AMER2 — 112 ClinVar variants
All ClinVar germline AMER2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
4 Likely benign · 108 Uncertain significance
Full AMER2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AMER2 p.Ala158Gly Uncertain significance Single submitter
- AMER2 p.Ala158Pro Uncertain significance Single submitter
- AMER2 p.Ala214Pro Uncertain significance Single submitter
- AMER2 p.Ala219Val Uncertain significance Single submitter
- AMER2 p.Ala245Ser Uncertain significance Single submitter
- AMER2 p.Ala260Glu Uncertain significance Single submitter
- AMER2 p.Ala319Pro Uncertain significance Single submitter
- AMER2 p.Ala324Thr Uncertain significance Single submitter
- AMER2 p.Ala345Thr Uncertain significance Single submitter
- AMER2 p.Ala392Ser Uncertain significance Single submitter
- AMER2 p.Ala457Val Uncertain significance Single submitter
- AMER2 p.Ala463Glu Uncertain significance Single submitter
- AMER2 p.Ala485Thr Uncertain significance Single submitter
- AMER2 p.Ala50Pro Uncertain significance Single submitter
- AMER2 p.Ala543Val Uncertain significance Single submitter
- AMER2 p.Ala661Val Uncertain significance Single submitter
- AMER2 p.Ala66Thr Uncertain significance Single submitter
- AMER2 p.Arg172Leu Uncertain significance Single submitter
- AMER2 p.Arg209Pro Uncertain significance Single submitter
- AMER2 p.Arg218Gly Uncertain significance Single submitter
- AMER2 p.Arg27Gly Uncertain significance Single submitter
- AMER2 p.Arg282Gly Uncertain significance Single submitter
- AMER2 p.Arg491Thr Uncertain significance Single submitter
- AMER2 p.Arg492Ser Uncertain significance Single submitter
- AMER2 p.Arg583Gln Uncertain significance Single submitter
- AMER2 p.Asn175Ser Uncertain significance Single submitter
- AMER2 p.Asn575Ser Uncertain significance Single submitter
- AMER2 p.Asn617Ser Uncertain significance Single submitter
- AMER2 p.Asp207Glu Uncertain significance Single submitter
- AMER2 p.Asp292Gly Uncertain significance Single submitter
- AMER2 p.Asp368Tyr Uncertain significance Single submitter
- AMER2 p.Gln513His Uncertain significance Single submitter
- AMER2 p.Glu298Asp Uncertain significance Single submitter
- AMER2 p.Glu336Gln Uncertain significance Single submitter
- AMER2 p.Glu430Asp Uncertain significance Single submitter
- AMER2 p.Glu447Lys Uncertain significance Single submitter
- AMER2 p.Glu480Val Uncertain significance Single submitter
- AMER2 p.Gly149Glu Uncertain significance Single submitter
- AMER2 p.Gly17Ser Uncertain significance Single submitter
- AMER2 p.Gly187Arg Uncertain significance Single submitter
- AMER2 p.Gly18Ala Uncertain significance Single submitter
- AMER2 p.Gly221Ala Uncertain significance Single submitter
- AMER2 p.Gly265Ala Uncertain significance Single submitter
- AMER2 p.Gly311Arg Uncertain significance Single submitter
- AMER2 p.Gly35Ala Uncertain significance Single submitter
- AMER2 p.Gly37Arg Uncertain significance Single submitter
- AMER2 p.Gly77Ser Uncertain significance Single submitter
- AMER2 p.Gly99Arg Uncertain significance Single submitter
- AMER2 p.His46Tyr Uncertain significance Single submitter
- AMER2 p.Ile545Thr Uncertain significance Single submitter
- AMER2 p.Leu378Ile Uncertain significance Single submitter
- AMER2 p.Leu378Val Uncertain significance Single submitter
- AMER2 p.Leu558Arg Uncertain significance Single submitter
- AMER2 p.Leu645Val Uncertain significance Single submitter
