ALOX15 — 110 ClinVar variants
All ClinVar germline ALOX15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
9 Benign · 10 Likely benign · 91 Uncertain significance
Full ALOX15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALOX15 p.Ala434Val Uncertain significance Single submitter
- ALOX15 p.Ala75Gly Uncertain significance Single submitter
- ALOX15 p.Arg114Cys Uncertain significance Single submitter
- ALOX15 p.Arg136Lys Uncertain significance Single submitter
- ALOX15 p.Arg165Gln Uncertain significance Single submitter
- ALOX15 p.Arg38Gly Uncertain significance Single submitter
- ALOX15 p.Arg404Gly Uncertain significance Single submitter
- ALOX15 p.Arg466Gln Uncertain significance Single submitter
- ALOX15 p.Arg68Gln Uncertain significance Single submitter
- ALOX15 p.Arg68Trp Uncertain significance Single submitter
- ALOX15 p.Asn20Ser Uncertain significance Single submitter
- ALOX15 p.Asp463Val Uncertain significance Single submitter
- ALOX15 p.Cys196Tyr Uncertain significance Single submitter
- ALOX15 p.Cys96Tyr Uncertain significance Single submitter
- ALOX15 p.Gln121Arg Uncertain significance Single submitter
- ALOX15 p.Gln511Arg Uncertain significance Single submitter
- ALOX15 p.Gly104Ala Uncertain significance Single submitter
- ALOX15 p.Gly111Arg Uncertain significance Single submitter
- ALOX15 p.Gly181Trp Uncertain significance Single submitter
- ALOX15 p.Gly270Arg Uncertain significance Single submitter
- ALOX15 p.His295Leu Uncertain significance Single submitter
- ALOX15 p.His383Arg Uncertain significance Single submitter
- ALOX15 p.His584Tyr Uncertain significance Single submitter
- ALOX15 p.Ile478Met Uncertain significance Single submitter
- ALOX15 p.Ile639Thr Uncertain significance Single submitter
- ALOX15 p.Met561Ile Uncertain significance Single submitter
- ALOX15 p.Met577Val Uncertain significance Single submitter
- ALOX15 p.Pro255Ala Uncertain significance Single submitter
- ALOX15 p.Pro384Arg Uncertain significance Single submitter
- ALOX15 p.Pro384Leu Uncertain significance Single submitter
- ALOX15 p.Pro41Leu Uncertain significance Single submitter
- ALOX15 p.Ser13Trp Uncertain significance Single submitter
- ALOX15 p.Ser542Phe Uncertain significance Single submitter
- ALOX15 p.Ser659Ile Uncertain significance Single submitter
- ALOX15 p.Thr375Ala Uncertain significance Single submitter
- ALOX15 p.Tyr395His Uncertain significance Single submitter
- ALOX15 p.Val288Ile Uncertain significance Single submitter
- ALOX15 p.Val426Met Uncertain significance Single submitter
- ALOX15 p.Val576Glu Uncertain significance Single submitter
- ALOX15 p.Val655Met Uncertain significance Single submitter
Predictors split 53
The independent predictors disagree with each other — read with care.
