ALPP — 133 ClinVar variants
All ClinVar germline ALPP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 114 flagged for review →
9 Benign · 11 Likely benign · 113 Uncertain significance
Full ALPP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 114
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALPP p.Ala138Val Uncertain significance Single submitter
- ALPP p.Ala176Pro Uncertain significance Single submitter
- ALPP p.Ala176Thr Uncertain significance Single submitter
- ALPP p.Ala349Glu Uncertain significance Single submitter
- ALPP p.Ala502Pro Uncertain significance Single submitter
- ALPP p.Ala534Pro Uncertain significance Single submitter
- ALPP p.Arg188His Uncertain significance Single submitter
- ALPP p.Arg188Ser Uncertain significance Single submitter
- ALPP p.Arg249Lys Uncertain significance Single submitter
- ALPP p.Arg302Pro Uncertain significance Single submitter
- ALPP p.Arg348Gln Uncertain significance Single submitter
- ALPP p.Arg348Trp Uncertain significance Single submitter
- ALPP p.Arg428Gln Uncertain significance Single submitter
- ALPP p.Arg512Gln Uncertain significance Single submitter
- ALPP p.Asn324Lys Uncertain significance Single submitter
- ALPP p.Asp113Glu Uncertain significance Single submitter
- ALPP p.Asp195Glu Uncertain significance Single submitter
- ALPP p.Asp207Glu Uncertain significance Single submitter
- ALPP p.Asp32Glu Uncertain significance Single submitter
- ALPP p.Asp338Glu Uncertain significance Single submitter
- ALPP p.Asp430Asn Uncertain significance Single submitter
- ALPP p.Asp506Glu Uncertain significance Single submitter
- ALPP p.Cys143Arg Uncertain significance Single submitter
- ALPP p.Gln18His Uncertain significance Single submitter
- ALPP p.Glu530Lys Uncertain significance Single submitter
- ALPP p.Gly340Val Uncertain significance Single submitter
- ALPP p.Gly387Arg Uncertain significance Single submitter
- ALPP p.Gly388Asp Uncertain significance Single submitter
- ALPP p.Gly503Arg Uncertain significance Single submitter
- ALPP p.Gly63Val Uncertain significance Single submitter
- ALPP p.His342Asn Uncertain significance Single submitter
- ALPP p.Ile152Met Uncertain significance Single submitter
- ALPP p.Ile396Thr Uncertain significance Single submitter
- ALPP p.Leu13Pro Uncertain significance Single submitter
- ALPP p.Leu19Pro Uncertain significance Single submitter
- ALPP p.Leu498Arg Uncertain significance Single submitter
- ALPP p.Lys126Gln Uncertain significance Single submitter
- ALPP p.Lys159Thr Uncertain significance Single submitter
- ALPP p.Met229Ile Uncertain significance Single submitter
- ALPP p.Met276Val Uncertain significance Single submitter
- ALPP p.Met311Thr Uncertain significance Single submitter
- ALPP p.Pro87Thr Uncertain significance Single submitter
- ALPP p.Pro90Arg Uncertain significance Single submitter
- ALPP p.Ser438Arg Uncertain significance Single submitter
- ALPP p.Thr185Lys Uncertain significance Single submitter
- ALPP p.Thr210Met Uncertain significance Single submitter
- ALPP p.Thr314Arg Uncertain significance Single submitter
- ALPP p.Thr353Arg Uncertain significance Single submitter
- ALPP p.Tyr105His Uncertain significance Single submitter
- ALPP p.Tyr415Asp Uncertain significance Single submitter
- ALPP p.Val173Glu Uncertain significance Single submitter
Predictors split 63
The independent predictors disagree with each other — read with care.
