AMIGO2 — 66 ClinVar variants
All ClinVar germline AMIGO2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
1 Benign · 2 Likely benign · 63 Uncertain significance
Full AMIGO2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AMIGO2 p.Ala300Thr Uncertain significance Single submitter
- AMIGO2 p.Ala520Val Uncertain significance Single submitter
- AMIGO2 p.Ala93Thr Uncertain significance Single submitter
- AMIGO2 p.Arg261Ser Uncertain significance Single submitter
- AMIGO2 p.Arg270Ser Uncertain significance Single submitter
- AMIGO2 p.Arg354Ser Uncertain significance Single submitter
- AMIGO2 p.Arg370His Uncertain significance Single submitter
- AMIGO2 p.Arg370Ser Uncertain significance Single submitter
- AMIGO2 p.Arg430Thr Uncertain significance Single submitter
- AMIGO2 p.Arg458Pro Uncertain significance Single submitter
- AMIGO2 p.Arg465Lys Uncertain significance Single submitter
- AMIGO2 p.Arg4Gly Uncertain significance Single submitter
- AMIGO2 p.Arg4His Uncertain significance Single submitter
- AMIGO2 p.Asn127Lys Uncertain significance Single submitter
- AMIGO2 p.Asn328Asp Uncertain significance Single submitter
- AMIGO2 p.Asn328Ser Uncertain significance Single submitter
- AMIGO2 p.Asn510Ser Uncertain significance Single submitter
- AMIGO2 p.Asp277Asn Uncertain significance Single submitter
- AMIGO2 p.Asp452Gly Uncertain significance Single submitter
- AMIGO2 p.Cys363Tyr Uncertain significance Single submitter
- AMIGO2 p.Gln179Arg Uncertain significance Single submitter
- AMIGO2 p.Gln437Lys Uncertain significance Single submitter
- AMIGO2 p.Gln479Leu Uncertain significance Single submitter
- AMIGO2 p.Glu22Gln Uncertain significance Single submitter
- AMIGO2 p.Glu299Asp Uncertain significance Single submitter
- AMIGO2 p.Glu489Lys Uncertain significance Single submitter
- AMIGO2 p.Gly461Ser Uncertain significance Single submitter
- AMIGO2 p.Gly64Val Uncertain significance Single submitter
- AMIGO2 p.Ile51Leu Uncertain significance Single submitter
- AMIGO2 p.Lys498Arg Uncertain significance Single submitter
- AMIGO2 p.Lys503Glu Uncertain significance Single submitter
- AMIGO2 p.Met337Leu Uncertain significance Single submitter
- AMIGO2 p.Met366Thr Uncertain significance Single submitter
- AMIGO2 p.Met434Thr Uncertain significance Single submitter
- AMIGO2 p.Pro18Leu Uncertain significance Single submitter
- AMIGO2 p.Pro35Ala Uncertain significance Single submitter
- AMIGO2 p.Pro423Leu Uncertain significance Single submitter
- AMIGO2 p.Pro423Ser Uncertain significance Single submitter
- AMIGO2 p.Ser235Ala Uncertain significance Single submitter
- AMIGO2 p.Ser290Tyr Uncertain significance Single submitter
- AMIGO2 p.Ser91Leu Uncertain significance Single submitter
- AMIGO2 p.Thr314Ile Uncertain significance Single submitter
- AMIGO2 p.Val387Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- AMIGO2 p.Arg203Gly Uncertain significance Single submitter
- AMIGO2 p.Arg245Pro Uncertain significance Single submitter
- AMIGO2 p.Arg246Ser Uncertain significance Single submitter
- AMIGO2 p.Arg270Leu Uncertain significance Single submitter
- AMIGO2 p.Arg354His Uncertain significance Single submitter