- ALOX15 p.Arg205Gln Benign Multiple submitters
- ALOX15 p.Gly102Val Uncertain significance Multiple submitters
- ALOX15 p.Val426Gly Likely benign Multiple submitters
- ALOX15 p.Ala16Val Uncertain significance Single submitter
- ALOX15 p.Ala541Thr Uncertain significance Single submitter
- ALOX15 p.Ala578Val Uncertain significance Single submitter
- ALOX15 p.Ala631Val Uncertain significance Single submitter
- ALOX15 p.Arg128Gln Uncertain significance Single submitter
- ALOX15 p.Arg348Cys Uncertain significance Single submitter
- ALOX15 p.Arg348His Uncertain significance Single submitter
- ALOX15 p.Arg450Gln Uncertain significance Single submitter
- ALOX15 p.Arg450Trp Uncertain significance Single submitter
- ALOX15 p.Arg466Trp Uncertain significance Single submitter
- ALOX15 p.Arg473Trp Uncertain significance Single submitter
- ALOX15 p.Arg513Gln Uncertain significance Single submitter
- ALOX15 p.Arg522Gln Uncertain significance Single submitter
- ALOX15 p.Arg522Pro Uncertain significance Single submitter
- ALOX15 p.Arg562Trp Uncertain significance Single submitter
- ALOX15 p.Arg640Gln Uncertain significance Single submitter
- ALOX15 p.Asn192Asp Uncertain significance Single submitter
- ALOX15 p.Asn658Lys Uncertain significance Single submitter
- ALOX15 p.Asp225Asn Uncertain significance Single submitter
- ALOX15 p.Asp282Gly Uncertain significance Single submitter
- ALOX15 p.Asp415His Uncertain significance Single submitter
- ALOX15 p.Asp492Asn Uncertain significance Single submitter
- ALOX15 p.Asp634Gly Uncertain significance Single submitter
- ALOX15 p.Glu101Asp Uncertain significance Single submitter
- ALOX15 p.Glu275Lys Uncertain significance Single submitter
- ALOX15 p.Glu46Gly Uncertain significance Single submitter
- ALOX15 p.Glu612Gly Uncertain significance Single submitter
- ALOX15 p.Glu91Lys Uncertain significance Single submitter
- ALOX15 p.Gly147Trp Uncertain significance Single submitter
- ALOX15 p.Gly28Ser Uncertain significance Single submitter
- ALOX15 p.Gly324Arg Uncertain significance Single submitter
- ALOX15 p.His544Asp Uncertain significance Single submitter
- ALOX15 p.His609Arg Uncertain significance Single submitter
- ALOX15 p.Ile637Thr Uncertain significance Single submitter
- ALOX15 p.Leu178Pro Uncertain significance Single submitter
- ALOX15 p.Leu330Phe Uncertain significance Single submitter
- ALOX15 p.Lys50Asn Uncertain significance Single submitter
- ALOX15 p.Phe274Leu Uncertain significance Single submitter
- ALOX15 p.Pro161Leu Uncertain significance Single submitter
- ALOX15 p.Pro516Ser Uncertain significance Single submitter
- ALOX15 p.Pro619Arg Uncertain significance Single submitter
- ALOX15 p.Ser190Cys Uncertain significance Single submitter
- ALOX15 p.Ser279Cys Uncertain significance Single submitter
- ALOX15 p.Thr334Met Uncertain significance Single submitter
- ALOX15 p.Trp197Arg Uncertain significance Single submitter
- ALOX15 p.Tyr483Ser Uncertain significance Single submitter
- ALOX15 p.Val105Phe Uncertain significance Single submitter
- ALOX15 p.Val218Met Uncertain significance Single submitter
- ALOX15 p.Val83Gly Uncertain significance Single submitter
- ALOX15 p.Val8Leu Likely benign Single submitter
All ALOX15 variants
Benign 9
- c.1418+9A>G Multiple submitters
- p.Arg205Gln Multiple submitters ⚠
- p.Arg348= Multiple submitters
- p.Asn103Lys Multiple submitters
- p.Pro565= Multiple submitters
- p.Pro617Ser Multiple submitters
- p.Leu296= Single submitter