- AMER2 p.Lys410Glu Uncertain significance Single submitter
- AMER2 p.Lys459Glu Uncertain significance Single submitter
- AMER2 p.Lys467Arg Uncertain significance Single submitter
- AMER2 p.Pro137Ala Uncertain significance Single submitter
- AMER2 p.Pro137Thr Uncertain significance Single submitter
- AMER2 p.Pro251Ser Uncertain significance Single submitter
- AMER2 p.Pro263Ala Uncertain significance Single submitter
- AMER2 p.Pro270Ser Uncertain significance Single submitter
- AMER2 p.Pro357Leu Uncertain significance Single submitter
- AMER2 p.Pro54Ser Uncertain significance Single submitter
- AMER2 p.Pro589Ser Uncertain significance Single submitter
- AMER2 p.Ser117Asn Uncertain significance Single submitter
- AMER2 p.Ser117Thr Uncertain significance Single submitter
- AMER2 p.Ser184Arg Uncertain significance Single submitter
- AMER2 p.Ser184Gly Uncertain significance Single submitter
- AMER2 p.Ser486Pro Uncertain significance Single submitter
- AMER2 p.Ser6Gly Uncertain significance Single submitter
- AMER2 p.Thr315Lys Uncertain significance Single submitter
- AMER2 p.Thr568Ile Uncertain significance Single submitter
- AMER2 p.Thr591Ile Uncertain significance Single submitter
- AMER2 p.Val86Ala Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- AMER2 p.Ala212Val Uncertain significance Single submitter
- AMER2 p.Arg495Trp Uncertain significance Single submitter
- AMER2 p.Arg583Trp Uncertain significance Single submitter
- AMER2 p.Arg647Ser Uncertain significance Single submitter
- AMER2 p.Asp429Asn Uncertain significance Single submitter
- AMER2 p.Asp553Asn Uncertain significance Single submitter
- AMER2 p.Glu121Lys Uncertain significance Single submitter
- AMER2 p.Glu15Lys Uncertain significance Single submitter
- AMER2 p.Gly10Arg Uncertain significance Single submitter
- AMER2 p.Gly126Glu Uncertain significance Single submitter
- AMER2 p.Gly130Ser Uncertain significance Single submitter
- AMER2 p.Gly132Asp Uncertain significance Single submitter
- AMER2 p.Gly134Arg Uncertain significance Single submitter
- AMER2 p.Gly196Arg Uncertain significance Single submitter
- AMER2 p.Gly200Asp Uncertain significance Single submitter
- AMER2 p.Gly265Trp Uncertain significance Single submitter
- AMER2 p.Gly265Val Uncertain significance Single submitter
- AMER2 p.Gly311Trp Uncertain significance Single submitter
- AMER2 p.Gly33Arg Uncertain significance Single submitter
- AMER2 p.His204Tyr Uncertain significance Single submitter
- AMER2 p.Ile362Val Uncertain significance Single submitter
- AMER2 p.Leu234Gln Uncertain significance Single submitter
- AMER2 p.Leu671Met Uncertain significance Single submitter
- AMER2 p.Leu70Val Uncertain significance Single submitter
- AMER2 p.Met425Ile Uncertain significance Single submitter
- AMER2 p.Pro220Leu Uncertain significance Single submitter
- AMER2 p.Pro310Leu Uncertain significance Single submitter
- AMER2 p.Ser549Gly Uncertain significance Single submitter
- AMER2 p.Thr38Asn Uncertain significance Single submitter
- AMER2 p.Thr434Ile Uncertain significance Single submitter
- AMER2 p.Thr529Met Uncertain significance Single submitter
- AMER2 p.Trp203Cys Uncertain significance Single submitter
- AMER2 p.Val468Met Uncertain significance Single submitter
All AMER2 variants
Likely benign 4
- p.Ala264Gly Single submitter
- p.Glu448Asp Single submitter
- p.Pro272Ser Single submitter
- p.Ser539Gly Single submitter
Uncertain significance 108
- p.Ala158Gly Single submitter ⚠
- p.Ala158Pro Single submitter ⚠