- AMIGO2 p.Gly111Ser Uncertain significance Single submitter
- AMIGO2 p.Ile496Met Uncertain significance Single submitter
- AMIGO2 p.Leu12Phe Uncertain significance Single submitter
- AMIGO2 p.Leu214Phe Uncertain significance Single submitter
- AMIGO2 p.Leu220Val Uncertain significance Single submitter
- AMIGO2 p.Leu403Phe Uncertain significance Single submitter
- AMIGO2 p.Lys141Met Uncertain significance Single submitter
- AMIGO2 p.Phe248Leu Uncertain significance Single submitter
- AMIGO2 p.Phe340Leu Uncertain significance Single submitter
- AMIGO2 p.Ser446Asn Uncertain significance Single submitter
- AMIGO2 p.Ser454Tyr Uncertain significance Single submitter
- AMIGO2 p.Ser506Pro Uncertain significance Single submitter
- AMIGO2 p.Thr131Met Uncertain significance Single submitter
- AMIGO2 p.Thr55Ala Uncertain significance Single submitter
- AMIGO2 p.Trp87Cys Uncertain significance Single submitter
All AMIGO2 variants
Benign 1
- p.Glu494= Multiple submitters
Likely benign 2
- p.Ser388Asn Single submitter
- p.Val324Met Single submitter
Uncertain significance 63
- p.Ala300Thr Single submitter ⚠
- p.Ala520Val Single submitter ⚠
- p.Ala93Thr Single submitter ⚠
- p.Arg203Gly Single submitter ⚠
- p.Arg245Pro Single submitter ⚠
- p.Arg246Ser Single submitter ⚠
- p.Arg261Ser Single submitter ⚠
- p.Arg270Leu Single submitter ⚠
- p.Arg270Ser Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg354Ser Single submitter ⚠
- p.Arg370His Single submitter ⚠
- p.Arg370Ser Single submitter ⚠
- p.Arg430Thr Single submitter ⚠
- p.Arg458Pro Single submitter ⚠
- p.Arg465Lys Single submitter ⚠
- p.Arg4Gly Single submitter ⚠
- p.Arg4His Single submitter ⚠
- p.Asn127Lys Single submitter ⚠
- p.Asn328Asp Single submitter ⚠
- p.Asn328Ser Single submitter ⚠
- p.Asn510Ser Single submitter ⚠
- p.Asp277Asn Single submitter ⚠
- p.Asp452Gly Single submitter ⚠
- p.Cys363Tyr Single submitter ⚠
- p.Gln179Arg Single submitter ⚠
- p.Gln437Lys Single submitter ⚠
- p.Gln479Leu Single submitter ⚠
- p.Glu22Gln Single submitter ⚠
- p.Glu299Asp Single submitter ⚠
- p.Glu489Lys Single submitter ⚠
- p.Gly111Ser Single submitter ⚠
- p.Gly461Ser Single submitter ⚠
- p.Gly64Val Single submitter ⚠
- p.Ile496Met Single submitter ⚠
- p.Ile51Leu Single submitter ⚠
- p.Leu12Phe Single submitter ⚠
- p.Leu214Phe Single submitter ⚠
- p.Leu220Val Single submitter ⚠
- p.Leu403Phe Single submitter ⚠
- p.Lys141Met Single submitter ⚠
- p.Lys498Arg Single submitter ⚠
- p.Lys503Glu Single submitter ⚠
- p.Met337Leu Single submitter ⚠
- p.Met366Thr Single submitter ⚠
- p.Met434Thr Single submitter ⚠
- p.Phe248Leu Single submitter ⚠
- p.Phe340Leu Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro35Ala Single submitter ⚠
- p.Pro423Leu Single submitter ⚠
- p.Pro423Ser Single submitter ⚠
- p.Ser235Ala Single submitter ⚠
- p.Ser290Tyr Single submitter ⚠
- p.Ser446Asn Single submitter ⚠
- p.Ser454Tyr Single submitter ⚠
- p.Ser506Pro Single submitter ⚠
- p.Ser91Leu Single submitter ⚠
- p.Thr131Met Single submitter ⚠
- p.Thr314Ile Single submitter ⚠
- p.Thr55Ala Single submitter ⚠
- p.Trp87Cys Single submitter ⚠
- p.Val387Ile Single submitter ⚠