ALPG — 126 ClinVar variants
All ClinVar germline ALPG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
9 Benign · 1 Benign/Likely benign · 14 Likely benign · 102 Uncertain significance
Full ALPG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALPG p.Ala135Thr Uncertain significance Single submitter
- ALPG p.Ala406Thr Uncertain significance Single submitter
- ALPG p.Ala48Thr Uncertain significance Single submitter
- ALPG p.Ala492Val Uncertain significance Single submitter
- ALPG p.Arg136Leu Uncertain significance Single submitter
- ALPG p.Arg154Trp Uncertain significance Single submitter
- ALPG p.Arg169Trp Uncertain significance Single submitter
- ALPG p.Arg185Cys Uncertain significance Single submitter
- ALPG p.Arg425Pro Uncertain significance Single submitter
- ALPG p.Arg439Gln Uncertain significance Single submitter
- ALPG p.Asn184His Uncertain significance Single submitter
- ALPG p.Asp233Glu Uncertain significance Single submitter
- ALPG p.Asp376Asn Uncertain significance Single submitter
- ALPG p.Cys120Trp Uncertain significance Single submitter
- ALPG p.Gln2Leu Uncertain significance Single submitter
- ALPG p.Glu367Asp Uncertain significance Single submitter
- ALPG p.Glu37Ala Uncertain significance Single submitter
- ALPG p.Glu454Lys Uncertain significance Single submitter
- ALPG p.Gly121Arg Uncertain significance Single submitter
- ALPG p.Gly124Ser Uncertain significance Single submitter
- ALPG p.Gly177Ser Uncertain significance Single submitter
- ALPG p.Gly399Asp Uncertain significance Single submitter
- ALPG p.Gly3Val Uncertain significance Single submitter
- ALPG p.Gly62Glu Uncertain significance Single submitter
- ALPG p.Gly62Val Uncertain significance Single submitter
- ALPG p.Gly64Arg Uncertain significance Single submitter
- ALPG p.Ile149Thr Uncertain significance Single submitter
- ALPG p.Ile57Val Uncertain significance Single submitter
- ALPG p.Leu495Val Uncertain significance Single submitter
- ALPG p.Lys160Asn Uncertain significance Single submitter
- ALPG p.Lys224Asn Uncertain significance Single submitter
- ALPG p.Lys259Thr Uncertain significance Single submitter
- ALPG p.Met308Thr Uncertain significance Single submitter
- ALPG p.Pro305Ser Uncertain significance Single submitter
- ALPG p.Pro497Leu Uncertain significance Single submitter
- ALPG p.Pro509Ala Uncertain significance Single submitter
- ALPG p.Pro509Ser Uncertain significance Single submitter
- ALPG p.Ser306Phe Uncertain significance Single submitter
- ALPG p.Ser431Asn Uncertain significance Single submitter
- ALPG p.Ser433Arg Uncertain significance Single submitter
- ALPG p.Thr207Met Uncertain significance Single submitter
- ALPG p.Thr374Asn Uncertain significance Single submitter
- ALPG p.Thr50Arg Uncertain significance Single submitter
- ALPG p.Thr86Asn Uncertain significance Single submitter
- ALPG p.Trp267Arg Uncertain significance Single submitter
- ALPG p.Trp267Cys Uncertain significance Single submitter
- ALPG p.Tyr412Asp Uncertain significance Single submitter
- ALPG p.Val471Glu Uncertain significance Single submitter
Predictors split 60
The independent predictors disagree with each other — read with care.