- ALPP p.Ala176Gly Uncertain significance Single submitter
- ALPP p.Ala176Ser Uncertain significance Single submitter
- ALPP p.Ala183Thr Uncertain significance Single submitter
- ALPP p.Ala183Val Uncertain significance Single submitter
- ALPP p.Ala209Ser Uncertain significance Single submitter
- ALPP p.Ala266Ser Uncertain significance Single submitter
- ALPP p.Ala363Val Uncertain significance Single submitter
- ALPP p.Ala45Thr Uncertain significance Single submitter
- ALPP p.Ala523Ser Uncertain significance Single submitter
- ALPP p.Ala55Thr Uncertain significance Single submitter
- ALPP p.Arg139Cys Uncertain significance Single submitter
- ALPP p.Arg139His Uncertain significance Single submitter
- ALPP p.Arg201His Uncertain significance Single submitter
- ALPP p.Arg267Trp Uncertain significance Single submitter
- ALPP p.Arg272Cys Uncertain significance Single submitter
- ALPP p.Arg272Gly Uncertain significance Single submitter
- ALPP p.Arg272Ser Uncertain significance Single submitter
- ALPP p.Arg326Cys Uncertain significance Single submitter
- ALPP p.Arg326His Uncertain significance Single submitter
- ALPP p.Arg36His Uncertain significance Single submitter
- ALPP p.Arg405Gly Uncertain significance Single submitter
- ALPP p.Arg95Cys Uncertain significance Single submitter
- ALPP p.Asn128Ile Uncertain significance Single submitter
- ALPP p.Gln49His Uncertain significance Single submitter
- ALPP p.Glu369Gln Uncertain significance Single submitter
- ALPP p.Gly148Arg Uncertain significance Single submitter
- ALPP p.Gly180Ser Uncertain significance Single submitter
- ALPP p.Gly252Arg Uncertain significance Single submitter
- ALPP p.Gly524Arg Uncertain significance Single submitter
- ALPP p.His184Asn Uncertain significance Single submitter
- ALPP p.Ile152Asn Uncertain significance Single submitter
- ALPP p.Ile208Thr Uncertain significance Single submitter
- ALPP p.Ile218Phe Uncertain significance Single submitter
- ALPP p.Ile300Phe Uncertain significance Single submitter
- ALPP p.Ile337Met Uncertain significance Single submitter
- ALPP p.Ile480Thr Uncertain significance Single submitter
- ALPP p.Leu122Val Uncertain significance Single submitter
- ALPP p.Leu366Arg Uncertain significance Single submitter
- ALPP p.Leu375Phe Uncertain significance Single submitter
- ALPP p.Leu522Pro Uncertain significance Single submitter
- ALPP p.Leu526Val Uncertain significance Single submitter
- ALPP p.Leu91Val Uncertain significance Single submitter
- ALPP p.Leu9Val Uncertain significance Single submitter
- ALPP p.Met229Val Uncertain significance Single submitter
- ALPP p.Met355Thr Uncertain significance Single submitter
- ALPP p.Pro197Thr Uncertain significance Single submitter
- ALPP p.Pro235Ser Uncertain significance Single submitter
- ALPP p.Pro240Ala Uncertain significance Single submitter
- ALPP p.Pro25Leu Benign Single submitter
- ALPP p.Pro293Thr Uncertain significance Single submitter
- ALPP p.Pro429Leu Uncertain significance Single submitter
- ALPP p.Pro448Ser Uncertain significance Single submitter
- ALPP p.Pro500Leu Uncertain significance Single submitter
- ALPP p.Pro520Arg Uncertain significance Single submitter
- ALPP p.Ser199Phe Uncertain significance Single submitter
- ALPP p.Thr181Ile Uncertain significance Single submitter
- ALPP p.Thr353Met Uncertain significance Single submitter
- ALPP p.Thr411Met Uncertain significance Single submitter
- ALPP p.Thr70Met Uncertain significance Single submitter
- ALPP p.Tyr389Asp Uncertain significance Single submitter
- ALPP p.Val256Met Uncertain significance Single submitter
- ALPP p.Val376Leu Uncertain significance Single submitter
- ALPP p.Val431Ala Uncertain significance Single submitter
All ALPP variants
Benign 9
- p.Ala176= Multiple submitters
- p.Arg231Pro Multiple submitters
- p.Arg36= Multiple submitters
- p.Glu37Gln Multiple submitters
- p.Phe331= Multiple submitters
- p.Ser244Gly Multiple submitters
- p.Asp219= Single submitter
- p.Pro25Leu Single submitter ⚠
- p.Pro25= No assertion criteria ALKALINE PHOSPHATASE, PLACENTAL, ALLELE-1 POLYMORPHISM
