Single submitter
- ALOX12 p.Pro606Ala Uncertain significance Single submitter
- ALOX12 p.Pro618Leu Uncertain significance Single submitter
- ALOX12 p.Ser334Leu Uncertain significance Single submitter
- ALOX12 p.Thr329Ile Uncertain significance Single submitter
- ALOX12 p.Thr329Lys Uncertain significance Single submitter
- ALOX12 p.Thr535Met Uncertain significance Single submitter
- ALOX12 p.Thr573Met Uncertain significance Single submitter
- ALOX12 p.Val92Ala Likely benign Single submitter
All ALOX12 variants
Benign 31
- c.1161+228C>T Multiple submitters
- c.135+58C>T Multiple submitters
- c.136-69G>A Multiple submitters
- c.1418+32C>T Multiple submitters
- c.1541-20G>A Multiple submitters
- c.1541-264T>A Multiple submitters
- c.337+16C>T Multiple submitters
- c.337+37T>C Multiple submitters
- c.337+98T>G Multiple submitters
- c.542+23G>A Multiple submitters
- c.646+84T>C Multiple submitters
- c.807+102A>G Multiple submitters
- c.807+25A>T Multiple submitters
- c.808-118G>A Multiple submitters
- p.Arg189His Multiple submitters ⚠
- p.Arg430His Multiple submitters
- p.Asn322Ser Multiple submitters
- p.Gln261Arg Multiple submitters
- p.Gln484= Multiple submitters
- p.Leu634= Multiple submitters
- p.Pro41= Multiple submitters
- p.Ser255= Multiple submitters
- p.Thr364= Multiple submitters
- c.1248+241G>A Single submitter
- c.135+160T>C Single submitter
- c.1418+32_1418+33del Single submitter
- c.1540+282A>G Single submitter
- c.1540+285T>G Single submitter
- c.338-156G>A Single submitter
- c.951+146G>A Single submitter
- c.951+200C>T Single submitter
Likely benign 10
- p.Ala343= Single submitter
- p.Arg404Gln Single submitter ⚠
- p.Arg585Gln Single submitter
- p.Cys140Arg Single submitter
- p.Cys532= Single submitter
- p.Gly117Arg Single submitter
- p.Lys133Asn Single submitter ⚠
- p.Lys266Arg Single submitter
- p.Val92Ala Single submitter ⚠
- c.1418+40_1418+41insTG No assertion criteria ALOX12-related condition
Uncertain significance 72
- p.Ala120Thr Single submitter ⚠
- p.Ala12Thr Single submitter ⚠
- p.Ala182Pro Single submitter ⚠
- p.Ala33Val Single submitter ⚠
- p.Ala403Val Single submitter ⚠
- p.Ala432Val Single submitter ⚠
- p.Ala461Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg114His Single submitter ⚠
- p.Arg135Lys Single submitter ⚠
- p.Arg189Cys Single submitter ⚠
- p.Arg21Ser Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg394Cys Single submitter ⚠
- p.Arg430Cys Single submitter ⚠
- p.Arg450Gln Single submitter ⚠
- p.Arg450Trp Single submitter ⚠
- p.Arg466Trp Single submitter ⚠
- p.Arg500Gln Single submitter ⚠
- p.Arg599His Single submitter ⚠
- p.Arg600His Single submitter ⚠
- p.Asn119Ser Single submitter ⚠
- p.Asn322Lys Single submitter ⚠
- p.Asn625Ile Single submitter ⚠
- p.Asp410Val Single submitter ⚠
- p.Asp74Ala Single submitter ⚠
- p.Cys532Ser Single submitter ⚠
- p.Gln317Arg Single submitter ⚠
- p.Gln524Glu Single submitter ⚠
- p.Glu226Ala Single submitter ⚠
- p.Glu258Lys Single submitter ⚠
- p.Glu265Ala Single submitter ⚠
- p.Glu32Lys Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Glu501Asp Single submitter ⚠
- p.Gly181Arg Single submitter ⚠
- p.Gly411Ala Single submitter ⚠
- p.Gly491Glu Single submitter ⚠
- p.Gly579Ala Single submitter ⚠
- p.His365Asp Single submitter ⚠
- p.His540Arg Single submitter ⚠
- p.His68Gln Single submitter ⚠
- p.His69Gln Single submitter ⚠
- p.Ile390Thr Single submitter ⚠
- p.Ile393Met Single submitter ⚠
- p.Ile471Met Single submitter ⚠
- p.Ile502Phe Single submitter ⚠
- p.Ile663Thr Single submitter ⚠
- p.Leu132Arg Single submitter ⚠
- p.Leu183Pro Single submitter ⚠
- p.Leu59Ile Single submitter ⚠
- p.Lys387Glu Single submitter ⚠
- p.Lys611Arg Single submitter ⚠
- p.Met164Val Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro161Ser Single submitter ⚠
- p.Pro337Arg Single submitter ⚠
- p.Pro566Thr Single submitter ⚠
- p.Pro606Ala Single submitter ⚠
- p.Pro618Leu Single submitter ⚠
- p.Ser255Leu Single submitter ⚠
- p.Ser334Leu Single submitter ⚠
- p.Ser350Ala Single submitter ⚠
- p.Thr329Ile Single submitter ⚠
- p.Thr329Lys Single submitter ⚠
- p.Thr364Ile Single submitter ⚠
- p.Thr535Met Single submitter ⚠
- p.Thr567Ala Single submitter ⚠
- p.Thr573Met Single submitter ⚠
- p.Tyr191His Single submitter ⚠
- p.Val584Ile Single submitter ⚠