- ALPG p.Pro228Arg Benign Multiple submitters
- ALPG p.Pro94Ser Benign Multiple submitters
- ALPG p.Tyr95Phe Benign Multiple submitters
- ALPG p.Ala180Thr Uncertain significance Single submitter
- ALPG p.Ala206Thr Uncertain significance Single submitter
- ALPG p.Ala263Thr Uncertain significance Single submitter
- ALPG p.Ala360Val Uncertain significance Single submitter
- ALPG p.Ala42Thr Uncertain significance Single submitter
- ALPG p.Ala52Thr Uncertain significance Single submitter
- ALPG p.Ala89Val Uncertain significance Single submitter
- ALPG p.Arg136Cys Uncertain significance Single submitter
- ALPG p.Arg144Cys Uncertain significance Single submitter
- ALPG p.Arg198Gly Uncertain significance Single submitter
- ALPG p.Arg198His Uncertain significance Single submitter
- ALPG p.Arg223Gln Likely benign Single submitter
- ALPG p.Arg264Gln Likely benign Single submitter
- ALPG p.Arg33Cys Uncertain significance Single submitter
- ALPG p.Arg33His Uncertain significance Single submitter
- ALPG p.Arg92Cys Uncertain significance Single submitter
- ALPG p.Arg92His Likely benign Single submitter
- ALPG p.Asn268Lys Uncertain significance Single submitter
- ALPG p.Asp278Asn Uncertain significance Single submitter
- ALPG p.Asp422Glu Uncertain significance Single submitter
- ALPG p.Cys120Ser Uncertain significance Single submitter
- ALPG p.Cys493Arg Uncertain significance Single submitter
- ALPG p.Gln441Leu Uncertain significance Single submitter
- ALPG p.Glu147Lys Uncertain significance Single submitter
- ALPG p.Glu430Lys Uncertain significance Single submitter
- ALPG p.Gly201Arg Uncertain significance Single submitter
- ALPG p.Gly390Glu Uncertain significance Single submitter
- ALPG p.Gly423Ser Uncertain significance Single submitter
- ALPG p.Gly470Ser Uncertain significance Single submitter
- ALPG p.Gly527Glu Uncertain significance Single submitter
- ALPG p.His181Tyr Uncertain significance Single submitter
- ALPG p.His466Tyr Uncertain significance Single submitter
- ALPG p.Leu524Pro Uncertain significance Single submitter
- ALPG p.Leu8Phe Uncertain significance Single submitter
- ALPG p.Lys421Glu Uncertain significance Single submitter
- ALPG p.Phe394Leu Uncertain significance Single submitter
- ALPG p.Pro175Leu Uncertain significance Single submitter
- ALPG p.Pro232Ser Uncertain significance Single submitter
- ALPG p.Pro445Ser Uncertain significance Single submitter
- ALPG p.Ser189Leu Uncertain significance Single submitter
- ALPG p.Ser196Leu Uncertain significance Single submitter
- ALPG p.Ser306Pro Uncertain significance Single submitter
- ALPG p.Ser319Asn Uncertain significance Single submitter
- ALPG p.Ser382Phe Uncertain significance Single submitter
- ALPG p.Thr101Ile Uncertain significance Single submitter
- ALPG p.Thr142Met Uncertain significance Single submitter
- ALPG p.Thr182Met Uncertain significance Single submitter
- ALPG p.Thr282Asn Uncertain significance Single submitter
- ALPG p.Thr350Met Uncertain significance Single submitter
- ALPG p.Thr67Met Uncertain significance Single submitter
- ALPG p.Val104Ile Uncertain significance Single submitter
- ALPG p.Val151Met Uncertain significance Single submitter
- ALPG p.Val183Met Uncertain significance Single submitter
- ALPG p.Val373Ile Uncertain significance Single submitter
- ALPG p.Val373Leu Uncertain significance Single submitter
- ALPG p.Val380Ile Uncertain significance Single submitter
- ALPG p.Val96Met Uncertain significance Single submitter
All ALPG variants
Benign 9
- p.Arg498Pro Multiple submitters
- p.Gly230= Multiple submitters
- p.Leu8= Multiple submitters
- p.Pro228Arg Multiple submitters ⚠
- p.Pro94Ser Multiple submitters ⚠
- p.Ser150= Multiple submitters
- p.Tyr95Phe Multiple submitters ⚠
- p.Ala51= Single submitter
- p.Tyr179= Single submitter
Benign/Likely benign 1