Likely benign 11
- c.865+8C>T Multiple submitters
- p.Gly233= Multiple submitters
- p.Gly63= Multiple submitters
- p.Ser192Trp Multiple submitters
- p.Tyr268= Multiple submitters
- c.77-9C>T Single submitter
- p.Ala455Gly Single submitter
- p.Asp32Ala Single submitter
- p.Glu370Lys Single submitter
- p.Glu530Gly Single submitter
- p.Lys253Arg Single submitter
Uncertain significance 113
- p.Ala138Val Single submitter ⚠
- p.Ala176Gly Single submitter ⚠
- p.Ala176Pro Single submitter ⚠
- p.Ala176Ser Single submitter ⚠
- p.Ala176Thr Single submitter ⚠
- p.Ala183Thr Single submitter ⚠
- p.Ala183Val Single submitter ⚠
- p.Ala209Ser Single submitter ⚠
- p.Ala266Ser Single submitter ⚠
- p.Ala349Glu Single submitter ⚠
- p.Ala363Val Single submitter ⚠
- p.Ala45Thr Single submitter ⚠
- p.Ala502Pro Single submitter ⚠
- p.Ala523Ser Single submitter ⚠
- p.Ala534Pro Single submitter ⚠
- p.Ala55Thr Single submitter ⚠
- p.Arg139Cys Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg188Ser Single submitter ⚠
- p.Arg201His Single submitter ⚠
- p.Arg249Lys Single submitter ⚠
- p.Arg267Trp Single submitter ⚠
- p.Arg272Cys Single submitter ⚠
- p.Arg272Gly Single submitter ⚠
- p.Arg272Ser Single submitter ⚠
- p.Arg302Pro Single submitter ⚠
- p.Arg326Cys Single submitter ⚠
- p.Arg326His Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg348Trp Single submitter ⚠
- p.Arg36His Single submitter ⚠
- p.Arg405Gly Single submitter ⚠
- p.Arg428Gln Single submitter ⚠
- p.Arg512Gln Single submitter ⚠
- p.Arg95Cys Single submitter ⚠
- p.Asn128Ile Single submitter ⚠
- p.Asn324Lys Single submitter ⚠
- p.Asp113Glu Single submitter ⚠
- p.Asp195Glu Single submitter ⚠
- p.Asp207Glu Single submitter ⚠
- p.Asp32Glu Single submitter ⚠
- p.Asp338Glu Single submitter ⚠
- p.Asp430Asn Single submitter ⚠
- p.Asp506Glu Single submitter ⚠
- p.Cys143Arg Single submitter ⚠
- p.Gln18His Single submitter ⚠
- p.Gln49His Single submitter ⚠
- p.Glu369Gln Single submitter ⚠
- p.Glu530Lys Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.Gly180Ser Single submitter ⚠
- p.Gly252Arg Single submitter ⚠
- p.Gly340Val Single submitter ⚠
- p.Gly387Arg Single submitter ⚠
- p.Gly388Asp Single submitter ⚠
- p.Gly503Arg Single submitter ⚠
- p.Gly524Arg Single submitter ⚠
- p.Gly63Val Single submitter ⚠
- p.His184Asn Single submitter ⚠
- p.His342Asn Single submitter ⚠
- p.Ile152Asn Single submitter ⚠
- p.Ile152Met Single submitter ⚠
- p.Ile208Thr Single submitter ⚠
- p.Ile218Phe Single submitter ⚠
- p.Ile300Phe Single submitter ⚠
- p.Ile337Met Single submitter ⚠
- p.Ile396Thr Single submitter ⚠
- p.Ile480Thr Single submitter ⚠
- p.Leu122Val Single submitter ⚠
- p.Leu13Pro Single submitter ⚠
- p.Leu19Pro Single submitter ⚠
- p.Leu366Arg Single submitter ⚠
- p.Leu375Phe Single submitter ⚠
- p.Leu498Arg Single submitter ⚠
- p.Leu522Pro Single submitter ⚠
- p.Leu526Val Single submitter ⚠
- p.Leu91Val Single submitter ⚠
- p.Leu9Val Single submitter ⚠
- p.Lys126Gln Single submitter ⚠
- p.Lys159Thr Single submitter ⚠
- p.Met229Ile Single submitter ⚠
- p.Met229Val Single submitter ⚠
- p.Met276Val Single submitter ⚠
- p.Met311Thr Single submitter ⚠
- p.Met355Thr Single submitter ⚠
- p.Pro197Thr Single submitter ⚠
- p.Pro235Ser Single submitter ⚠
- p.Pro240Ala Single submitter ⚠
- p.Pro293Thr Single submitter ⚠
- p.Pro429Leu Single submitter ⚠
- p.Pro448Ser Single submitter ⚠
- p.Pro500Leu Single submitter ⚠
- p.Pro520Arg Single submitter ⚠
- p.Pro87Thr Single submitter ⚠
- p.Pro90Arg Single submitter ⚠
- p.Ser199Phe Single submitter ⚠
- p.Ser438Arg Single submitter ⚠
- p.Thr181Ile Single submitter ⚠
- p.Thr185Lys Single submitter ⚠
- p.Thr210Met Single submitter ⚠
- p.Thr314Arg Single submitter ⚠
- p.Thr353Arg Single submitter ⚠
- p.Thr353Met Single submitter ⚠
- p.Thr411Met Single submitter ⚠
- p.Thr70Met Single submitter ⚠
- p.Tyr105His Single submitter ⚠
- p.Tyr389Asp Single submitter ⚠
- p.Tyr415Asp Single submitter ⚠
- p.Val173Glu Single submitter ⚠
- p.Val256Met Single submitter ⚠
- p.Val376Leu Single submitter ⚠
- p.Val431Ala Single submitter ⚠