AMY1C — 9 ClinVar variants
All ClinVar germline AMY1C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
9 Uncertain significance
Full AMY1C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All AMY1C variants
Uncertain significance 9
- p.Ala333Thr Single submitter ⚠
- p.Arg352Gln Single submitter ⚠
- p.Arg358Cys Single submitter ⚠
- p.Glu364Ala Single submitter ⚠
- p.Gly296Val Single submitter ⚠
- p.Gly298Ser Single submitter ⚠
- p.Gly319Glu Single submitter ⚠
- p.Ile10Thr Single submitter ⚠
- p.Met302Thr Single submitter ⚠