ANAPC13 — 10 ClinVar variants
All ClinVar germline ANAPC13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
10 Uncertain significance
Full ANAPC13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANAPC13 p.Ala18Val Uncertain significance Single submitter
- ANAPC13 p.Ala30Thr Uncertain significance Single submitter
- ANAPC13 p.Asn68Ile Uncertain significance Single submitter
- ANAPC13 p.Asn68Thr Uncertain significance Single submitter
- ANAPC13 p.Leu24Arg Uncertain significance Single submitter
- ANAPC13 p.Thr47Ile Uncertain significance Single submitter
- ANAPC13 p.Val50Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ANAPC13 variants
Uncertain significance 10
- p.Ala18Val Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Asn68Ile Single submitter ⚠
- p.Asn68Thr Single submitter ⚠
- p.Gly9Arg Single submitter ⚠
- p.Ile15Phe Single submitter ⚠
- p.Leu24Arg Single submitter ⚠
- p.Leu24Val Single submitter ⚠
- p.Thr47Ile Single submitter ⚠
- p.Val50Ala Single submitter ⚠