ALOX5 — 94 ClinVar variants
All ClinVar germline ALOX5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
1 Benign · 12 Likely benign · 81 Uncertain significance
Full ALOX5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALOX5 p.Ala158Asp Uncertain significance Single submitter
- ALOX5 p.Ala30Gly Uncertain significance Single submitter
- ALOX5 p.Ala30Val Uncertain significance Single submitter
- ALOX5 p.Ala50Val Uncertain significance Single submitter
- ALOX5 p.Arg116Cys Uncertain significance Single submitter
- ALOX5 p.Arg116His Uncertain significance Single submitter
- ALOX5 p.Arg121Gln Uncertain significance Single submitter
- ALOX5 p.Arg133His Uncertain significance Single submitter
- ALOX5 p.Arg139Trp Uncertain significance Single submitter
- ALOX5 p.Arg166His Uncertain significance Single submitter
- ALOX5 p.Arg166Leu Uncertain significance Single submitter
- ALOX5 p.Arg269Gln Uncertain significance Single submitter
- ALOX5 p.Arg356Cys Uncertain significance Single submitter
- ALOX5 p.Arg385His Uncertain significance Single submitter
- ALOX5 p.Arg667Gln Uncertain significance Single submitter
- ALOX5 p.Arg667Gly Uncertain significance Single submitter
- ALOX5 p.Arg667Trp Uncertain significance Single submitter
- ALOX5 p.Asn192Ser Uncertain significance Single submitter
- ALOX5 p.Asn225Ser Uncertain significance Single submitter
- ALOX5 p.Asn511Ser Uncertain significance Single submitter
- ALOX5 p.Asn567Ile Uncertain significance Single submitter
- ALOX5 p.Asn78Ser Uncertain significance Single submitter
- ALOX5 p.Asp163Glu Uncertain significance Single submitter
- ALOX5 p.Asp294Ala Uncertain significance Single submitter
- ALOX5 p.Asp294Asn Uncertain significance Single submitter
- ALOX5 p.Asp299Glu Uncertain significance Single submitter
- ALOX5 p.Glu335Lys Uncertain significance Single submitter
- ALOX5 p.Glu502Lys Uncertain significance Single submitter
- ALOX5 p.Gly49Asp Uncertain significance Single submitter
- ALOX5 p.His126Arg Uncertain significance Single submitter
- ALOX5 p.His368Tyr Uncertain significance Single submitter
- ALOX5 p.His400Arg Uncertain significance Single submitter
- ALOX5 p.Ile22Val Uncertain significance Single submitter
- ALOX5 p.Ile293Val Uncertain significance Single submitter
- ALOX5 p.Ile393Val Uncertain significance Single submitter
- ALOX5 p.Lys118Asn Uncertain significance Single submitter
- ALOX5 p.Lys442Arg Uncertain significance Single submitter
- ALOX5 p.Lys84Arg Uncertain significance Single submitter
- ALOX5 p.Met383Val Uncertain significance Single submitter
- ALOX5 p.Phe470Tyr Uncertain significance Single submitter
- ALOX5 p.Pro452Ser Uncertain significance Single submitter
- ALOX5 p.Pro504Leu Uncertain significance Single submitter
- ALOX5 p.Ser462Asn Uncertain significance Single submitter
- ALOX5 p.Thr372Ile Uncertain significance Single submitter
- ALOX5 p.Tyr346Asn Uncertain significance Single submitter
- ALOX5 p.Tyr468Cys Uncertain significance Single submitter
- ALOX5 p.Val179Ile Uncertain significance Single submitter
- ALOX5 p.Val213Ile Uncertain significance Single submitter
- ALOX5 p.Val362Ile Uncertain significance Single submitter
- ALOX5 p.Val375Gly Uncertain significance Single submitter
- ALOX5 p.Val401Met Uncertain significance Single submitter
-
ALOX5 p.Leu164Val
Uncertain significance
No assertion criteria
breast ductal adenocarcinoma
Predictors split 30
The independent predictors disagree with each other — read with care.