- p.Pro647= Single submitter
- p.Thr560Met Single submitter asthma, nasal polyps, and aspirin intolerance
Likely benign 10
- p.Asp90His Multiple submitters
- p.Val426Gly Multiple submitters ⚠
- p.Asn19Lys Single submitter
- p.Asn79Ser Single submitter
- p.Ile413Val Single submitter
- p.Leu157= Single submitter
- p.Met603Val Single submitter
- p.Pro601= Single submitter
- p.Val602Ile Single submitter
- p.Val8Leu Single submitter ⚠
Uncertain significance 91
- p.Gly102Val Multiple submitters ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala434Val Single submitter ⚠
- p.Ala541Thr Single submitter ⚠
- p.Ala578Val Single submitter ⚠
- p.Ala631Val Single submitter ⚠
- p.Ala75Gly Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg128Gln Single submitter ⚠
- p.Arg136Lys Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg348Cys Single submitter ⚠
- p.Arg348His Single submitter ⚠
- p.Arg38Gly Single submitter ⚠
- p.Arg394Ter Single submitter
- p.Arg404Gly Single submitter ⚠
- p.Arg450Gln Single submitter ⚠
- p.Arg450Trp Single submitter ⚠
- p.Arg466Gln Single submitter ⚠
- p.Arg466Trp Single submitter ⚠
- p.Arg473Trp Single submitter ⚠
- p.Arg513Gln Single submitter ⚠
- p.Arg522Gln Single submitter ⚠
- p.Arg522Pro Single submitter ⚠
- p.Arg562Trp Single submitter ⚠
- p.Arg640Gln Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Arg68Trp Single submitter ⚠
- p.Asn192Asp Single submitter ⚠
- p.Asn20Ser Single submitter ⚠
- p.Asn658Lys Single submitter ⚠
- p.Asp225Asn Single submitter ⚠
- p.Asp282Gly Single submitter ⚠
- p.Asp415His Single submitter ⚠
- p.Asp463Val Single submitter ⚠
- p.Asp492Asn Single submitter ⚠
- p.Asp634Gly Single submitter ⚠
- p.Cys196Tyr Single submitter ⚠
- p.Cys96Tyr Single submitter ⚠
- p.Gln121Arg Single submitter ⚠
- p.Gln511Arg Single submitter ⚠
- p.Glu101Asp Single submitter ⚠
- p.Glu275Lys Single submitter ⚠
- p.Glu46Gly Single submitter ⚠
- p.Glu612Gly Single submitter ⚠
- p.Glu91Lys Single submitter ⚠
- p.Gly104Ala Single submitter ⚠
- p.Gly111Arg Single submitter ⚠
- p.Gly147Trp Single submitter ⚠
- p.Gly181Trp Single submitter ⚠
- p.Gly270Arg Single submitter ⚠
- p.Gly28Ser Single submitter ⚠
- p.Gly324Arg Single submitter ⚠
- p.His295Leu Single submitter ⚠
- p.His383Arg Single submitter ⚠
- p.His544Asp Single submitter ⚠
- p.His584Tyr Single submitter ⚠
- p.His609Arg Single submitter ⚠
- p.Ile478Met Single submitter ⚠
- p.Ile637Thr Single submitter ⚠
- p.Ile639Thr Single submitter ⚠
- p.Leu178Pro Single submitter ⚠
- p.Leu330Phe Single submitter ⚠
- p.Lys50Asn Single submitter ⚠
- p.Met561Ile Single submitter ⚠
- p.Met577Val Single submitter ⚠
- p.Phe274Leu Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro255Ala Single submitter ⚠
- p.Pro384Arg Single submitter ⚠
- p.Pro384Leu Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Pro516Ser Single submitter ⚠
- p.Pro619Arg Single submitter ⚠
- p.Ser13Trp Single submitter ⚠
- p.Ser190Cys Single submitter ⚠
- p.Ser279Cys Single submitter ⚠
- p.Ser542Phe Single submitter ⚠
- p.Ser659Ile Single submitter ⚠
- p.Thr334Met Single submitter ⚠
- p.Thr375Ala Single submitter ⚠
- p.Trp197Arg Single submitter ⚠
- p.Tyr395His Single submitter ⚠
- p.Tyr483Ser Single submitter ⚠
- p.Val105Phe Single submitter ⚠
- p.Val218Met Single submitter ⚠
- p.Val288Ile Single submitter ⚠
- p.Val426Met Single submitter ⚠
- p.Val576Glu Single submitter ⚠
- p.Val655Met Single submitter ⚠
- p.Val83Gly Single submitter ⚠