- p.His172= Multiple submitters
Likely benign 14
- p.Gly500Asp Multiple submitters
- c.1300+10G>A Single submitter
- p.Ala178Thr Single submitter
- p.Ala36= Single submitter
- p.Arg223Gln Single submitter ⚠
- p.Arg264Gln Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Asp80Gly Single submitter
- p.His466= Single submitter
- p.Leu252= Single submitter
- p.Ser103Asn Single submitter
- p.Ser301Pro Single submitter
- p.Val193Met Single submitter
- p.Val96Leu Single submitter
Uncertain significance 102
- p.Ala135Thr Single submitter ⚠
- p.Ala180Thr Single submitter ⚠
- p.Ala206Thr Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala360Val Single submitter ⚠
- p.Ala406Thr Single submitter ⚠
- p.Ala42Thr Single submitter ⚠
- p.Ala48Thr Single submitter ⚠
- p.Ala492Val Single submitter ⚠
- p.Ala52Thr Single submitter ⚠
- p.Ala89Val Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg136Leu Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg154Trp Single submitter ⚠
- p.Arg169Trp Single submitter ⚠
- p.Arg185Cys Single submitter ⚠
- p.Arg198Gly Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg33Cys Single submitter ⚠
- p.Arg33His Single submitter ⚠
- p.Arg425Pro Single submitter ⚠
- p.Arg439Gln Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Asn184His Single submitter ⚠
- p.Asn268Lys Single submitter ⚠
- p.Asp233Glu Single submitter ⚠
- p.Asp278Asn Single submitter ⚠
- p.Asp376Asn Single submitter ⚠
- p.Asp422Glu Single submitter ⚠
- p.Cys120Ser Single submitter ⚠
- p.Cys120Trp Single submitter ⚠
- p.Cys493Arg Single submitter ⚠
- p.Gln2Leu Single submitter ⚠
- p.Gln441Leu Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu367Asp Single submitter ⚠
- p.Glu37Ala Single submitter ⚠
- p.Glu430Lys Single submitter ⚠
- p.Glu454Lys Single submitter ⚠
- p.Gly121Arg Single submitter ⚠
- p.Gly124Ser Single submitter ⚠
- p.Gly177Ser Single submitter ⚠
- p.Gly201Arg Single submitter ⚠
- p.Gly390Glu Single submitter ⚠
- p.Gly399Asp Single submitter ⚠
- p.Gly3Val Single submitter ⚠
- p.Gly423Ser Single submitter ⚠
- p.Gly470Ser Single submitter ⚠
- p.Gly527Glu Single submitter ⚠
- p.Gly62Glu Single submitter ⚠
- p.Gly62Val Single submitter ⚠
- p.Gly64Arg Single submitter ⚠
- p.His181Tyr Single submitter ⚠
- p.His466Tyr Single submitter ⚠
- p.Ile149Thr Single submitter ⚠
- p.Ile57Val Single submitter ⚠
- p.Leu495Val Single submitter ⚠
- p.Leu524Pro Single submitter ⚠
- p.Leu8Phe Single submitter ⚠
- p.Lys160Asn Single submitter ⚠
- p.Lys224Asn Single submitter ⚠
- p.Lys259Thr Single submitter ⚠
- p.Lys421Glu Single submitter ⚠
- p.Met308Thr Single submitter ⚠
- p.Phe394Leu Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro232Ser Single submitter ⚠
- p.Pro305Ser Single submitter ⚠
- p.Pro445Ser Single submitter ⚠
- p.Pro497Leu Single submitter ⚠
- p.Pro509Ala Single submitter ⚠
- p.Pro509Ser Single submitter ⚠
- p.Ser189Leu Single submitter ⚠
- p.Ser196Leu Single submitter ⚠
- p.Ser306Phe Single submitter ⚠
- p.Ser306Pro Single submitter ⚠
- p.Ser319Asn Single submitter ⚠
- p.Ser382Phe Single submitter ⚠
- p.Ser431Asn Single submitter ⚠
- p.Ser433Arg Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr142Met Single submitter ⚠
- p.Thr182Met Single submitter ⚠
- p.Thr207Met Single submitter ⚠
- p.Thr282Asn Single submitter ⚠
- p.Thr350Met Single submitter ⚠
- p.Thr374Asn Single submitter ⚠
- p.Thr50Arg Single submitter ⚠
- p.Thr67Met Single submitter ⚠
- p.Thr86Asn Single submitter ⚠
- p.Trp267Arg Single submitter ⚠
- p.Trp267Cys Single submitter ⚠
- p.Tyr412Asp Single submitter ⚠
- p.Val104Ile Single submitter ⚠
- p.Val151Met Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val373Ile Single submitter ⚠
- p.Val373Leu Single submitter ⚠
- p.Val380Ile Single submitter ⚠
- p.Val471Glu Single submitter ⚠
- p.Val96Met Single submitter ⚠