- ALOX5 p.Ala308Ser Uncertain significance Single submitter
- ALOX5 p.Ala308Thr Uncertain significance Single submitter
- ALOX5 p.Ala447Val Uncertain significance Single submitter
- ALOX5 p.Ala607Val Uncertain significance Single submitter
- ALOX5 p.Arg133Cys Likely benign Single submitter
- ALOX5 p.Arg247Trp Uncertain significance Single submitter
- ALOX5 p.Arg248His Uncertain significance Single submitter
- ALOX5 p.Arg269Gly Uncertain significance Single submitter
- ALOX5 p.Asn329Ser Likely benign Single submitter
- ALOX5 p.Asp107Asn Uncertain significance Single submitter
- ALOX5 p.Asp114Ala Uncertain significance Single submitter
- ALOX5 p.Asp114Gly Uncertain significance Single submitter
- ALOX5 p.Asp207Asn Uncertain significance Single submitter
- ALOX5 p.Asp20Asn Uncertain significance Single submitter
- ALOX5 p.Cys32Gly Uncertain significance Single submitter
- ALOX5 p.Gly557Ser Uncertain significance Single submitter
- ALOX5 p.Ile455Met Uncertain significance Single submitter
- ALOX5 p.Leu180Arg Uncertain significance Single submitter
- ALOX5 p.Leu476His Uncertain significance Single submitter
- ALOX5 p.Leu476Phe Uncertain significance Single submitter
- ALOX5 p.Met232Ile Uncertain significance Single submitter
- ALOX5 p.Phe190Leu Uncertain significance Single submitter
- ALOX5 p.Ser647Ile Uncertain significance Single submitter
- ALOX5 p.Thr571Asn Uncertain significance Single submitter
- ALOX5 p.Tyr101Cys Uncertain significance Single submitter
- ALOX5 p.Val27Glu Uncertain significance Single submitter
- ALOX5 p.Val56Met Uncertain significance Single submitter
- ALOX5 p.Val582Met Uncertain significance Single submitter
- ALOX5 p.Val583Gly Uncertain significance Single submitter
- ALOX5 p.Val648Met Uncertain significance Single submitter
All ALOX5 variants
Benign 1
- p.Gly106= Multiple submitters
Likely benign 12
- c.981+9C>T Single submitter
- p.Ala185= Single submitter
- p.Arg133Cys Single submitter ⚠
- p.Arg144= Single submitter
- p.Arg247Gln Single submitter
- p.Asn329Ser Single submitter ⚠
- p.Asp107Glu Single submitter
- p.Asp79= Single submitter
- p.Gly496Ser Single submitter
- p.Ile70= Single submitter
- p.Val110Ile Single submitter
- p.Val285= Single submitter
Uncertain significance 81
- p.Ala158Asp Single submitter ⚠
- p.Ala308Ser Single submitter ⚠
- p.Ala308Thr Single submitter ⚠
- p.Ala30Gly Single submitter ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala447Val Single submitter ⚠
- p.Ala50Val Single submitter ⚠
- p.Ala607Val Single submitter ⚠
- p.Arg116Cys Single submitter ⚠
- p.Arg116His Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg133His Single submitter ⚠
- p.Arg139Trp Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Arg166Leu Single submitter ⚠
- p.Arg247Trp Single submitter ⚠
- p.Arg248His Single submitter ⚠
- p.Arg269Gln Single submitter ⚠
- p.Arg269Gly Single submitter ⚠
- p.Arg356Cys Single submitter ⚠
- p.Arg385His Single submitter ⚠
- p.Arg667Gln Single submitter ⚠
- p.Arg667Gly Single submitter ⚠
- p.Arg667Trp Single submitter ⚠
- p.Asn192Ser Single submitter ⚠
- p.Asn225Ser Single submitter ⚠
- p.Asn511Ser Single submitter ⚠
- p.Asn567Ile Single submitter ⚠
- p.Asn78Ser Single submitter ⚠
- p.Asp107Asn Single submitter ⚠
- p.Asp114Ala Single submitter ⚠
- p.Asp114Gly Single submitter ⚠
- p.Asp163Glu Single submitter ⚠
- p.Asp207Asn Single submitter ⚠
- p.Asp20Asn Single submitter ⚠
- p.Asp294Ala Single submitter ⚠
- p.Asp294Asn Single submitter ⚠
- p.Asp299Glu Single submitter ⚠
- p.Cys32Gly Single submitter ⚠
- p.Glu335Lys Single submitter ⚠
- p.Glu502Lys Single submitter ⚠
- p.Gly49Asp Single submitter ⚠
- p.Gly557Ser Single submitter ⚠
- p.His126Arg Single submitter ⚠
- p.His368Tyr Single submitter ⚠
- p.His400Arg Single submitter ⚠
- p.Ile22Val Single submitter ⚠
- p.Ile293Val Single submitter ⚠
- p.Ile393Val Single submitter ⚠
- p.Ile455Met Single submitter ⚠
- p.Leu180Arg Single submitter ⚠
- p.Leu476His Single submitter ⚠
- p.Leu476Phe Single submitter ⚠
- p.Lys118Asn Single submitter ⚠
- p.Lys442Arg Single submitter ⚠
- p.Lys84Arg Single submitter ⚠
- p.Met232Ile Single submitter ⚠
- p.Met383Val Single submitter ⚠
- p.Phe190Leu Single submitter ⚠
- p.Phe470Tyr Single submitter ⚠
- p.Pro452Ser Single submitter ⚠
- p.Pro504Leu Single submitter ⚠
- p.Ser29Ter Single submitter
- p.Ser462Asn Single submitter ⚠
- p.Ser647Ile Single submitter ⚠
- p.Thr372Ile Single submitter ⚠
- p.Thr571Asn Single submitter ⚠
- p.Tyr101Cys Single submitter ⚠
- p.Tyr346Asn Single submitter ⚠
- p.Tyr468Cys Single submitter ⚠
- p.Val179Ile Single submitter ⚠
- p.Val213Ile Single submitter ⚠
- p.Val27Glu Single submitter ⚠
- p.Val362Ile Single submitter ⚠
- p.Val375Gly Single submitter ⚠
- p.Val401Met Single submitter ⚠
- p.Val56Met Single submitter ⚠
- p.Val582Met Single submitter ⚠
- p.Val583Gly Single submitter ⚠
- p.Val648Met Single submitter ⚠
- p.Leu164Val No assertion criteria breast ductal adenocarcinoma ⚠