Sugi Variant

Sugi Variant/ALX3

ALX3 — 95 ClinVar variants

All ClinVar germline ALX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →

9 Pathogenic · 1 Likely pathogenic · 1 Conflicting · 10 Benign · 2 Benign/Likely benign · 10 Likely benign · 62 Uncertain significance

Full ALX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 62

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 46

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 16

The independent predictors disagree with each other — read with care.

All ALX3 variants

Pathogenic 9

Likely pathogenic 1

Conflicting classifications of pathogenicity 1

Benign 10

Benign/Likely benign 2

Likely benign 10

Uncertain significance 62