- p.Ala212Val Single submitter ⚠
- p.Ala214Pro Single submitter ⚠
- p.Ala219Val Single submitter ⚠
- p.Ala245Ser Single submitter ⚠
- p.Ala260Glu Single submitter ⚠
- p.Ala319Pro Single submitter ⚠
- p.Ala324Thr Single submitter ⚠
- p.Ala345Thr Single submitter ⚠
- p.Ala392Ser Single submitter ⚠
- p.Ala457Val Single submitter ⚠
- p.Ala463Glu Single submitter ⚠
- p.Ala485Thr Single submitter ⚠
- p.Ala50Pro Single submitter ⚠
- p.Ala543Val Single submitter ⚠
- p.Ala661Val Single submitter ⚠
- p.Ala66Thr Single submitter ⚠
- p.Arg172Leu Single submitter ⚠
- p.Arg209Pro Single submitter ⚠
- p.Arg218Gly Single submitter ⚠
- p.Arg27Gly Single submitter ⚠
- p.Arg282Gly Single submitter ⚠
- p.Arg491Thr Single submitter ⚠
- p.Arg492Ser Single submitter ⚠
- p.Arg495Trp Single submitter ⚠
- p.Arg583Gln Single submitter ⚠
- p.Arg583Trp Single submitter ⚠
- p.Arg647Ser Single submitter ⚠
- p.Asn175Ser Single submitter ⚠
- p.Asn575Ser Single submitter ⚠
- p.Asn617Ser Single submitter ⚠
- p.Asp207Glu Single submitter ⚠
- p.Asp292Gly Single submitter ⚠
- p.Asp368Tyr Single submitter ⚠
- p.Asp429Asn Single submitter ⚠
- p.Asp553Asn Single submitter ⚠
- p.Gln513His Single submitter ⚠
- p.Glu121Lys Single submitter ⚠
- p.Glu15Lys Single submitter ⚠
- p.Glu298Asp Single submitter ⚠
- p.Glu336Gln Single submitter ⚠
- p.Glu430Asp Single submitter ⚠
- p.Glu447Lys Single submitter ⚠
- p.Glu480Val Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly126Glu Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly132Asp Single submitter ⚠
- p.Gly134Arg Single submitter ⚠
- p.Gly149Glu Single submitter ⚠
- p.Gly17Ser Single submitter ⚠
- p.Gly187Arg Single submitter ⚠
- p.Gly18Ala Single submitter ⚠
- p.Gly196Arg Single submitter ⚠
- p.Gly200Asp Single submitter ⚠
- p.Gly221Ala Single submitter ⚠
- p.Gly265Ala Single submitter ⚠
- p.Gly265Trp Single submitter ⚠
- p.Gly265Val Single submitter ⚠
- p.Gly311Arg Single submitter ⚠
- p.Gly311Trp Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly35Ala Single submitter ⚠
- p.Gly37Arg Single submitter ⚠
- p.Gly77Ser Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.His204Tyr Single submitter ⚠
- p.His46Tyr Single submitter ⚠
- p.Ile362Val Single submitter ⚠
- p.Ile545Thr Single submitter ⚠
- p.Leu234Gln Single submitter ⚠
- p.Leu378Ile Single submitter ⚠
- p.Leu378Val Single submitter ⚠
- p.Leu558Arg Single submitter ⚠
- p.Leu645Val Single submitter ⚠
- p.Leu671Met Single submitter ⚠
- p.Leu70Val Single submitter ⚠
- p.Lys410Glu Single submitter ⚠
- p.Lys459Glu Single submitter ⚠
- p.Lys467Arg Single submitter ⚠
- p.Met425Ile Single submitter ⚠
- p.Pro137Ala Single submitter ⚠
- p.Pro137Thr Single submitter ⚠
- p.Pro220Leu Single submitter ⚠
- p.Pro251Ser Single submitter ⚠
- p.Pro263Ala Single submitter ⚠
- p.Pro270Ser Single submitter ⚠
- p.Pro310Leu Single submitter ⚠
- p.Pro357Leu Single submitter ⚠
- p.Pro54Ser Single submitter ⚠
- p.Pro589Ser Single submitter ⚠
- p.Ser117Asn Single submitter ⚠
- p.Ser117Thr Single submitter ⚠
- p.Ser184Arg Single submitter ⚠
- p.Ser184Gly Single submitter ⚠
- p.Ser486Pro Single submitter ⚠
- p.Ser549Gly Single submitter ⚠
- p.Ser6Gly Single submitter ⚠
- p.Thr315Lys Single submitter ⚠
- p.Thr38Asn Single submitter ⚠
- p.Thr434Ile Single submitter ⚠
- p.Thr529Met Single submitter ⚠
- p.Thr568Ile Single submitter ⚠
- p.Thr591Ile Single submitter ⚠
- p.Trp203Cys Single submitter ⚠
- p.Val468Met Single submitter ⚠
- p.Val86Ala Single submitter ⚠